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Context: Prototyping is an established practice within product and user interface design that is also used as a requirements engineering (RE) practice within agile development. Even so, there is a lack of theory on prototyping.Aims: Our main research objective is to support practitioners in improving on their prototyping practices.Method: We have designed a model that describes key aspects of the
Context: Software selection in large-scale software development continues to be ad hoc and ill-structured. Previous proposals for software component selection tend to be technology-specific and/or do not consider business or ecosystem concerns.Objective: Our main aim is to develop an industrially relevant technology-agnostic method that can support practitioners in making informed decisions when s
This study examines the ideology of the nation-building process in the so-called Donetsk and Luhansk People's Republics. The key features of this process are uncovered through a discourse analysis of school textbooks published in the People's Republics and in Transnistria, and of the 'Russian Donbas' ideology. This is compared to the history and interpretations of the concept of 'Novorossiya'. Thi
Durable and high-performing anion exchange membranes (AEMs) are central components in alkaline water electrolyzers and fuel cells. Here, we have pursued a synthetic strategy where heteroatom-free polymer backbones are functionalized with alkali-stable dimethyl piperidinium (DMP) cations via flexible spacers. We achieved this design by synthesizing a trifluorobenzophenone monomer carrying a piperid
Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expressi
BACKGROUND: Screening for abdominal aortic aneurysm (AAA) in 65-year-old males reduces aneurysm related mortality. Infrarenal aortic diameter (IAD) has been shown to correlate to body surface area (BSA) which could influence diagnostic criteria for AAA. This study investigates whether AAA growth rates are also dependent on BSA, as that might have potential effects on surveillance of small AAAs.MET
AIMS: To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.METHODS: Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glyca
This thesis investigates the psychological dimensions of sense perception in the works of two key poets in the British Romantic tradition - William Wordsworth and Samuel Taylor Coleridge - using a combination of traditional close reading and a newer psychobiographical approach. The thesis proposes that Wordsworth's and Coleridge's works can be seen as staging a dialogue between two mutually incomp
PURPOSE: The deep breathing test (DBT) is a sensitive test of cardiovagal function. The aim of this study was to explore associations between physical activity and sedentary time, measured by accelerometer, and autonomic function, using DBT.METHODS: In the Swedish Cardio-Pulmonary bioImage Study, men and women aged 50-64 were randomly invited from the general population. A total of 4325 subjects w
BACKGROUND: Peripheral artery disease is considered to be a manifestation of systemic atherosclerosis with associated adverse cardiovascular and limb events. Data from previous trials have suggested that patients receiving clopidogrel monotherapy had a lower risk of cardiovascular events than those receiving aspirin. We wanted to compare clopidogrel with ticagrelor, a potent antiplatelet agent, in
BACKGROUND: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-te
