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Protein degradation is a regulated process that reshapes the proteome and generates bioactive peptides. Peptidomics and degradomics enables large-scale measurement of these peptides, yet most data analyses approaches treat peptides as isolated endpoints rather than intermediates produced by sequential cleavage. Here, we introduce degradation graphs, a probabilistic framework that represents proteo
Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2 (SNAI2) is frequently amplified in prostate cancer, it is epigenetically silenced in this disease, with dynamic changes in SNAI2 levels showing distin
IMPORTANCE: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.OBJECTIVES: To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate
How do bribes and lobbying distort judgment? In our experiment, referees are tasked with judging a worker’s performance, and awarding a bonus to workers who score above a certain threshold. We find that bribes and lobbying are both distortionary, but in different ways. Whereas lobbying increases the number of workers receiving a bonus, bribes weaken the relationship between performance and success
We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGET
PURPOSE: Obesity is associated with a wide range of chronic illnesses and disabilities familiar to rehabilitation researchers and practitioners. Obesity discourse in the area of rehabilitation science and practice is limited.METHOD: A meeting of rehabilitation researchers, practitioners, industry and decision makers was held for the purpose of identifying research and practice priorities in the ar
Weight stigma, defined as pervasive misconceptions and stereotypes associated with higher body weight, is both a social determinant of health and a human rights issue. It is imperative to consider how weight stigma may be impeding health promotion efforts on a global scale. The World Obesity Federation (WOF) convened a global working group of practitioners, researchers, policymakers, youth advocat
Ett förändrat klimat med mer intensiva regn och längre torrperioder har gjort sötvatten till en alltmer värdefull och sårbar resurs. Vattenbrist förekommer i dag i många delar av världen, även i områden där det tidigare inte varit ett problem, såsom i Sverige. Minskad vattenan-vändning kan bidra till att reducera efterfrågan, men endast upp till en viss gräns. För att säkerställa en långsiktig ochWith climate change causing more intense rainfall events and prolonged droughts, freshwa-ter resources are increasingly under pressure worldwide, including in regions such as Sweden where water scarcity was previously unexpected. While water conservation can reduce de-mand to some extent, long-term water security requires alternative and resilient water sources. Wastewater represents a reliable so
The introduction of the Environmental Transmission Electron Microscope (ETEM) has revolutionized scientific studies by allowing in-situ studies of nano and angstrom scale samples in varying environments. In combination with the introduction of the Microelectromechanical Systems (MEMS) chip the ETEM has become a powerful tool for high resolution imaging of material interaction. However, the MEMS ch
Projekt Beta är ett pilotprojekt inom ramen för CoAction Lund. CoActions mål är att göra Lund klimatneutral till 2030. Projekt Beta innebär att Lunds kommunala fastighetsbolag (LKF) och parkeringsbolag (LKP) sammankopplas i en energigemenskap via ett internt icke-koncessionspliktigt nät (IKN). Detta använder företaget ViaEuropa som ett pilotprojekt för teknikbevis av energigemenskaper. Genom en faProject Beta is a pilot project within CoAction in Lund. CoAction is a collaboration with a goal to make Lund climate neutral by 2030. Project Beta connects Lund´s municipal housing company (LKF) and Lund parking company (LKP) into an energy community via an internal non-concession network (IKN). This project is used by the company ViaEuropa as a pilot för a proof of concept for energy communities
Background: Following the results of the MANDARA trial, this real-life study aimed at comparing the effectiveness and safety profile of mepolizumab versus benralizumab in a European EGPA cohort. Methods: We conducted a retrospective observational comparative study including EGPA patients, who received mepolizumab or benralizumab at the asthma dose. Patients were matched 1:1 by sex, age, BVAS and o
Studying the composition of exoplanets is one of the most promising approaches to observationally constrain planet formation and evolution processes. However, this endeavour is complicated for small exoplanets by the fact that a wide range of compositions are compatible with their observed bulk properties. To overcome this issue, we identify triangular regions in the mass-radius space where part o
Tuberculosis (TB) patients who are diagnosed but not registered and initiated on TB treatment are categorised as initial loss to follow-up (ILTFU). ILTFU is a key driver of morbidity and mortality associated with TB and is a contributing factor to high TB transmission rates. LINKEDin was a quasi-experimental study which evaluated two specific interventions for reducing ILTFU in three high-TB burde
The ALICE Collaboration presents a new suite of jet substructure measurements in Pb–Pb and pp collisions at a center-of-mass energy per nucleon pair sNN=5.02 [Figure presented]. These measurements provide access to the internal structure of jets via the momentum and angle of their constituents, probing how the quark–gluon plasma modifies jets, an effect known as jet quenching. Jet grooming additio
Background: Breathlessness on exertion is a common, distressing, and limiting symptom that can be quantified on incremental cardiopulmonary exercise testing (CPET) using normative reference equations. Research Question: Is the breathlessness abnormality best uncovered and assessed at symptom limitation (peak exercise) compared with submaximal exercise intensities? Study Design and Methods: This wa
Introduction: Oesophageal resection carries significant morbidity and mortality. Artificial intelligence (AI) advances in medical research enable enhanced predictions, flexibility, and interpretability, especially for complex interactions and nonlinear relationships. Material and methods: We used a register-based case-control design nested within prospectively collected data from the Swedish Natio
