Electrons photoemitted by extreme ultraviolet attosecond pulses derive spatially from the first few atomic surface layers and energetically from the valence band and highest atomic orbitals. As a result, it is possible to probe the emission dynamics from a narrow 2D region in the presence of optical fields, as well as obtain elemental specific information. However, combining this with spatially-re

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are increasingly used in patients with type 2 diabetes, chronic kidney disease, and heart failure. However, their safety and efficacy in patients with congenital or surgically altered urogenital anatomy remains underexplored. Methods: We conducted a narrative review of current evidence regarding the use of SGLT2i in patients with urina

Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations in biological samples, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are limited. We report a polarized dual-view light-sheet system for determining the diffraction-limited three-dimensional distribution of the orientations and positions of ensembles of fl

Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i

Kollektivtrafiken är en viktig del av transportsektorn för att uppnå både EU:s och Sveriges klimatmål. För att fler resor ska kunna ersättas med hållbara resor behöver kollektivtrafiken bli mer attraktiv, och ett utvecklingsområde för det är att förbättra trafikinformationen. Trafikinformation värderas högt, inte bara utifrån dess tillgänglighet, utan även utifrån kvaliteten. Den påverkar både denPublic transport is an important part of the transport sector in achieving both the EU’s and Sweden’s climate goals. In order to replace more journeys with sustainable alternatives, public transport needs to become more attractive, and one area for development is the improvement of traffic information. Traffic information is highly valued, not only in terms of its availability, but also in terms o

Bakgrund: Menstruation är en naturlig fysiologisk process och miljontals flickor menstruerar varje dag. Trots detta påverkas den menstruella hälsan av mensfattigdom vilket är mer vanligt i en fattig kontext, där bland annat kulturella seder riter och tabun får en stor inverkan, ofta på grund av brist på information och rätt kunskap. Mensfattigdom är ett samlingsbegrepp som grundar sig i bristen på

Cykeln är ett enkelt och effektivt transportsätt med flera trafiktekniska, miljömässiga och sociala fördelar. Trots det kan cykelinfrastrukturen i många fall vara eftersatt och bortprioriterad. De flesta dödsolyckor i cykeltrafiken sker vid kollision med motorfordon vilket gör interaktionen med motorfordon intressant. Främst kan cykelinfrastruktur i korsningar utformas integrerat där cyklister förThe bicycle is an efficient mode of transport that is often deprioritized. The intersection, where many casualties occur, can be designed either integrated or separated. The aim of this thesis is to investigate the safety effects of these designs, the motives behind them and to decide if the distinction between them is relevant by doing a literature review as well as an interview review. It is har

Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-related death. Research over the years has postulated various experimental models that have facilitated an understanding of the complex mechanisms underlying WNT si

Among different lipid nanoparticle systems, sponge-phase nanoparticles (SPNPs) have recently attracted interest due to their ability to encapsulate large macromolecules along with demonstrated high interfacial activity. The potential application of SPNPs calls for investigations into how buffer conditions affect SPNP structure and interfacial activity. Herein, we systematically investigated how di

Interpretation of data from faint dwarf galaxies is made challenging by observations limited to only the brightest stars. We present a major improvement to tackle this challenge by undertaking zoomed cosmological simulations that resolve the evolution of all individual stars more massive than 0.5 M⊙, thereby explicitly tracking all observable stars for the Hubble time. For the first time, we predi

Background: Community-acquired pneumonia (CAP) was one of the most common causes of death in the European Union in 2017. Severity and mortality of CAP increase with age and an aging European population will require increased planning for prevention, control, and management of CAP. The purpose of this study was to provide an updated population-based estimate of the incidence of CAP requiring hospit

Background: Adverse pregnancy outcomes, such as preterm delivery and hypertensive disorders of pregnancy, may be associated with higher future risks of heart failure (HF). However, the comparative effects of different adverse pregnancy outcomes on long-term risk of HF, and their potential causality, are unclear. OBJECTIVES: The authors sought to examine 5 major adverse pregnancy outcomes in relati

Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders. Methods We identified 6 049 717 individuals born in Sweden between 1950 and 20

Background: The aging of the world’s population and the increase in sedentary lifestyles are leading to an increase in walking impairments at older ages. Here, we aimed to comprehensively discuss walking in the context of an aging population; and identify and agree on a list of future research priorities and policy actions. Methods: We followed a participatory approach and held a multidisciplinary

Policy institutes such as central banks need accurate forecasts of key measures of economic activity to design stabilization policies that reduce the severity of economic fluctuations. Therefore, this paper develops a kernel ridge regression estimator in a mixed data sampling framework. Kernel ridge regression can handle many predictors with a nonlinear relationship to the target variable. Consequ

A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.