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Despite extensive efforts through various international initiatives to reduce global warming, it has been determined that human induced climate change is here, that the present scale of disruption of the climate is unprecedented and will continue. Increasing weather volatility can be expected, which will most likely increase exposure to weather related hazards, e.g. wildfires, flooding. The aim ofDespite extensive efforts through various international initiatives to reduce global warming, it has been determined that human induced climate change is here, that the present scale of disruption of the climate is unprecedented and will continue. Increasing weather volatility can be expected, which will most likely increase exposure to weather related hazards, e.g. wildfires, flooding. The aim of

BACKGROUND: The NextFood Project ( www.nextfood-project.eu) started work in 2018 to identify 'Categories of Skills' that students should be equipped with to address the upcoming global challenges within agrifood and forestry disciplines, and involved concepts such as sustainability, technological adaptation and networking. This study is based on the initial skills and competencies mapping, but tak

In post-peace agreement Colombia, everyone declared war on the forest. In the Putumayo region, these wars take their own particular forms. Scientifically, the Putumayo is described as an Andean-Amazonic rainforest. For the indigenous and local inhabitants of the Putumayo, it is the Andean-Amazonic selva. We present three wars on the forest with material and discursive specificities and critically

Adult neurogenesis continues throughout life but declines dramatically with age and in neurodegenerative disorders such as Alzheimer's disease. In parallel, microglia become activated resulting in chronic inflammation in the aged brain. A unique type of microglia, suggested to support neurogenesis, exists in the subventricular zone (SVZ), but little is known how they are affected by aging. We anal

Diabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial, mesangial and proximal tubular cells) in insulin sensitive and resistant conditions, and perform simultaneous transcriptomics and proteomics for integrated a

Osteosarcoma treatment comprises pre-surgical chemotherapy followed by radical surgery and further chemotherapy cycles, but the prognosis has been far from satisfactory. No new drugs or treatment modalities have been developed for clinical use in the last four decades. We describe a nano-hydroxyapatite (HA)-based local drug delivery platform for the delivery of doxorubicin (DOX), a cornerstone dru

Objectives: Subarachnoid haemorrhage (SAH) carries a high burden of morbidity and mortality. One in three patients develop vasospasm, which is associated with Delayed Cerebral Ischemia. The pathophysiology includes vasoconstrictor receptor upregulation in cerebral arteries. The protein kinase C – inhibitor RO-31-7549 reduces the expression of several vasoconstrictor receptors and normalizes cerebr

Fibroblasts are adherent cells that maintain tissue homeostasis by sensing and responding to the extracellular matrix (ECM). Focal adhesions (FAs) link these ECM changes to actomyosin dynamics through changes in its composition, influencing cellular response. Septin-7 (Sept-7) has previously been found in FA proteomics studies and shown to influence ECM sensing. Using total internal reflection mic