Degradation of simethicone – A study on formation of D4, D5 and D6
Simethicone, a widely used anti-foaming agent in pharmaceuticals, consists mainly of polydimethylsiloxane (PDMS) combined with silica gel. While it is safe in pharmaceutical use, concerns have been raised about its degradation into cyclic siloxanes—specifically D4, D5, and D6—which can cause environmental and health hazards. This study investigated the degradation behavior of simethicone under var
