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City densification offers several sustainability benefits. However, in areas near railways, concrete buildings can be preferred over timber buildings, despite timber being a more environmentally friendly option. This preference is primarily due to concerns about vibrations affecting timber buildings, which has limited their adoption. This paper investigates dynamic substructuring for analyzing tim
BACKGROUND: Weight bias and stigma have transformed body weight from a purely biological attribute into a complex social phenomenon. Social and health scientists continue to critically examine how weight stigmatising discourses and biased perceptions shape attitudes, beliefs and everyday experiences. Studies show that socially mediated subjectivities profoundly affect women's health-related behavi
Females who have larger bodies or obesity may be at an increased risk for experiencing infertility. Problematically, both weight or body size and infertility are stigmatized, harming quality of care. We conducted a scoping review to understand the lived experiences of patients who may be subjected to intersecting stigmas of weight and infertility in healthcare. Searches included six databases (Med
Climate change represents a major threat to global biodiversity and associated ecosystem functions, including pollination. In both natural and agricultural environments, semi-natural grasslands represent crucial foraging and nesting habitats for wild pollinators such as bumblebees, for which temporal population trends in these habitats remain understudied. Here, we use data from a large-scale syst
Background – Trastuzumab deruxtecan (T-DXd) is effective in HER2-expressing metastatic breast cancer (mBC), yet inter-patient benefit varies. The current reference biomarker—HER2 immunohistochemistry (IHC) on tumor biopsies—is insufficient as a sole predictor of response. HER2-targeted PET/CT offers non-invasive, whole-body, real-time assessment of target expression. We hypothesize that HER2-targe
The use of ground-source heat pump systems for heating and cooling of buildings is becoming increasingly widespread throughout the world. The most common application of ground-source heating and cooling systems uses vertical boreholes. The primary function of a ground heat exchanger is to efficiently transfer heat between the ground and an above-ground heating and/or cooling load. The heat transfe
Twenty-five years ago, the book The Ecology of Adaptive Radiation by Dolph Schluter presented a testable framework that integrated ecology, genetics, and natural history to explain the mechanisms driving adaptive radiation, the rapid diversification of a single lineage into multiple species occupying distinct ecological niches. One important contribution was to re-orientate the study of adaptive r
The purpose of this study was to contribute to the development of a model including parameters for matching health-care services to patients. Inspired by ‘engaged scholarship’, the researchers practised continuous and close collaboration with practitioners at Region Skane in Sweden. The agenda was based on questions and experiences that evolved from theory and experience gained during previous res
Parkinson’s disease (PD) is a neurodegenerative disorder characterized byprogressive loss of dopaminergic (DA) neurons in the substantia nigra parscompacta (SNpc) of the midbrain. Loss of dopaminergic signalling leads to rigidity,resting tremor, and difficulties controlling voluntary movements, contributing to asignificantly reduced quality of life for the patient. Alpha-synuclein (α-syn) is a pre
Pedal acceleration time (PAT) has recently attracted clinical interest for assessing peripheral arterial disease (PAD), particularly in patients in whom ankle–brachial index (ABI) or toe pressure measurements are unreliable or not feasible, yet its diagnostic worth has not been systematically evaluated. We searched MEDLINE, Embase, ScienceDirect, and the Cochrane Library from inception to January
Hairy cell leukemia (HCL) and HCL variant (HCLv) are distinct, rare, and chronic splenic B-cell lymphomas/leukemias that partially overlap in clinicopathologic presentation but differ in genetic basis, prognosis, and management. HCL is caused by the BRAF-V600E kinase–activating mutation in >95% of the patients, usually has excellent responses to chemotherapy with purine analogues, and is also amen
