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Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previ
OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o
The purpose of this paper is to explore context adaptation of change processes in the setting of public administration. This is done by adopting a contingency approach. Thus, the research question guiding this study is: How is context adaptation enacted in change processes and what are the behavioural implications? Drawing on empirical findings from the Swedish Transport Administration, the study
Supply chain risk management (SCRM) is a common practice for most supply chains. It involves the processes of identifying, assessing, mitigating, and monitoring the risks of providing products and services within the supply chain. Many supply chains have prepared to deal with the uncertainties which may interrupt their supply chain operations. This research is interested to find the current SCRM p
Urban railway systems play an important role in creating sustainable cities, especially in megacities where they serve as the backbone of mass transit. Providing connection information for urban rail systems is essential to ensure continued use of public transport by passengers. However, metro systems can be operated by different service providers, creating challenges in connecting information whi
In its Advisory Opinion on the Legal Consequences arising from the Policies and Practices of Israel in the Occupied Palestinian Territory, including East Jerusalem, the International Court of Justice (ICJ) ruled not only that Israeli policies and practices in the occupied territory systematically violated international law, but also that Israel’s ‘continued presence’ (i.e. occupation) as such had
To evaluate a simplified version of the Clinical Frailty Scale (SCFS) among older adults presenting to the emergency department (ED) with acute dyspnea. In this retrospective single-center cohort study, we included patients from the Acute Dyspnea Study (ADYS) cohort. Severity of illness was assessed using the Medical Emergency Triage and Treatment System (METTS). SCFS was operationalized using exi
Aims: Individuals with type 1 diabetes (T1D) are typically diagnosed at a young age and exposed to lifelong hyperglycaemia. Despite improved metabolic control, the risk of vascular complications remains challenging. However, some individuals remain free from developing major diabetic complications even after long duration, so-called “escapers”. This study investigated transcriptomic biomarkers lin
High nutritional value Andean seeds—tarwi (Lupinus mutabilis), cañihua (Chenopodium pallidicaule), and quinoa (Chenopodium quinoa)—were subjected to solid-state fermentation with Levilactobacillus brevis DSM 1269. This strain can convert L-glutamic acid into the neurotransmitter GABA. Fermented tarwi exhibited the highest GABA production, at 4 mg/g sample, which correlates with its higher protein
Starch microspheres are employed in medicinal products as embolization agents and drug delivery vehicles. For the encapsulation of sensitive ingredients, mild cross-linking techniques are needed, prompting interest in physical cross-linking via starch crystallization. This study investigates starch microsphere formation and crystallization kinetics in aqueous two-phase systems (ATPS) with various
Squamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor-initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis. This study aimed to identify SqCC-specific key regulators that could eventually be used as new anticancer targets. Transcriptional and metabolomic data were gathered
Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41 ± 14 years, height 1.30 ± 0.10 m, body mass 60.5 ± 18.3 kg,
Background: Many traumatic brain injury (TBI) treatment protocols, including the Lund concept, advocate the highest point of the subarachnoid space (typically the vertex) as the zero-reference point for intracranial pressure (ICP) and the level of the right atrium as the zero-reference point for mean arterial blood pressure (MAP). In 2017, at the Department of Neurosurgery in Lund, Sweden, the zer
Parasitoid wasps are major causes of mortality of many species, making host immune defences a common target of adaptive evolution, though such targets outside model species are poorly understood. In this study, we used two tests of positive selection to compare across three closely related Galerucella leaf beetles that show substantial differences in their phenotypic response to the shared parasit
Objective: To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO-2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE-GDM). Design: A cost-analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised controlled trial. Setting: Sweden, with risk-factor based sc
Denna artikel utvecklar ett metodologiskt ramverk för fältbaserad politisk filosofi som integrerar etnografisk undersökning med normativt teoribygge kring socioekonomisk orättvisa. Empiriskt baseras artikeln på kvalitativa intervjuer med individer som är beroende av kontanter i en allt mer digitaliserad ekonomi, en kontext där infrastrukturella reformer missgynnar socialt marginaliserade grupper.TThis article advances a methodological framework for field-based political philosophy that integrates ethnographic inquiry with normative theorising on socioeconomic injustice. Empirically, it draws on qualitative research with individuals reliant on cash in an increasingly digitalised economy, a context in which infrastructural reforms disproportionately disadvantage socially marginalised groups.
