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Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, pigmentation, proliferative and normal-like), which are predictive of survival outcome as well as informative of biology. Herein, we employed a population-based metastatic melan

Although the frequency of extra-pair paternity (EPP) has been described for many species, the relative importance of the various contemporary and historical factors explaining EPP variation is still the subject of debate. In this study, we found 11 polymorphic microsatellite loci in the Savi's Warbler (Locustella luscinioides), and used eight loci to analyze the paternity of 392 nestlings belongin

Binding of a targeting agent in tumor tissue is influenced by many factors such as molecular weight, charge and affinity of the targeting agent and vascularization of the tumor. In this study, we analyzed tumor cell binding of three HER2-specific and radiolabeled Affibody molecules with different affinities. The Affibody molecules had affinities in the range of 0.12-3.8 nM. Cellular binding was an

Candelaria pacifica is formally described. It is currently known from North and South America and Europe. The species is characterized by a small, lobate thallus with soredia formed on the lobe tips and along the margins. It has been confused with C. concolor in Europe and North America, but differs in having 8-spored asci and in lacking a lower cortex. Candelaria vulgaris, the type species of the

Fractions rich in indigestible carbohydrates, such as fructan and arabinoxylan, are obtained as by-products when ethanol, starch, and gluten are produced from wheat flour. Today, these fractions are used as animal feed. However, these components may have positive physiological effects in humans. In this study, the content of indigestible carbohydrates in distillers' grains and process streams from

In this work process water from a thermomechanical pulp mill was divided into five fractions by filtration and membrane filtration. Suspended matter was mainly isolated in the retentate from the drum filter, extractives in the microfiltration retentate, hemicelluloses in the ultrafiltration retentate and lignin in the nanofiltration retentate. The final water fraction was of fresh water quality. F

An absolute measure of the fat content in various organs is an important part of diagnostics in obesity and diabetes. Fat quantification using MR-imaging is a non-invasive technique which provides both quantitative and spatial information on fat accumulation. However, for absolute quantification, it is necessary to address the various sources of contrast in MR-imaging. This paper summarizes basic

Here, we show that the consequences of deficient micronutrient (beta-carotene) intake during larval stages of Manduca sexta are carried across metamorphosis, affecting adult behaviour. Our manipulation of larval diet allowed us to examine how developmental plasticity impacts the interplay between visual and olfactory inputs on adult foraging behaviour. Larvae of M. sexta were reared on natural (Ni

The properties of the amyloid-beta peptide that lead to aggregation associated with Alzheimer's disease are not fully understood. This study aims at identifying conformational differences among four variants of full-length Abeta42 that are known to display very different aggregation properties. By extensive all-atom Monte Carlo simulations, we find that a variety of beta-sheet structures with dist

Drought is a recurrent natural hazard that is expected to increase in the future due to anthropogenic climate change. The Middle East region witnessed a drought period between 2007 and 2009 that has been reported to have severe consequences for the population, especially in Syria and Iraq. This study seeks to assess the spatial and temporal characteristics of the drought in the Duhok Governorate i

Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca2+-dependent insulin exocytosis with respect to pool depletion and Ca2+-current inactivation. We studied exocytosis, measured as increase in membrane capacitance (ΔCm), as a function of calcium entry (Q) in insulin secreting INS-1 832/13 cells using patch cla

The focus of this paper is on how organizational change within medical research evolves and is influenced by different types of institutions at different geographical levels, as well as what characteristics of the key individuals are important in enacting institutional opportunities and overcoming hindrances. The paper reveals the complexity of institutions influencing change processes. First, the

We studied the commencement and finishing of the growing season using different air temperature indices, the surface albedo, the chlorophyll fluorescence (Fv/Fm) and the carbon dioxide (CO2) tropospheric concentration, together with eddy covariance measurements of CO2 flux. We used CO2 flux data from four boreal coniferous forest sites covering a wide latitudinal range, and CO2 concentration measu

Development of InN films for devices is hindered due to metallic In clusters, formed readily during growth, and unintentional n-type conductivity of the nominally undoped films, including surface electron-accumulation layers via the Fermi level pinning into the conduction band. Plasma nitridation eliminates even large In clusters from the surface by changing them to two-dimensional InN [Yamaguchi

Popular Abstract in Swedish Alla människor ska kunna vara delaktiga i samhället och mobilitet är viktigt för att kunna förflytta sig i bostaden och i samhället i stort. Mobilitet gör det möjligt att vara delaktig i olika aktiviteter som till exempel sociala aktiviteter och fritidsaktiviteter. Den åldrande befolkningen ökar och eftersom förflyttningssvårigheter ökar med stigande ålder, ökar även anThis thesis elucidates the use of powered mobility devices in a Swedish context. The overall aim was to increase and deepen the knowledge on powered mobility device use in relation to participation and accessibility in different environments and among different user groups, with a specific focus on independence and autonomy. An additional aim was to contribute to the knowledge base regarding the o

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Popular Abstract in Swedish I denna avhandling undersöker vi vilka anpassningar som behöver göras i designen av matematikkurser när de överförs från en kulturell miljö till en annan. Vi fokuserar på en kurs i beräkningsmatematik som undervisas på Lunds Universitet i Sverige och som vi under studien överförde till Sorans Universitet i Kurdistan/Irak. Projektet har två delar. Den första diskuterar hThis thesis aims to investigate necessary adaptations in the design of a mathematics course when it is transferred from one cultural environment to another. We focus on an elementary course in computational mathematics with Python taught at Lund University, Sweden, and at Soran University, Kurdistan/Iraq. This project holds two main parts. The first part elucidates how the necessary changes in tea

Cormac McCarthy's The Road takes place not before or during but after the end. The novel follows a man and his son as they seek to survive in what remains of the world after some unspecified cataclysmic event. There is almost nothing left: no society, no food, no animals, no hope. Many readers will feel that the question the novel poses is why anyone would wish to continue living under such circum

23 species of the lichen genus Caloplaca from Svalbard are described and/or discussed. The descriptions are natural language descriptions based on characters for each species coded into LIAS (Global Information System for Lichenized and Non-Lichenized Ascomycetes). A total of 37 Caloplaca species are listed for Svalbard, of which two species: C. elvebakkiana and C. scabrosa are described as new to