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Primär psykogen yrsel, i form av ångestsyndrom, och sekundär ”otogen ångest”, efter en period med vestibulär sjukdom, är bland de vanligaste orsakerna till långdragna yrselbesvär hos patienter i arbetsför ålder. Utan behandling kan besvären bli kroniska och leda till till långvarigt lidande. Ju tidigare sjukdomen upptäcks, desto bättre blir effekten av behandling.

Ribosome recycling factor (RRF) together with elongation factor G (EF-G) disassembles the post- termination ribosomal complex. Inhibitors of translocation, thiostrepton, viomycin and aminoglycosides, inhibited the release of tRNA and mRNA from the post-termination complex. In contrast, fusidic acid and a GTP analog that fix EF-G to the ribosome, allowing one round of tRNA translocation, inhibited

We have used suramin and brefeldin A to investigate the nature of a heparan sulphate proteoglycan that appears to recycle from the cell surface to intracellular compartments which synthesize new heparan sulphate chains. Suramin, which would block internalization and deglycanation of a putative recycling cell surface proteoglycan, markedly increases the yield of a membrane-bound proteoglycan with a

Pool boiling performance of NOVEC-649 was experimentally studied on microporous surfaces prepared by an electrochemical deposition method. Microporous structures contribute to large surface roughness values and provide large quantities of cavities ranging from several hundreds of nanometers to several microns for bubble nucleation. The results show that a maximum enhancement of 600% in heat transf

Changes in vegetation phenology are among the most sensitive biological responses to global change. While land surface phenological changes in the Northern Hemisphere have been extensively studied from the widely used long-term AVHRR (Advanced Very High Resolution Radiometer) data, current knowledge on land surface phenological trends and the associated drivers remains uncertain for the tropics. T

Reduced chemical kinetic mechanisms are essential for atmospheric chemistry modeling where the use of explicit kinetic schemes is too computationally demanding. By tailoring mechanisms to specific cases, the size of the mechanism can be kept small, without significant loss of accuracy in predictions of selected species’ concentrations. In the present work, we present small kinetic mechanisms tailo

Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have

The aim of this study was to find a solvent to replace N-methyl-2-pyrrolidone (NMP) in CO2 absorption systems containing the amine 2-amino-2-methyl-1-propanol (AMP), in order to reduce the health risks associated with handling, as NMP is reproductively toxic. Seven organic solvents were investigated: dimethyl sulfoxide (DMSO), 3-(dimethylamino)propionitrile (3DMAPN), 1-pentanol (1 P), propylene ca

Lean premixed combustion (LPC) is a promising technology for low-NOx emission, while it increases the risk of blowoff at the same time. Experiments and Large Eddy Simulations (LES) on swirl stratified lean-premixed CH4/air flames were performed to study the differences between the stable and near blowoff flame. The flow fields and instantaneous flame structures were measured by simultaneous Partic

As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is

Heat tolerance increases at higher acclimation temperatures in D. melanogaster, but not in D. subobscura. The two species represent separate lineages of the subgenus Sophophora of Drosophila with contrasting tropical African and temperate Palearctic evolutionary histories. D. melanogaster has five copies of the inducible hsp70 gene distributed in two clusters, named A (with two copies) and B (thre

Following the 7.5-Mw earthquake that occurred on 28 September 2018, a series of field surveys were performed to further understand the impacts of the resulting tsunami. Tsunamis initiated by strike-slip earthquakes are rare. Other factors are suspected to have contributed to this unusual tsunami. One of these factors was the subaerial landslides around Palu Bay, which were observed at several loca

Adequate reliability of measurement is a precondition for investigating individual differences and age-related changes in brain structure. One approach to improve reliability is to identify and control for variables that are predictive of within-person variance. To this end, we applied both classical statistical methods and machine-learning-inspired approaches to structural magnetic resonance imag

A total of 16 global chemistry transport models and general circulation models have participated in this study; 14 models have been evaluated with regard to their ability to reproduce the near-surface observed number concentration of aerosol particles and cloud condensation nuclei (CCN), as well as derived cloud droplet number concentration (CDNC). Model results for the period 2011-2015 are compar

Background: Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to examine in vivo associations between tau pathology, quantified with [18F]flortaucipir PET in regions corresponding to Braak stages, and atrophy across the Alzheime