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Gastrectomy causes bone loss in the rat: is lack of gastric acid responsible?
Total gastrectomy or resection of the acid-producing part of the stomach (fundectomy) in the rat induced a marked and rapid reduction in bone wet weight, ash weight, and density (expressed as ash weight in mg/mm3 bone). Bone volumes were also affected but not as much. The radius, sternum, tibia, and femur were studied. Three weeks after gastrectomy the bone ash weight was reduced by almost 30% and
Variety in knowledge sourcing, geography and innovation: Evidence from the ICT sector in Austria
It has been argued that innovation increasingly depends on external knowledge sources. It is still unclear if relations to particular knowledge sources or to a broad variety of sources matter for innovation. Also, there is a debate on the issue which spatial levels are most relevant. In this context, we investigate the importance for ICT firms in Austria of variety in knowledge sourcing for their
The effect of high or low dietary calcium on bone and calcium homeostasis in young male rats.
Young male rats (100 g body weight) were fed diets containing varying amounts of calcium. Body weight and bone development were studied together with various endocrine parameters, including blood levels of Ca2+, calcitonin, parathyroid hormone, vitamin D, and gastrin, and the enterochromaffin-like (ECL) cell-related parameters gastric mucosal histidine decarboxylase activity and histamine concentr
Growth of the parathyroid glands in omeprazole-treated chickens
BACKGROUND: Omeprazole, a long-acting inhibitor of gastric acid secretion, is able to increase the circulating concentrations of gastrin. Daily treatment with high doses of omeprazole cause sustained hypergastrinemia. Long-standing hypergastrinemia can be expected to exert numerous effects in the body. For instance, gastrin has been proposed to promote growth in the digestive tract and pancreas. T
Types of innovation, competencies of firms and external knowledge sourcing - Findings from selected sectors and regions of Europe
Many innovation studies have focused on a narrow concept of technological innovation, such as the generation of patents or the introduction of new products. The performance of firms, however, often depends on innovation defined from a broader perspective. This includes process, organizational, and market innovations as was pointed out already by Schumpeter and more recently by other scholars and t
Perturbations in blood Ca2+ do not affect the activity of rat stomach enterochromaffin-like cells.
BACKGROUND: Gastrin stimulates uptake of Ca(2)+ into bone and causes transient hypocalcemia, possibly by releasing a peptide hormone from enterochromaffin-like (ECL) cells, which are histamine- and peptidehormone-producing cells in the acid-producing part of the stomach. However, if ECL cells secrete a calciotropic hormone, it is to be expected that their activity is affected by the serum Ca(2)+ c
Chicken parathyroid hormone gene expression in response to gastrin, omeprazole, ergocalciferol, and restricted food intake.
Treatment with omeprazole, a long-acting proton pump inhibitor of acid secretion, induces hypergastrinemia. In chickens, omeprazole induces growth not only of the acid-producing mucosa (probably reflecting the trophic action of gastrin), but also of the parathyroid glands (hypertrophy + hyperplasia), while suppressing bone density and body weight gain without affecting blood calcium. The first par
Rat stomach ECL-cell histidine decarboxylase activity is suppressed by ergocalciferol but unaffected by parathyroid hormone and calcitonin.
The ECL cells are peptide hormone-producing cells, rich in histamine and chromogranin A (CGA)-derived peptides, that operate under the control of gastrin. Gastrin and the ECL cells form a functional unit, the gastrin-ECL-cell axis. The aims of the present study were to examine (1) if calcitonin (CT), parathyroid hormone (PTH) and vitamin D affect the gastrin-ECL-cell axis (by measuring the activit
Inshore Commercial Fisheries in the Service Economy : Session 1 Small-Scale Fisheries Research - towards sustainable fisheries using a multi-entry perspective
The study frames a traditional industry in transition with the aim to understand the ways in which a work-identity is formed in the service economy along the west coast of Sweden. More specifically, we want to understand how diversified inshore commercial fisheries are discursively established and negotiated as a service enterprising subject in three everyday relationships; authorities, customers
Qualitative questionnaires as a method for information studies research
Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2.
Proteinase-activated receptors (PARs) are activated by proteolytic removal of a short amino terminal peptide, thus exposing a new amino terminus that functions as a tethered ligand that activates the receptor. With the aim to identify and study potential activators of PAR-2 we have developed a new method to measure proteolytic cleavage of PARs. PAR-2 was tagged with the insulin C-peptide that upon
Extent of myocardium at risk for left anterior descending artery, right coronary artery, and left circumflex artery occlusion depicted by contrast-enhanced steady state free precession and T2-weighted short tau inversion recovery magnetic resonance imaging
Background - Contrast-enhanced steady state free precession (CE-SSFP) and T2-weighted short tau inversion recovery (T2-STIR) have been clinically validated to estimate myocardium at risk (MaR) by cardiovascular magnetic resonance while using myocardial perfusion single-photon emission computed tomography as reference standard. Myocardial perfusion single-photon emission computed tomography has bee
Empowering interviews : narrative interviews in the study of information literacy in everyday life settings
The main aim of this paper is to discuss how, within a sociocultural perspective, to design and conduct interviews for studying information literacy in everyday life. A methodological framework combining a sociocultural perspective with a narrative interview method is developed, in which visual tools are used to engage interviewees as active participants in the interview situation. This method was
Occupational nitrile glove allergy caused by Pigment Blue 15
Several cases of undesirable effects caused by methacrylate ultraviolet-curing nail polish for non-professional use
Background: Ultraviolet (UV)-curing nail polishes based on acrylates or methacrylates are currently also available for non-professional use. The Swedish Medical Products Agency recently prohibited one brand of UV-curing polish, because several consumers reported undesirable effects after using it. Objectives: To investigate whether consumers with undesirable effects after using the UV-curing nail
Gender differences in knee abduction during weight-bearing activities : A systematic review and meta-analysis
Background Increased knee abduction during weight-bearing activities is suggested to be a contributing factor for the high knee injury risk reported in women. However, studies investigating gender difference in knee abduction are inconclusive. Objective To systematically review gender-differences in knee abduction during weight-bearing activities in individuals with or without knee injury. Methods
Precarious employment is a risk factor for poor mental health in young individuals in Sweden : A cohort study with multiple follow-ups
Background: The globalisation of the economy and the labour markets has resulted in a growing proportion of individuals who find themselves in a precarious labour market situation, especially among the young. This pertains also to the Nordic countries, despite their characterisation as well developed welfare states with active labour market policies. This should be viewed against the background of
Intact endothelial and contractile function of coronary artery after 8 hours of heart preservation
Objectives. The aim of the study was to investigate if adequate preservation of coronary artery endothelium-dependent relaxation and contractility may be obtained after 8 hours of non-ischemic heart preservation. Design. Porcine hearts were perfused for 8 hours at 8 °C, either in cycles of 15 minutes perfusion and 60 minutes non-perfusion, or by continuous perfusion. The perfusate consisted of a c