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This thesis is focused on two globally prevalent diseases: i) non-alcoholic fatty liver disease (NAFLD) and ii) type 2 diabetes (T2D), with an overall aim of improving prediction and causal inference in the context of these conditions. Our projects were mainly conducted using IMI DIRECT and UK Biobank datasets including multi-omics data, extensive environmental exposures, and biological intermedia
The movement of DOM from terrestrial to aquatic systems is a globally significant flux affecting both carbon sequestration and CO2 emissions. Here, DOM dynamics were investigated in terrestrial and aquatic systems within the context of this carbon flux. The overall aim was to investigate the source and chemistry of DOM and determine how chemistry is affected by microbial processing of DOM. In the
The inclusive J/ψ elliptic (v2) and triangular (v3) flow coefficients measured at forward rapidity (2.5 < y < 4) and the v2 measured at midrapidity (|y| < 0.9) in Pb-Pb collisions at sNN = 5.02 TeV using the ALICE detector at the LHC are reported. The entire Pb-Pb data sample collected during Run 2 is employed, amounting to an integrated luminosity of 750 μb−1 at forward rapidity and 93 μb−1 at mi
The measurement of the azimuthal-correlation function of prompt D mesons with charged particles in pp collisions at s=5.02TeV and p–Pb collisions at sNN=5.02TeV with the ALICE detector at the LHC is reported. The D , D +, and D ∗ + mesons, together with their charge conjugates, were reconstructed at midrapidity in the transverse momentum interval 3
A search for new-physics resonances decaying into a lepton and a jet performed by the ATLAS experiment is presented. Scalar leptoquarks pair-produced in pp collisions at s = 13 TeV at the Large Hadron Collider are considered using an integrated luminosity of 139 fb−1, corresponding to the full Run 2 dataset. They are searched for in events with two electrons or two muons and two or more jets, incl
This paper presents a search for new heavy particles decaying into a pair of top quarks using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of s = 13 TeV with the ATLAS detector at the Large Hadron Collider. The search is performed using events consistent with pair production of high-transverse-momentum top quarks and their subsequent decays into the fully hadronic f
Background: Activation delay in ischemic myocardium has been found to contribute to J-wave appearance and to predict ventricular fibrillation (VF) in experimental myocardial infarction. However, the role of ischemia-related repolarization abnormalities in J-wave generation remains unclear. Objectives: The objective of our study was to assess a contribution of myocardial repolarization changes to J
In situ CO2 and CO measurements from five Integrated Carbon Observation System (ICOS) atmosphere stations have been analysed together with footprint model runs from the regional Stochastic Time-Inverted Lagrangian Transport (STILT) model to develop a dedicated strategy for flask sampling with an automated sampler. Flask sampling in ICOS has three different purposes, namely (1) to provide an indepe
BACKGROUND Recently, a technique has been developed to use magnetic resonance enterography (MRE) for the evaluation of small bowel motility. The hypothesis was that assessment of the motility index (MI) should reflect differences in motility between clinical conditions. AIM To aim of the present observational, cross-sectional study was to evaluate the use of the MI in daily clinical practice. METH
Introduction Receiving Bacille Calmette-Guérin (BCG)-Denmark vaccine at birth has been associated with ∼40% reductions in all-cause neonatal mortality. We evaluated determinants of BCG skin reaction characteristics by age 2 months and tested the association with subsequent mortality. Methods Prospective observational study amalgamating five trials providing BCG-at-birth that were conducted between
In a joint experimental and theoretical study on metallic TbSi2 nanowires, we observe a continuous crossover from a two-dimensional (2D) to a quasi-one-dimensional (1D) electronic structure by reduction of the nanowire width. The nanowires were grown by self-organization on vicinal Si(111) substrates denoted by the Miller indices (hhk). Their electronic structure was analyzed by angle-resolved pho
This Letter describes a search for narrowly resonant new physics using a machine-learning anomaly detection procedure that does not rely on signal simulations for developing the analysis selection. Weakly supervised learning is used to train classifiers directly on data to enhance potential signals. The targeted topology is dijet events and the features used for machine learning are the masses of
Autoimmune hepatitis (AH) and primary biliary cirrhosis (PBC) are autoimmune diseases (AIDs) targeting cellular components of the liver. Being rare diseases, limited data are available about familial risks among these AIDs (concordant) or between them and other AIDs (discordant). We aimed to carry out an unbiased study on these AIDs based on medically diagnosed patients. We collected data on patie
Drawing on the conceptualisation of motility as the capacity to be mobile, this paper employs statistical and GIS-based analyses to explore the associations between travel mode choice and mobility-related attitudes, skills and opportunities to access transport modes. The study builds on survey data and spatial data from three urban contexts of Beijing, Gothenburg and Malmo to analyse both individu
A combined two-levels control method has been developed and tested on a long term operation of a two-phases pilot-scale anaerobic process for the concurrent production of volatile fatty acids, hydrogen and methane. The latter was designed for the treatment of food waste of urban origin (namely, the organic fraction of municipal solid waste). The optimized control method was set on the base of the
