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The relationships between polypeptide composition, sequence, structure and function have been puzzling biologists ever since first protein sequences were determined. Here, we study the statistics of occurrence of all possible pentapeptide sequences in known proteins. To compensate for the non-uniform distribution of individual amino acid residues in protein sequences, we investigate separately all
The Intergovernmental Panel on Climate Change (IPCC) has provided periodic assessments of the state of knowledge on climate change for 30 years. While these assessments have been central to the making of international climate policy, their relevance has been questioned in the post-Paris era. Can the IPCC's global kinds of knowledge match the demands of an increasingly decentralized and polycentric
Many individuals with prediabetes, as presently defined, will progress to diabetes (T2D) despite the considerable benefit of lifestyle modification. Therefore, it is paramount to screen individuals at increased risk with a more sensitive method capable of identifying prediabetes at an even earlier time point in the lengthy trajectory to T2D. This petition reviews findings demonstrating that the 1-
Studies have highlighted the existence of two intra-pancreatic axes of communication: one involved in the regulation of enzyme production by insulin—the insular–acinar axis; and another involved in the regulation of insulin release by pancreatic enzymes—the acini–insular axis. Previous studies by our laboratory show that pancreatic enzymes can affect blood glucose homeostasis and insulin secretion
Conceptual design is the first phase in the design process in which all the requirements and design objectives are synthesized into conceptual alternatives. In practice today, major decisions regarding the buildings function, massing, and overall form are usually made during the first phase. Considering structural performance requirements during conceptual design enhances interdisciplinary interac
A key step to the strut-and-tie method is the selection of an appropriate truss model, due to the static indeterminacy of reinforced concrete there are often several suitable models possible. A method for automatically generating a suitable truss model by using graphic statics is presented. Optimal layouts are found by minimizing the total load path. A formulation of constraints suitable for gener
Proteiner är fascinerande makromolekyler som är fundamentala för alla levandeorganismer. De utgör byggstenar i våra celler, ansvarar för transport och signalering både inom och mellan våra celler, utgör en del av vårt immunförsvar och katalyserar bildningen av andra molekyler. Proteiner består av flexibla kedjor uppbyggda av olika aminosyror. Varje aminosyra har olika egenskaper och den specifika Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. At high concentrations proteins are susceptible to self-association, which may lead to amyloid fibril formation – a process linked to many diseases, such as Alzheimer’s disease, Park
Background: This study aims to assess the cost-effectiveness of optimized guideline adherence in patients with a history of coronary heart disease. Methods: An individual-based decision tree model was developed using the SMART risk score tool which estimates the 10-year risk for recurrent vascular events in patients with manifest cardiovascular disease (CVD). Analyses were based on the EUROASPIRE
Background: Ambrosia arborescens has been used in Andean traditional medicine to reduce problems associated with various inflammatory diseases and conditions, although the underlying mechanism is unknown. Hypothesis/purpose: The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary metabolites of A. arborescens, have anti-inflammatory activity by attenuation of IL-6 and MC
A measurement of off-shell Higgs boson production in the ZZ→4ℓ and ZZ→2ℓ2ν decay channels, where ℓ stands for either an electron or a muon, is performed using data from proton–proton collisions at a centre-of-mass energy of s=13 TeV. The data were collected by the ATLAS experiment in 2015 and 2016 at the Large Hadron Collider, and they correspond to an integrated luminosity of 36.1fb−1. An observe
What are core values and what use are they? How can the central governmentcore values translate to academia? Why do the ‘statutory’, political valuesend up in conflict with academic values based on the specific culture ofuniversities? What methods and what examples exist for active and effectivecore values work at a university? And how do you implement core values sothat they are present and meani
PurposeThe aim of this study was to develop and test an instrument to measure surrendering at the time of anesthesia induction and to explore the construct validity.DesignAn instrumental cross-sectional design was used and construct validity was evaluated via psychometric testing.MethodsThe anesthesia surrendering instrument (ASI) comprised 36 items. A total of 202 adults (older than 18 years) ans
