Protein dynamics on the micro- to millisecond time scale is increasingly found to be critical for biological function, as demonstrated by numerous NMR relaxation dispersion studies. Methyl groups are excellent probes of protein interactions and dynamics because of their favorable NMR relaxation properties, which lead to sharp signals in the H-1 and C-13 NMR spectra. Out of the six different methyl

It is well known that one fragility fracture begets another. Fracture Liaison Services have been shown to narrow the care gap that exists in the care of patients with fragility fractures. A secondary fracture prevention programme "OPTIMAL" (Osteoporosis Patient Targeted and Integrated Management for Active Living) has been in existence in the public restructured hospitals and polyclinics of Singap

Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson's disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin is modified by oxidation in vivo, and, in addition, in vitro by deamidation of specific NGR-mo

Background: Unilateral vestibular deafferentation (uVD), as performed in vestibular schwannoma surgery, results in a chronic vestibular deficit, though most of the insufficiency can be compensated by other sensory input. By vestibular training (prehabituation) performed before surgery, motor adaptation processes can be instigated before the actual lesion. The adaptation processes of the altered se

We present a Bayesian ideal observer model that estimates observer translation and rotation from optic flow and an extra-retinal eye movement signal. The model assumes a rigid environment and noise in velocity measurements, and that eye movement provides a probabilistic cue for rotation. The model can simulate human heading perception across a range of conditions, including: translation with simul

In this study, 10 hematologists and 10 lung oncologists were interviewed regarding the information they provide to patients in four situations of uncertainty: determining the treatment that is in the patient's best interest; recurrence or progression of the patient's disease; determining when to withdraw life-prolonging treatment; discussing death, addressing questions such as whether the patient

This paper presents the co-design of a class-D digitally-controlled oscillator (DCO) and a low-dropout voltage regulator (LDO) generating the supply voltage for the DCO. Despite the high intrinsic supply pushing of the class-D oscillator topology, the LDO noise has only a very marginal impact on the DCO phase noise. The class-D DCO and LDO have been integrated in a 65nm CMOS process without any th

Popular Abstract in Swedish Mikroti är en medfödd avvikelse där ytterörat inte utvecklats normalt. Defekten kan variera från att örat nästan är normalt till att det saknas helt och hållet, s.k. anoti. I Sverige inträffar detta i c:a 2 fall per 100 000 nyfödda. Pojkar drabbas i större utsträckning och höger sida är den vanligaste. Båda sidor drabbas i c:a en tiondel av fallen. Förträngning av yttreMicrotia is a congenital malformation where the auricle is not fully developed. In some cases the malformation is complete and the auricle is absent. In Sweden the incidence of microtia is about 2 per 10,000 births. Reconstruction of the external ear is possible by using autologous rib cartilage in three surgical steps: rib cartilage transplantation, ear elevation and final adjustments. Although t

A measurement of the production cross-section for top quark pairs (t (t) over bar) in pp collisions at root s = 7 TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in two different topologies: single lepton (electron e or muon mu) with large missing transverse energy and at least four jets, and dilepton (ee, mu mu or e mu) with large mis

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, a

The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of root s = 7 TeV corresponding to an integrated luminosity of 38 pb(-1). Jets are reconstructed with the anti-k(t) algorithm with distance parameters R = 0.4 or R = 0.6. Jet energy and angle corrections are determined fr

Seismic isolation is a strategy to reduce damage of structures exposed to devastating earthquake excitations. Isolation systems, applied at the base of buildings, lower the fundamental frequency of the structure below the range of dominant frequencies of the ground motion as well as allow to dissipate more energy during structural vibrations. The effectiveness of the base-isolated buildings in dam

Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending on inhibition of myosin phosphatase

This article focuses on the Swedish middle distance runner Gunder Hägg (1918–2004). The peak of his career coincided with WWII, and in the Summer of 1942 he broke 10 out of his 15 world records. The year after, he made a much appreciated and successful running tour to the US. This made Hägg the first real media sports star in Sweden. The article analyses the representation of Hägg in different med

There is a paucity of diagnostic instruments for adults with autism spectrum disorder (ASD). This study evaluates the psychometric properties of the Swedish version of the Ritvo Autism and Asperger Diagnostic Scale-Revised (RAADS-R), an 80-item self-rating scale designed to assist clinicians diagnosing ASD in adults. It was administered to 75 adults with ASD and 197 comparison cases. Also, a subse

Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib. A collection of clinical Haemophilus influenzae isolates was tested and the majority of encapsulated and unencapsulated bound F

Graphics processing units supporting tessellation of curved surfaces with displacement mapping exist today. Still, to our knowledge, culling only occurs after tessellation, that is, after the base primitives have been tessellated into triangles. We introduce an algorithm for automatically computing tight positional and normal bounds on the fly for a base primitive. These bounds are derived from an

A two-dimensional numerical model of nearshore waves, currents, and sediment transport was developed. The multi-directional random wave transformation model formulated by Mase [Mase, H., 2001. Multidirectional random wave transformation model based on energy balance equation. Coastal Engineering Jounnal 43(4), 317-337.] based on an energy balance equation was employed with an improved description