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In this article, we review recent theoretical work that has complemented the extensive experimental data available for multicopper oxidases (MCO) and led to the elucidation of the reaction mechanism of this class of enzymes. The MCOs couple four one-electron oxidations of substrates at the mononuclear type 1 copper (Cu-T1) site with the four-electron reduction of dioxygen at the trinuclear copper
Urate oxidase transforms uric acid to 5-hydroxyisourate without the help of cofactors, but the catalytic mechanism has remained enigmatic, as the protonation state of the substrate could not be reliably deduced. We have determined the neutron structure of urate oxidase, providing unique information on the proton positions. A neutron crystal structure inhibited by a chloride anion at 2.3 Å resoluti
The harvest mouse (Micromys minutus) occurs throughout most of continental Europe. There are also two isolated and recently discovered populations on the Scandinavian peninsula, in Sweden and Norway. Here, we investigate the origin of these populations through analyses of mitochondrial DNA. We found that the two populations on the Scandinavian peninsula have different mtDNA haplotypes. A compariso
Hur gestaltades den diskursiva katolska manligheten i Skandinavien under konfessionalismens tidevarv? Och hur förhöll sig de katolska manlighetsidealen till de idéer om manlighet som framträdde inom nordisk folkkyrkokristendom vid samma tid? Dessa frågor har utgjort utgångspunkten för min undersökning om mansideal och manlighetskonstruktioner hos katolska präster, ordensmän och manliga konvertiter
Recension av R. G. Grant (red.), Krigsherrar. Militärhistoriens främsta befälhavare och Richard Holmes (red.), Stora boken om andra världskriget. Från blixtkrig till Hiroshima.
We report results from a large-scale nutrient fertilization experiment along a "megadiverse" (154 unique species were included in the study) 3,000-m elevation transect in the Peruvian Andes and adjacent lowland Amazonia. Our objectives were to test if nitrogen (N) and phosphorus (P) limitation shift along this elevation gradient, and to determine how an alleviation of nutrient limitation would man
There has been much debate on the topic of whether stricter environmental regulations can promote environmental performance and economic performance at the same time. Different researchers have used different indicators to measure environmental performance and economic performance in their empirical studies. However, it is a surprise that few studies have checked the relationship between environme
Studies have shown that microRNAs (miRNAs) are involved in the malignant progression of human cancer. However, little is known about the potential role of miRNAs in breast carcinogenesis. miR-124 expression in breast cancer tissue was measured by quantitative real-time PCR (qRT-PCR). Target prediction algorithms and luciferase reporter gene assays were used to investigate the target of miR-124. Br
Billions of animals migrate each year. To successfully reach their destination, migrants must have evolved an appropriate genetic program and suitable developmental, morphological, physiological, biomechanical, behavioral, and life-history traits. Moreover, they must interact successfully with biotic and abiotic factors in their environment. Migration therefore provides an excellent model system i
OBJECTIVE: A main purpose of physical education (PE) in school is to promote future health. However, there is very limited evidence of the effects of PE on the adult health. We hypothesized that a low performance in PE was associated with an increased risk of health impairment by middle age. METHODS: We performed a cohort study in a community-based setting in Sweden spanning over three decades. W
Cerebral edema is a common complication following moderate and severe traumatic brain injury (TBI), and a significant risk factor for development of neuronal death and deterioration of neurological outcome. To this date, medical approaches that effectively alleviate cerebral edema and neuronal death after TBI are not available. Glucagon-like peptide-1 (GLP-1) has anti-inflammatory properties on ce
TV-on-Demand services have become one of the most popular Internet applications that continuously attracts high user interest. With rapidly increasing user demands, the existing network conditions may not be able to ensure a low start-up delay of video playback. Prefetching has been broadly investigated to cope with the start-up latency problem, which is also known as user perceived latency. In th
Context. The Gaia satellite will observe about one billion stars and other point-like sources. The astrometric core solution will determine the astrometric parameters (position, parallax, and proper motion) for a subset of these sources, using a global solution approach which must also include a large number of parameters for the satellite attitude and optical instrument. The accurate and efficien
Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potentia
Peptides derived from apolipoprotein B (apoB)-100 have been previously used in vaccine preparations to treat atherosclerosis. Such vaccines have been shown to reduce atherosclerotic plaque development by 50 % in experimental animals, and this effect is associated with induction of T helper (Th)2 immune responses. In this study we immunised apolipoprotein E-deficient (apoE(-/-)) mice with apoB-100-
Genome-wide association studies have identified common variants that only partially explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from 1,376 French individuals, we identified 16,360 SNPs nominally associated with T2D and studied these SNPs in an independent sample of 4,977 French individuals. We then selected the 28 best hits for replication in 7,698 Danish
