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Background and purpose: Synthetic computed tomography (sCT) enables magnetic resonance imaging (MRI)-only radiotherapy by providing electron density information for dose calculation. While sCT-based planning has been proven sufficiently accurate for convolution-based dose calculation algorithms, linear Boltzmann transport equation (LBTE)-based approaches exhibit higher sensitivity to tissue hetero
To describe the impact of adding a tyrosine kinase inhibitor (TKI) to intensive chemotherapy (IC) on the outcome of de novo BCR::ABL1+ acute myeloid leukemia (AML), we retrospectively analyzed the data of 212 adult AML with ≥20% bone marrow blasts, BCR::ABL1+ or t(9;22)(q34.1;q11.2), no history of previous chronic myeloid leukemia and no prior exposure to BCR-ABL1 TKI. Eighty-nine patients were tr
Blood-based biomarkers are emerging as scalable tools for the diagnosis and monitoring of neurodegenerative diseases, but markers enabling differential diagnosis across major dementias remain limited. Here we show that large-scale plasma proteomics identifies disease-associated signatures across Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia. We analyzed 1,318 plasma sa
Ultrasound-induced degradation of soft polymeric colloids, like microgels, as well as a controlled drug release enabled by mechanoresponsive bonds, has recently attracted considerable attention. However, most examples in the literature focus primarily on the applications rather than examining the underlying mechanisms of the structural changes occurring in microgels due to cavitation─changes that
We propose a network behavioral-feedback Susceptible–Infected–Recovered (SIR) epidemic model in which the interaction matrix describing the infection rates across subpopulations depends in feedback on the current epidemic state. This model captures both heterogeneities in individuals’ mixing, contact frequency, aptitude to contract and spread the infection, and endogenous behavioral responses such
Dwarf spheroidal galaxies are often conjectured to be the sites of the first stars. The best current contenders for finding the chemical imprints from the enrichment by those massive objects are the "ultrafaint dwarfs" (UFDs). Here we present evidence for remarkably low heavy element abundances in the metal poor Hercules UFD. Combined with other peculiar abundance patterns this indicates that Herc
Food industry plays major role in public health, economic and environmental sustainability. Integration of machine learning (ML) is increasingly reshaping elements like safety protocols, quality management and supply chain optimization, though outcomes vary substantially by context and scale. This paper comprehensively synthesizes the ML applications by employing a systematic literature review (SL
Background: Iron deficiency is a common and clinically relevant comorbidity in heart failure, associated with reduced functional capacity, higher symptom burden, and increased hospitalisation risk. Most evidence on iron deficiency in heart failure originates from hospital-based cohorts, whereas the epidemiology and clinical implications in primary care populations remain poorly described. This stu
BACKGROUND AND PURPOSE: The glymphatic system facilitates perivascular clearance, and its dysfunction has been implicated in neurodegenerative diseases. Diffusion tensor imaging along the perivascular space (DTI-ALPS) has been proposed as an indirect approach to assess glymphatic function, but its reliability is debated. The choice of b-value is an aspect of possible improvement. While a b-value o
Introduction: The structures of the skull and the brain are related to each other. Prior work in individuals with isolated congenital anosmia (ICA) showed that these individuals were characterized by olfactory bulb (OB) defects. The aim of this study was to compare the morphological pattern of the anterior skull base surrounding the OB between individuals with ICA and normosmic controls. We meant
Time-resolved X-ray solution scattering (TR-XSS) provides direct access to protein structural dynamics but has largely been restricted from the microsecond range up to approximately 100 milliseconds. As a result, slower enzymatic systems, including many P-type ATPases, remain difficult to probe. Here, we extend the temporal reach of TR-XSS by sequentially positioning radiation damage-free acquisit
Debatt: Att personer frihetsberövas under decennier i den rättspsykiatriska vården på oklara grunder är helt oacceptabelt i en rättsstat. Det skriver Tova Bennet, lektor i straffrätt.
In real-world design practice, evaluations rarely rely on a single source of judgment. Designers routinely combine expert opinions, empirical studies, and computational models, each with distinct strengths and limitations. While machine learning offers methods to integrate multiple feedback sources, these approaches remain largely inaccessible to designers without technical expertise. In this pape
PURPOSE: We explored the associations between vitamin C intake and the risk of islet autoimmunity (IA) and/or type 1 diabetes in genetically at-risk children. Furthermore, we explored associations between vitamin C metabolism-related single nucleotide polymorphisms (SNPs) and type 1 diabetes outcomes.METHODS: The current study within Environmental Determinants of Diabetes in the Young (TEDDY) coho
Debatt: Det svenska rättssystemet som tillåter att vi dömer psykiskt sjuka för brott och att personer som saknar vårdbehov kan hållas frihetsberövade inom rättspsykiatrin under mycket lång tid med oklart vårdinnehåll, är unikt och har fått rättmätig kritik under lång tid. Ändå händer ingenting. Det är oförsvarbart, skriver bland andra Tova Bennet, doktor i straffrätt, Lunds universitet.
