Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-related death. Research over the years has postulated various experimental models that have facilitated an understanding of the complex mechanisms underlying WNT si

Among different lipid nanoparticle systems, sponge-phase nanoparticles (SPNPs) have recently attracted interest due to their ability to encapsulate large macromolecules along with demonstrated high interfacial activity. The potential application of SPNPs calls for investigations into how buffer conditions affect SPNP structure and interfacial activity. Herein, we systematically investigated how di

Interpretation of data from faint dwarf galaxies is made challenging by observations limited to only the brightest stars. We present a major improvement to tackle this challenge by undertaking zoomed cosmological simulations that resolve the evolution of all individual stars more massive than 0.5 M⊙, thereby explicitly tracking all observable stars for the Hubble time. For the first time, we predi

Background: Community-acquired pneumonia (CAP) was one of the most common causes of death in the European Union in 2017. Severity and mortality of CAP increase with age and an aging European population will require increased planning for prevention, control, and management of CAP. The purpose of this study was to provide an updated population-based estimate of the incidence of CAP requiring hospit

Background: Adverse pregnancy outcomes, such as preterm delivery and hypertensive disorders of pregnancy, may be associated with higher future risks of heart failure (HF). However, the comparative effects of different adverse pregnancy outcomes on long-term risk of HF, and their potential causality, are unclear. OBJECTIVES: The authors sought to examine 5 major adverse pregnancy outcomes in relati

Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders. Methods We identified 6 049 717 individuals born in Sweden between 1950 and 20

Background: The aging of the world’s population and the increase in sedentary lifestyles are leading to an increase in walking impairments at older ages. Here, we aimed to comprehensively discuss walking in the context of an aging population; and identify and agree on a list of future research priorities and policy actions. Methods: We followed a participatory approach and held a multidisciplinary

Policy institutes such as central banks need accurate forecasts of key measures of economic activity to design stabilization policies that reduce the severity of economic fluctuations. Therefore, this paper develops a kernel ridge regression estimator in a mixed data sampling framework. Kernel ridge regression can handle many predictors with a nonlinear relationship to the target variable. Consequ

A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.

In dialogical self theory (DST) authenticity has not been a central concern. The humanist notion of a static, higher-order, superordinate, ultimate, and “true” self runs counter to the ontology of DST, and the conceptualization of the dialogical self as unconsolidated, multifaceted, dynamic, and sensitive to situational change. In a climate in which the psychology of authenticity is undergoing rev

We investigate experimentally the quantum coherence of an electronic two-level system in a double quantum dot under continuous charge detection. The charge state of the two-level system is monitored by a capacitively coupled single quantum dot detector that imposes a backaction effect on the system. The measured backaction is well described by an additional decoherence rate, approximately linearly

En stad är aldrig färdig, genom byggda förändringar och omförhandlade relationer. Samtidigt är en stad alltid färdig genom nuet hos dem som bor i den. Detta projekt syftar till att undersöka denna paradox och hur medvetenheten om tid och förändring kan berika design. Det studerade området för projektet är Varvsstaden i Malmö. En plats som en gång i tiden var en del av ett av världens största skeA city is always in the process of becoming, through built changes and renegotiated relationships. At the same time, a city is always finished through the present of those who live in it. This project aims to investigate this paradox and how the awareness of time and change can enrich design. The studied area of the project is Varvsstaden in Malmö. A place which was once a part of one of the lar

Forests play a crucial role in mitigating climate change by sequestering 29% of anthropogenic emissions. However, their sink capacity is highly sensitive to climate-induced disturbances, such as weather extremes, which can cause significant interannual variations in Net Ecosystem Exchange (NEE). With environmental stressors likely to become more frequent, understanding the drivers behind carbon ex

Cytostatika är läkemedel som används för att behandla cancer genom att hämma eller stoppa celldelning. De används även som immunhämmande medel, till exempel vid organtransplantationer och autoimmuna sjukdomar. Eftersom dessa läkemedel påverkar cellers tillväxt kan de vara skadliga även i mycket små mängder om de hamnar i miljön. Cytostatika har upptäckts i ytvatten, grundvatten och dricksvatten i Introduction: Cytostatic pharmaceuticals are increasingly detected in the aquatic environment, raising concerns due to their persistence and toxicity. Background: Conventional wastewater treatment processes do not effectively remove these compounds. Advanced oxidation processes, such as ozonation, are needed to degrade cytostatic pharmaceuticals during wastewater treatment. However, these process

Syftet med denna uppsats har varit att undersöka om progressiva konstruktioner har blivit vanligare i svenskan. Bakgrunden till frågeställningen var en misstanke om att konstruktionen håller på och + V har blivit vanligare. Den första forskningsfrågan var: Har konstruktionen håller på och + V blivit vanligare på bekostnad av konstruktionen håller på att + V? Den andra forskningsfrågan var: Har kon

The pulmonary route has emerged as a promising strategy for delivering protein therapeutics, particularly for patients suffering from respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary infections. This project investigated the effect of operating parameters of a laboratory spray dryer on the characteristics of powders composed of Bovine Serum Albumin