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The predictability of key-value metrics, such as the book-to-market ratio, has declined over the past decade, primarily due to the decreasing reliability of book equity. This trend is particularly evident because traditional value-to-market measures often fail to account for intangible assets. This paper examines the impact of mispricing signals associated with a firm's intangible intensity on the
Introduction: The prevalence of overweight and obesity in children and adolescents continues to rise, and there is a lack of long-term follow-up to clarify health and well-being trajectories into adolescence and adulthood. This study investigated anthropometry and quality of life (QoL) trajectories in 7-14-year-old vulnerable children three years after attending a lifestyle camp. Methods: Vulnerab
Solution-processable quasi-2D perovskites are regarded as promising candidates for laser gain media due to their superior exciton binding energy and stability compared to their 3D counterparts. However, quasi-2D perovskites produced through conventional methods often display a distribution of n-value phases, arising from the necessity of multiple precursors to react. The presence of impurity phase
BACKGROUND: Secondary peritonitis is a severe condition with a 20-32% reported mortality. The accepted treatment modalities are vacuum-assisted closure (VAC) or primary closure with relaparotomy on-demand (ROD). However, no randomised controlled trial has been completed to compare the two methods potential benefits and disadvantages.METHODS: This study will be a randomised controlled multicentre t
INTRODUCTION: Perineal hernia is a protrusion of the pelvic floor containing intra-abdominal viscera. The occurrence of postoperative perineal hernia after abdominoperineal resection (APR) is rare, but reports have indicated a recent increase in occurrence following surgical treatment for rectal cancer. This has been attributed to a shift towards extralevator abdominoperineal resection, together w
AimsThe absence of stent implantation when using drug-coated balloons (DCBs) may decrease the required duration of dual antiplatelet therapy (DAPT). In the light of this, this study aimed to evaluate outcomes for patients with acute coronary syndromes (ACSs) treated with abbreviated vs. standard DAPT after DCB-only percutaneous coronary intervention (PCI).Methods and resultsPatients enrolled in th
Despite the success of antiretroviral therapy, a subset of people with HIV experience low-level viraemia (LLV), a challenging condition with inconsistent definitions and management across settings. We conducted a scoping review of the literature and developed international consensus recommendations through a modified Delphi process involving a multidisciplinary panel of experts. Available evidence
Objectives: To examine the joint effects and mediating role of cardiovascular health (CVH) in the association between social determinants of health and mortality among postmenopausal women. Study design: A nationally representative cohort of 7577 postmenopausal women from NHANES 2003–2018, with mortality follow-up through 2019. Main outcome measures: Social determinants of health were derived from
Background: During the COVID-19 pandemic, visitation restrictions in ICUs intensified psychological distress among family members, yet the long-term impact of psychosocial support on family resilience remains poorly understood. Objective: To evaluate the experiences of family members during the COVID-19 pandemic, focusing on interactions with healthcare professionals and well-being 18th months aft
Bladder cancer is a heterogeneous malignancy with diverse clinical outcomes, and conventional pathological assessment alone is insufficient to capture its underlying biology. Gene expression profiling can stratify tumors into molecular subtypes with prognostic and predictive potential, but the reliability of transcriptomic classification and its clinical utility remains to be established. The tran
Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer’s disease (AD) pathology. However, non-AD-related interindividual variation in biofluids can also affect biomarker concentrations. Here, we investigated whether normalization of CSF and plasma biomarkers to reference proteins, such as amyloid-β40 (Aβ40) and non-phosphorylated mid-re
Objective: Meniscal calcifications are associated with meniscal degeneration and osteoarthritis (OA). We investigated micro-computed tomography (μCT) imaging for identification of calcification patterns caused by basic calcium phosphate (BCP) and calcium pyrophosphate (CPP). Design: Posterior horns of human medial and lateral menisci from 19 individuals with medial compartment knee OA and 21 decea
Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common rheumatic diseases worldwide, causing pain and disability. Both conditions are highly heterogeneous, and their onset occurs insidiously with non-specific symptoms, so they are not always distinguishable from other arthritis during the initial stages. This makes early diagnosis difficult and resource-demanding in clinical env
Background: Expression of CD25, the IL-2 receptor alpha chain, on human mast cells is primarily associated with aberrant mast cells in clonal mast cell disorders. However, the regulation of CD25 expression in normal, mature tissue-resident mast cells remains poorly understood. Objective: IL-33 is a key modulator of immune responses, including in lung inflammatory conditions. Because mast cells are
Abstract Study regionThree mid-high latitude catchments include the Krycklan (Boreal Sweden), the Danube (Central Europe) and the Mississippi (USA).Study focusWe develop a hybrid eco-hydrological framework that couples the process-based terrestrial ecosystem model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) with five machine-learning (ML) algorithms through two hybrid model structure
Mentoring graduate students and postdoctoral researchers shapes the development of future scientists and, by extension, the progress of science itself. Here we explain how scientific mentoring can be enhanced by incorporating history and philosophy of science (HPS). HPS can provide mentees with a vocabulary for interpreting scientific practice and help to foster creative and innovative biologists
OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of therapeutic hypothermia (TH) compared to standard care in newborn infants with hypoxic-ischaemic encephalopathy (HIE).
Preventing obsessive–compulsive disorder (OCD) before it emerges has long been considered a central, yet elusive, goal for researchers. Achieving this will likely require identifying individuals at elevated risk and intervening during critical developmental periods before the onset of impairing symptoms. This trial evaluated the feasibility of a brief parent-guided online targeted prevention progr
This paper critically analyses European Court of Human Rights jurisprudence on bulk data collection, situating it within the Court’s broader turn to proceduralism. We argue that, in cases concerning mass surveillance, the Court has effectively abandoned structured proportionality review and transformed national security from a prima facie legitimate aim into a de facto exception to Article 8. Plac
