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Purpose: The glycosaminoglycans chondroitin sulfate (CS) and hyaluronic acid (HA) are important for the normal function of articular cartilage, and changes of their sulfation and concentration may play a role in the pathogenesis of osteoarthritis (OA). Therefore, these glycans may be clinically useful as biomarkers in OA management. The purpose of this study was to analyze the CS and HA pattern in
Purpose: Extracellular proteins such as aggrecan may be primed with specific glycan-patterns which result in their degradation, and hence may play a role in the pathogenesis of osteoarthritis (OA). To be able to use glycans as molecular biomarkers, the method of analysis of these molecules needs to be validated. The primary aim of this study was to validate quantitative high performance liquid chr
PurposeThe reuse of timber building parts, when designing new buildings, has become a topic of increasing discussion as a proposed circular solution in support of sustainable development goals. Designers face the difficulty of identifying and applying different design strategies for reuse due to multiple definitions, which are used interchangeably. The purpose of this study is to propose a taxonom
Background: 18F-Fluorodeoxyglucose positron emission combined with computed tomography (FDG-PET/CT) has been proposed to improve preoperative staging in patients with bladder cancer subjected to radical cystectomy (RC). Objective: Our aim was to assess the accuracy of FDG-PET/CT for lymph node staging ascertained at the multidisciplinary tumour board compared to lymph node status in the surgical l
The combination of digital breast tomosynthesis (DBT) with other imaging modalities has been investigated in order to improve the detection and diagnosis of breast cancer. Mechanical Imaging (MI) measures the stress over the surface of the compressed breast, using a pressure sensor, during radiographic examination and its response has shown a correlation with the presence of malignant lesions. Thu
We consider partitioned time integration for heterogeneous coupled heat equations. First and second order multirate, as well as time-adaptive Dirichlet-Neumann Waveform relaxation (DNWR) methods are derived. In 1D and for implicit Euler time integration, we analytically determine optimal relaxation parameters for the fully discrete scheme. We test the robustness of the relaxation parameters on the
Metal halide perovskite based tandem solar cells are promising to achieve power conversion efficiency beyond the theoretical limit of their single-junction counterparts. However, overcoming the significant open-circuit voltage deficit present in wide-bandgap perovskite solar cells remains a major hurdle for realizing efficient and stable perovskite tandem cells. Here, a holistic approach to overco
Introduction and Hypothesis: The Manchester procedure is a classic native tissue prolapse technique with low recurrence and low complication rate. vNOTES (vaginal natural orifice transluminal endoscopic surgery) is a vaginal approach to enter the intra or retroperitoneal space, with the guidance of endoscopic visualization. Different studies have shown women to prefer uterus-preserving correction
Industrial symbiosis can move us closer to a circular economy and enable efficient and sustainable use of resources. Its potential has however been far from realized, and to increase our understanding of why that is, we investigate drivers, barriers, and outcomes associated with both broadly defined environmental sustainability initiatives and industrial symbiosis from an organizational context pe
At the dissolution of solid anhydrous thallium(III) trifluoromethanesulfonate, Tl(CF3SO3)3, or thallium(III) trifluoroacetate, Tl(CF3COO)3, in dimethylsulfoxide (dmso) or N,N,N’,N’-tetramethylurea (tmu), intensely red-colored complexes are formed. This red thallium complex is stable for years in dmso, while it is reduced fairly rapidly to thallium(I) in tmu with a half-life time of an hour. At the
The goal of person text-image matching is to retrieve images of specific pedestrians using natural language. Although a lot of research results have been achieved in persona text-image matching, existing methods still face two challenges. First,due to the ambiguous semantic information in the features, aligning the textual features with their corresponding image features is always tricky. Second,
Extreme environmental conditions make soils of the hyper-arid Atacama Desert one of the most hostile habitats for life on the planet. During the short intervals of moisture availability that occur, it remains unresolved how soil microorganisms physiologically respond to such dramatic environmental changes. Therefore, we simulated a precipitation event – without (H2O) and with (H2O + C) labile carb
Background: Intra-tumour heterogeneity (ITH) causes diagnostic challenges and increases the risk for disease recurrence. Quantification of ITH is challenging and has not been demonstrated in large studies. It has previously been shown that deep learning can enable spatially resolved prediction of molecular phenotypes from digital histopathology whole slide images (WSIs). Here we propose a novel me
Att vara trans på olika sätt är ingen nödsituation och behöver inte vara dramatiskt. I stället för att enbart reagera i stunden kan politiker, rektorer, lärare, kuratorer, skolsköterskor och andra vuxna skapa en skola där färre spontana lösningar krävs eftersom det finns ett genomtänkt pedagogiskt och administrativt arbete, det som kallas ”whole-of-school approach” (Bartholomaeus & Riggs, 2017Being trans in different ways is not an emergency and does not have to be dramatic. Instead of reacting only in the moment, politicians, principals, teachers, counselors, nurses and other adults can create a school where fewer spontaneous solutions are needed because there is well thought-out pedagogical and administrative work, what is called the 'whole-of-school approach' (Bartholomaeus & Ri
Good hygiene, in both health care and the community, is central to containing the rise of antibiotic resistance, as well as to infection control more generally. But despite the well-known importance, the ecological mechanisms by which hygiene (or other transmission control measures) affect the evolution of resistance remain to be elucidated. Using metacommunity ecology theory, we here propose that
Oil-in-water emulsions containing N,N-diethyl-3-methylbenzamide (DEET) were developed aiming to extend the sustained release of the active compound, by using two oppositely charged nanomaterials, namely silica nanoparticles (SiNP) and cationic cellulose nanofibrils (CCNF), as stabilizers, and a mixture of food-grade nonionic surfactants to avoid precipitation by electrostatic aggregation. The form
This work presents a mechanistic understanding of the synthesis of small (<3 nm) gold nanoparticles in a nontoxic, eco-friendly, and biodegradable eutectic mixture of choline chloride and urea (reline) without the addition of external reducing or stabilization agents. Reline acts as a reducing agent by releasing ammonia (via urea hydrolysis), forming gold nanoparticles even at trace ammonia concen
En åpen og opplyst offentlig samtale er en forutsetning for et velfungerende demokrati. Dette idealet fordrer at borgere i stor grad tolererer meningsmotstandere fremfor å utvikle fiendtlige holdninger til dem man er uenig med. En rekke studier fra USA har imidlertid vist at borgere i økende grad er fiendtlig innstilt til velgere de er politisk uenig med (Iyengar et al., 2019). Dette fenomenet er
