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Background: Type 2 diabetes (T2D) is associated with increased risk of complications after breast cancer surgery. This study investigated systemic and surgical-site postoperative complications and the risk of early and late breast cancer recurrence and mortality, overall, and according to T2D status. Methods: From the Danish Breast Cancer Group (DBCG) and Danish registries, a cohort of women with
Context. The young β Pictoris system has been monitored with high-resolution optical spectrographs for decades. These observations have revealed strongly variable stochastic absorption in the Ca II H&K lines attributed to infalling cometary bodies. Aims. Since 2003, over 9000 HARPS observations of β Pictoris have been taken, and many of these have not yet been used for exocomet studies. We aim
Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster, we present an expanded release of the community-generated population genomics resource Drosophila Evolution over Space and Time (DEST 2.0; https://dest.bio/). This release includes 530 high-quality pooled
In historical the Netherlands, child mortality was distributed unequally between families and this inequality persisted across generations. Using family reconstitution data for the province of Zeeland (LINKS) containing over 200,000 children born 1835–1914, I show that mortality was higher among children under age 5 whose parents lost siblings under age 5. Intergenerational persistence was stronge
Introduction: Wildfires pose escalating risks to communities at the wildland--urban interface, often necessitating extensive evacuations. This thesis explores how driving behaviour during wildfire evacuations differs from routine conditions and how these differences can be modelled to improve traffic simulations, thereby supporting more informed planning and response decisions by authorities.Objec
Background Olfactory dysfunction is a common non-motor symptom in Parkinson’s disease (PD). The objective was to evaluate the association between olfaction in PD with cross-sectional and longitudinal assessments of clinical variables and novel cerebrospinal fluid (CSF) markers. Methods Patients with PD and baseline olfactory function assessed using the Brief Smell Identification Test (B-SIT) were
Cytolysin A (ClyA) is a pore-forming protein from a strongly silenced gene in non-pathogenic Escherichia coli, including typical commensal isolates in the intestinal microbiome of healthy mammalian hosts. Upon overproduction, ClyA-expressing bacteria display a cytolytic phenotype. However, it remains unclear whether sublytic amounts of native ClyA play a role in commensal E. coli-host interactions
Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementia (FTD), exhibit distinct yet overlapping pathological mechanisms. Leveraging large-scale plasma proteomics data from the Global Neurodegeneration Proteomics Consortium, we analyzed 10,527 plasma samples (1,936 AD, 525 PD, 163 FTD, 1,638 dementia and 6,265 controls) to identify di
Given the severe land-use and land-cover change pressure on tropical forests and the high demand for field observations of ecosystem characteristics, it is crucial to collect such data both in pristine tropical forests and in the converted deforested land-cover classes. To gain insight into the ecosystem characteristics of pristine tropical forests (EFs), regrowth forests (RFs), and cashew plantat
Background: A Swedish version of the Patient-Rated Ulnar Nerve Evaluation (PRUNE-S), a patient-reported outcome measure for ulnar nerve entrapment, was created, according to cross-cultural adaptation guidelines, and reliability, validity, and responsiveness were evaluated. Methods: In total, 43 patients (mean [SD] age, 49 [16] y; 54% men) were consecutively examined, including the PRUNE-S (retest:
Amphetamine has widespread effects on multiple neurotransmitter systems, potentially altering the physiological connectivity and network dynamics across various regions of the brain. In this study, we investigated the effects of D-amphetamine using our previously published approach where electrocorticogram (ECoG) recordings from eight cortical areas provided a coarse estimation of the global activ
Combinatorial optimization provides a powerful framework for solving complex optimization problems with general-purpose solvers by modelling the problem in an abstract language. Due to breakthroughs in algorithms to solve combinatorial optimization problems in last decades, combinatorial optimization has become a valid approach to solve many real world problems efficiently. Key application areas a
Vi människor lever genom berättelser, men det är dramat som ställer livet och levandet på sin spets, som får oss att lyssna mer uppmärksamt, minnas viktiga erfarenheter bättre, känna starkare och tänka klarare. Därför dramatiseras nyheter och därför konsumerar vi drama från morgon till kväll på tv, mobil och padda. De flesta av oss har därför rika och varierade erfarenheter av drama och vi har nog
Ultrasound optical tomography combines light and ultrasound measuring optical properties deep inside the body. We experimentally characterize cancer mimicking inclusions in breast tissue phantoms and theoretically simulate imaging performance at significant depths inside the brain.
