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The evolution of multicellularity is one of the major evolutionary transitions that has shaped the diversity of life on Earth. Multicellular organisms have arisen numerous times across the tree of life, but explaining why some lineages are multicellular while others are unicellular remains puzzling. In my thesis, we tested how the ecological variables may differentially favour multicellular and un
Improving agricultural sustainability is a global challenge, particularly for China's high-input and low-efficiency cropping systems with environmental tradeoffs. Although national strategies have been implemented to achieve Sustainable Development Goals in agriculture, the potential contributions of crop switching as a promising solution under varying future climate change are still under-explore
Stem cells are unique, undifferentiated cells that have the ability to both replicate themselves and develop into specialized cell types. This dual capability makes them valuable in the development of regenerative medicine. Current development in stem cell research has widened their application in cell therapy, drug discovery, reproductive cloning in animals, and cell models for various diseases.
Det socialdemokratiska partiet har byggt upp ett affärspolitiskt komplex vars omfattning är unik i världen. Denna struktur öppnar för politisk korruption, skriver Lars Jonung.Det socialdemokratiska partiet har byggt upp ett affärspolitiskt komplex vars omfattning är unik i världen. Denna struktur öppnar för politisk korruption, skriver Lars Jonung.
This contribution investigates the nexus of legal and economic dimensions in integrating sustainability enhancements into the assessment of anticompetitive agreements under Article 101(3) TFEU, particularly in light of the Commission’s recent Guidelines on Horizontal Cooperation. It is demonstrated that whilst the narrative of market failure at large, and the concept of sustainability failure spec
Polycrystalline cubic boron nitride (PcBN) is renowned for its exceptional hardness and thermal stability, making it ideal for extreme machining conditions. Coatings on PcBN tools further enhance performance by extending tool life and improving cutting efficiency. While uncoated PcBN tools already excel in harsh environments, coatings primarily boost durability. Although extensively studied in tur
The Restricted Syndrome Decoding Problem (RSDP) is a variant of the well-known syndrome decoding problem. It has been recently turned into a post-quantum signature scheme named CROSS by Baldi et al.. It is a scheme highlighted for being computationally friendly and providing a compact signature and public key size. This paper investigates an Oracle-based definition of the RSDP that has already pro
Companies increasingly rely on web-based idea management systems (IMS) to source innovative ideas from their employees and external contributors. While existing research emphasizes the critical role of expert feedback in shaping ideators' subsequent contributions, there remains a limited understanding of how various types of feedback—and their interplay—affect future idea success. Grounded in feed
Several studies have evaluated various ML techniques and found promising results in classifying bug reports. However, these studies have used different evaluation designs, making it difficult to compare their results. Furthermore, they have focused primarily on accuracy and did not consider other potentially relevant factors such as generalizability, explainability, and maintenance cost. These two
Mobile stroke units (MSUs), which are specialized ambulances equipped with a brain imaging device and staffed with trained healthcare personnel, have the potential to provide rapid on-site diagnosis and treatment for stroke patients. However, efficient access to prehospital stroke care requires optimizing the placement of MSUs. The MSU allocation problem has been previously solved using a traditio
The combustion of conventional Jet A, alongside two alternative jet fuels, C1 and C5, is simulated with Large Eddy Simulations (LES) in a generic single-cup spray combustor during idle and cruise conditions. The spray is modeled using Lagrangian particle tracking and the combustion chemistry of each fuel is modeled by skeletal reaction mechanisms. The volatility and atomizability of each fuel dire
A new microphysical treatment that includes aerosol–cloud interactions and secondary ice production (SIP) mechanisms is implemented in the convection scheme of the Community Atmosphere Model, version 6 (CAM6). The approach is to embed a 1D Lagrangian parcel model in the bulk convective plume of the existing deep convection parameterization. Aerosol activation, growth processes including collision/
Background: Combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy significantly improve the outcome of patients with advanced estrogen receptor-positive (ER+) breast cancer. However, resistance to this treatment and disease progression remains a major clinical challenge. High expression of the receptor tyrosine kinase REarranged during Transfection (RET) has been associated with resistance to
