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Introduction: HIV guidelines recommend switching from a three-drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long-term outcomes of adults with HIV RNA <50 copies/ml who switched to DTG+3TC or a guideline-recommended 3DR between July 2019 and May 2023 in routine clinical c

The pathophysiology underlying various manifestations of cerebral small-vessel disease (cSVD) remains poorly understood. Using high-throughput proteomics, we identified common and distinct proteomic signatures of white matter lesions (WMLs), microbleeds, infarcts and their subtypes, measured in 1,670 living patients. Across all cSVD manifestations, markers of extracellular matrix dysregulation and

Light chain monoclonal gammopathy of undetermined significance (LC-MGUS) is an asymptomatic precursor of multiple myeloma (MM) and related disorders defined by abnormal free light chain (FLC) testing. Recently, revised FLC reference intervals were proposed by the iStopMM study group. We evaluated their performance in a large population-based cohort. MGUS cases were identified from the Danish Lymph

Correlations between event-by-event fluctuations of anisotropic flow harmonics are measured in Pb-Pb collisions at a center-of-mass energy per nucleon pair of 5.02 TeV, as recorded by the ALICE detector at the LHC. This study presents correlations up to the hexagonal flow harmonic v6, which was measured for the first time. The magnitudes of these higher-order correlations are found to vary as a fu

This paper presents the primary charged-particle multiplicity distributions in proton–lead collisions at a centre-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV. The distributions are reported for non-single diffractive collisions in different pseudorapidity ranges. The measurements are performed using the combined information from the Silicon Pixel Detector and the Forward Multiplic

The coherent J/ ψ photoproduction cross section is measured for the first time at midrapidity in peripheral to semicentral Pb−Pb collisions at sNN=5.02 TeV. The centrality differential cross section d σ /d y is reported for the centrality range 40–90%, together with the doubly-differential cross section d2 σ /d y d p T, extracted in two peripheral centrality classes. The J/ ψ mesons are reconstruc

This work reports femtoscopic correlations of p-−p(p‾-−p‾) and p−−d(p‾-−d‾) pairs measured in Pb–Pb collisions at center-of-mass energy per nucleon sNN = 5.02 TeV in the ALICE Collaboration. A fit to the measured proton-proton correlation functions allows one to extract the dependence of the nucleon femtoscopic radius of the particle-emitting source on the pair transverse mass (mT) and on the aver

This chapter provides a normative analysis of the CJEU’s centre of gravity theory in legal basis litigation, exposing a number of flaws in its application and presenting suggestions for improvement. The chapter discusses the difficulties in the delimitation of competences under the current constitutional setup, the CJEU’s inconsistencies in applying the criteria of aim and content under the centre

Membrane channels are central to bladder function, yet current understanding is shaped disproportionately by a few well-studied families such as TRPA1 and TRPV1. To provide a more balanced view, this review analyzed emerging human transcriptomic datasets to identify the channels most highly expressed in the urinary bladder and examined how they remodel in bladder outlet obstruction and denervation

BACKGROUND: Accreditation of cancer centres aims to deliver high-quality, person-centered care and underscores the integration with education, research, and innovation. Over the past decade, cancer centres in the Nordic countries have engaged in accreditation processes through the Organisation of European Cancer Institutes (OECI).OBJECTIVE: This study provides an overview of a rapidly evolving lan

The bioeconomy promises to replace fossil resources with renewable biomass, assigning forests a central role in sustainability transitions. This dissertation tests that promise against the empirical record, using SWINNO, a database of significant commercialized innovations in Sweden linked to firm-register data, to trace fifty years (1970–2021) of forest-related innovation output. Four papers inve

The momentum-differential invariant cross sections of π0 and η mesons are reported for pp collisions at = 13 TeV at midrapidity (|y| < 0.8). The measurement is performed in a broad transverse-momentum range of 0.2 < pT< 200 GeV/c and 0.4 < pT< 60 GeV/c for the π0 and η, respectively, extending the pT coverage of previous measurements. Transverse-mass-scaling violation of up to 60% at low transvers

This paper presents the measurement of the isolated prompt photon inclusive production cross section in pp and p–Pb collisions by the ALICE Collaboration at the LHC. The measurement is performed in p–Pb collisions at centre-of-mass energies per nucleon pair of sNN=5.02TeV and 8.16 TeV, as well as in pp collisions at s=5.02TeV and 8 TeV. The cross section is obtained at midrapidity (|y|20GeV/c. How

Despite its importance, rural groundwater quality in Rwanda remains insufficiently monitored. This study aimed to investigate the groundwater quality, its health implications as well as how management can be improved to reduce the health risks of rural boreholes in the Nyagatare district in Rwanda. In total 61 boreholes were visited and 48 groundwater samples were collected. Analysis was conducted

CD4 tissue-resident memory T cells (TRM) are crucial adaptive immune components involved in preventing influenza A virus (IAV) infection. Despite their importance, their physiological role in the upper respiratory tract, the first site of contact with IAV, remains unclear. Here, we find that, after IAV infection, antigen-specific CD4 TRM persist in the nasal tissue (NT) compartment after infection

AIOLIA deliverable 2.2 contains a selection of ethical principles and values in relation to the use cases and research areas in the project (see section “Selection tables”). The selection of the most relevant principles is in relation to use cases from EU partners. International partners were tasked to select the ethical principles in relation to their own use cases, drawing upon either domestic i

We report on the measurement of inclusive, non-prompt, and prompt J/ψ-hadron correlations by the ALICE Collaboration at the CERN Large Hadron Collider in pp collisions at a center-of-mass energy of 13 TeV. The correlations are studied at midrapidity (|y| < 0.9) in the transverse momentum ranges pT< 40 GeV/c for the J/ψ and 0.15 < pT< 10 GeV/c and |η| < 0.9 for the associated hadrons. The measureme

Processes with τ-leptons in the final state are important for Standard Model measurements and searches for physics beyond the Standard Model. The ATLAS experiment at the Large Hadron Collider observes τ-leptons produced in proton–proton collisions only through their decay products. Data analyses involving hadronically decaying τ-leptons face challenges due to backgrounds from jets misidentified as

This doctoral thesis investigates mediaeval earthenware production, distribution and consumption based on material from Lund, Sweden, moving beyond simple technological shifts to explore the interplay of material factors, social practices, and economic influences. It presents a typology of hard greyware, redware and glazed redware, as well as the chemical analysis of circa 400 samples. The study a