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Molecular oxygen activation at single transition metal atom sites is critical for catalysis but remains challenging to control. Here we investigate a manganese–cobalt bi-metallic coordination network on graphene, where Co(i) atoms are tetracoordinated by nitrogen. Combining density functional theory with in situ infrared-visible sum-frequency generation and ambient-pressure X-ray photoelectron spe
Cryo-scanning electron microscopy (CryoSEM) permits the preparation and detailed imaging of bulky samples while keeping them in a hydrated state. For plant biology, cryofractures give information on cell ultrastructure and tissue organisation within a much larger context that is the whole organ or organism. To date, a method to locate fluorescence reporters on the cryofracture has not been reporte
Construction robot prototype for onsite work. Consists of an ABB IRB4600 mounted on a spindle crane chassi for mobility. Housed in a container for weather protection and logistics.
Om framtiden i Gulfstaterna mörknar efter kriget kommer drömmen sannolikt inte göra det. Den lär flöda vidare – till nästa plats där kapitalet lovar fart, glitter och gränslös framgång. Sofia Ulver undersöker varför svenska ungdomar drömmer sig bort i digitala flöden och utopiska bildvärldar.
Background: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within th
Objective: Degenerative orthopedic diseases (DODs) such as osteoporosis, osteoarthritis, spondylosis, spinal stenosis, and disc herniation are common disorders. Both common and rare genetic risk factors may contribute to DODs, but few large-scale whole-exome sequencing studies elucidating the contribution of rare variations to DODs have been published. The updated version of the Astra Zeneca porta
The molecular mechanisms governing internal fluctuations in intrinsically disordered protein (IDP) assemblies are crucial to the stability and dynamics of both regulated and aberrant toxic cellular aggregates, but remain poorly understood. By comprehensively combining high-resolution quasi-elastic neutron scattering with all-atom molecular dynamics simulations, we probe the motions of β-casein, a
Amyloid-β (Aβ) accumulation is a hallmark of Alzheimer’s disease. Cerebral Aβ deposition is attenuated by a functional glymphatic system, in which perivascular entry of cerebrospinal fluid (CSF) and its exchange with interstitial fluid mediate solute clearance. Parenchymal border macrophages (PBMs), positioned along glymphatic pathways, are emerging as important players for glymphatic clearance. H
Sammanfattning av Kapitel IV:Detta kapitel handlar om att kombinera Pre-kirurgisk strålbehandling och hypertermi (värmebehandling) med fokus på immunologiska effekter. Hypertermi (HT ca 41–44 °C) gör tumörceller mer känsliga för strålning (RT). Kliniska studier visar bättre respons och fler kompletta remissioner med kombinationen RT+HT jämfört med enbart strålning (RT) utan att öka allvarliga biv
