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Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functional variants to confirm

In this paper we study structure from motion problems for parallel cylinders. Using sparse keypoint correspondences is an efficient (and standard) way to solve the structure from motion problem. However, point features are sometimes unavailable and they can be unstable over time and viewing conditions. Instead, we propose a framework based on silhouettes of quadric surfaces, with special emphasis In this paper we study structure from motion problems for parallel cylinders. Using sparse keypoint correspondences is an efficient (and standard) way to solve the structure from motion problem. However, point features are sometimes unavailable and they can be unstable over time and viewing conditions. Instead, we propose a framework based on silhouettes of quadric surfaces, with special emphasis

A multi-authored roadmap paper on deep learning in microscopy. Our contribution a section on deep learning in microscopy of plankton

Asthma is a chronic inflammatory lung disease affecting over 300 million individuals worldwide. Both respiratory viral infections and aeroallergens have been identified as important risk factors for asthma. Rhinovirus (RV) infection has been recognized as a major cause of asthma exacerbations, and current research indicates that RV and allergens may have a synergistic effect, resulting in a higher

Urban freight logistics is a growing phenomenon in cities and contributes to the wealth of citizens and businesses in urban areas. But it also has negative side effects such as emissions, congestion, and accidents, which eradicate some of their benefits for society. The current development of urban freight logistic activities is unsustainable. A more sustainable path of development is needed but i

Saliva plays a crucial role in maintaining oral health through its physical and chemical properties that provide various protective functions. One of its essential components is the human host defense peptide LL-37, which is produced by immune cells and epithelial cells, and participates in the first line of defense against pathogens. LL-37 is a potent antimicrobial agent against both gram-positiv

Under de senaste åren har det skett en förskjutning i forskningen från att försöka förstå vem som löper risk att bli radikaliserad, till att undersöka vad som gör att vissa individer har större benägenhet att bli radikaliserad. Känslor av exkludering, diskriminering och marginalisering har tidigare kopplats till extremistiska handlingar. Trots det finns det få empiriska studier som utforskar sambaThe present thesis aims to examine the causal role of social exclusion within theradicalization process and further to explore moderating and mediating factors. In recent years there has been a move away from trying to understand who is at risk of becoming an extremist, to exploring what makes someone at risk. Feelings of exclusion, discrimination and marginalization have all been linked to partic

The intestinal lamina propria contains a diverse network of fibroblasts that provide key support functions to cells within their local environment. Despite this, our understanding of the diversity, location and ontogeny of fibroblasts within and along the length of the intestine remains incomplete. Here we show that the small and large intestinal lamina propria contain similar fibroblast subsets t

This book discusses the importance of developing routininized behaviours in new venture development, specifically highlighting the unique challenges that academic spin-offs face in this vital step towards successful business creation. During the early development stage, new ventures are informally established and have few routines that inform organizational performance. However, the process of new

This gait biomechanics study investigated stride length (SL), stride duration (SDN), the peak values of ground reaction forces (GRFspeak), required coefficient of friction (RCOFpeak), leg joints’ angles (anglepeak), angular velocity (angvelx.peak), angular acceleration (angaccx.peak), minimum angle (anglemin.) of the foot, and muscles’ electromyography (EMG) during the stance phase (SP) of the dom

While personal data is invaluable to firms, the drivers of e-commerce customers' willingness to disclose their personal data remain tenuous. Using social exchange theory, we develop a model that explores the impact of consumers' perceived benefit, and relative power, on store trust, in turn driving their willingness to disclose their personal data. We collected our empirical data using a represent

A viewpoint about the importance of ethnicity in medical research.

IntroductionMild parkinsonian signs (MPS) have been characterized by several definitions, using the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS). We aimed to investigate the prevalence of MPS and their association with functional level and comorbidities in the oldest old.MethodCommunity-dwelling older adults (n = 559, median age 85, range 80–102 years) were examined regarding

Purpose: To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques.Methods: Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for

PurposeMyelin water imaging (MWI) using multi-echo T2 relaxation is a quantitative MRI technique that can be used as an in vivo biomarker for myelin in the central nervous system. MWI using a multi-echo spin echo sequence currently takes more than 20 min to acquire eight axial slices (5 mm thickness) in the cervical spinal cord, making spinal cord MWI impractical for implementation in clinical stu

Technological developments now make it possible to employ many markers for many individuals in a phylogeographic setting, even for taxa with large and complex genomes such as salamanders. The banded newt (genus Ommatotriton) from the Near East has been proposed to contain three species (O. nesterovi, O. ophryticus and O. vittatus) with unclear phylogenetic relationships, apparently limited intersp

Speciation entails a reduction in gene flow between lineages. The rates at which genomic regions become isolated varies across space and time. Barrier markers are linked to putative genes involved in (processes of) reproductive isolation, and, when observed over two transects, indicate species-wide processes. In contrast, transect-specific putative barrier markers suggest local processes. We studi

Theoretical and empirical studies suggest that the structure and position of hybrid zones can change over time. Evidence for moving hybrid zones has been directly inferred by repeated sampling over time, or indirectly through the detection of genetic footprints left by the receding species and the resulting asymmetric patterns of introgression across markers. We here investigate a hybrid zone form