The human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that is involved in many cellular pathways. The HER2 locus is amplified in 12-21% of all breast cancers and is associated with poor prognosis. The introns of HER2 contain two non-coding RNAs: a microRNA (miRNA) named mir-4728 and a box C/D snoRNA-like molecule thus far named snoID_0714. In this study, a list of targe

Office space is a vital element of every organization. Additionally, there is an ongoing debate on how to utilize office space most effective to maximize occupancy while providing an efficient work environment for employees. Because office space is the daily work environment for many people, in which they spend a tremendous amount of their time, office space can exert a considerable impact on thei

The regional disparities in China are increasing, at the same time as the growth moderates. In order to keep successful development in the future, China is rapidly developing the rail infrastructure, as one of the main channels to obtain a balanced regional development. The argument is that regional inequalities will decrease through increased economic interconnection and mobility provided by the

The study of high-quality genomic sequences from great-apes, our closest relatives and one of the most relevant to understand human bio-logical processes, is reaching a limit in terms of access. New methods are needed to achieve the maximum variant information from lower-quality samples. In that scenario, imputation is shown as a good candidate for improving genotype information on low-genotyped d

The purpose of this to study is to identify factors that influence how a concept store format contributes to a format portfolio, which will be done by exploring the concept store format from three perspectives; customers, manager, and industry experts. Philosophies of epistemology and ontology were considered, where the social constructionism stance was employed. Additionally, the research followe

With the aim of widening the picture of a Late Iron Age warrior society in central Blekinge by studying the social role of its women, female cremation burials have been identified and their material studied. Artefacts and their combinations have been interpreted and their suggested meanings compared with contemporary iconography as well as with Anglo-Saxon and Norse literary sources. The grave mat

Atherosclerosis, a chronic inflammatory condition, is the main attributor to cardiovascular disease. As such, elucidating the underlying immunological events that occur during atherogenesis has become an area of interest to better understand atherosclerotic pathology. T cells are an integral component of the adaptive immune response and have been shown to be present in atherosclerotic plaques. How

This study investigates and compares the value added by merger and acquisition activity within the airline industries of the United States of America and Europe following the deregulation of each respective market. An abnormal return event study methodology was performed with three different event window lengths using a final sample of 64 public airline mergers. The focus of the study was on abnor

I diskussionen om den motbjudande slutsatsen har vissa filosofer försökt försvara utilitarismen genom att ifrågasätta tillförlitligheten hos våra intuitioner. Två typer av dessa försvar går att urskilja. Enligt det första är vår intuition inte tillförlitlig därför att vi har fel uppfattning om vad det innebär att leva ett liv knappt värt att leva. Enligt det andra är vår intuition inte tillförlitlIn this essay I consider whether it is possible to defend Utilitarianism against The Repugnant Conclusion by questioning the reliability of our intuitions about large number cases. The first part deals with a proposal by John Broome. Broome claims that our “homely intuitions” should be set aside in large number cases, just as our intuitions for building bridges should be set aside when spanning br

Syftet med studien är att undersöka hur väl svenska börsnoterade fastighetsbolag efterlever de upplysningskrav som anges i IAS 40 punkt 75 och 76. Vidare undersöks om det föreligger några skillnader mellan olika år (2010, 2018), samt om det finns samband mellan upplysningsgrad och tre på förhand utvalda företagsegenskaper. Studien jämför efterlevnad av IAS 40 punkt 75 och 76 hos 15 svenska slumpmä

The purpose of this study is to examine incentive-based pay to CEO’s at publicly listed companies and how this is affected by the demographic variables of gender and age. Furthermore, profitability will be taken into account in order to examine the connection with incentive-based pay.We find a positive and statistically significant correlation between the CEO’s share of variable remuneration and his or her age, as well as between share of variable remuneration and profitability. However, we do not find any significant correlation between variable remuneration and gender.

The aim of this bachelor thesis is to examine consumers’ perceived symbolic value of H&M’s designer collaborations and if they consider the concept as a democratization of fashion. These collaborations are a part of a bigger and more complex development of the fashion industry. Therefore, the analysis begins with a literature study which discusses the alleged democratization of fashion. Therea

Notice taken towards the position of philanthropy in sub-Saharan Africa has increased in the lastdecade. Increasing amounts of private wealth, charity and philanthropy initiatives are changing the landscape earlier characterised by traditional forms of philanthropy that have been practised between people and communities. This study explored the central conversation around philanthropy in sub-Sahar

This thesis focuses on the integration of management control system (MCS) and sustainability in companies. Some literatures showed a disconnection between the efficiency of sustainability as a success strategy and management control systems. To research this, we aim at answer two questions. What are the challenges that the companies were faced with when they tried to integrate MCS and sustainabili

Riskanalys för Hurvas dricksvattentäkt I den lilla byn Hurva i Skåne tar man sitt dricksvatten från berggrunden. Hurva omges av jordbruksmark och har en aktiv bilskrot. Dessutom går E22:an förbi i utkanten av byn. Om ett utsläpp sker skulle det kunna skada grundvattnet. Denna riskanalys gjordes tillsammans med VA SYD, som har ansvar för dricksvattnet I Hurva. De har även hand om dagvatten (regn-Groundwater is one of our most important natural resources. Therefore, it is important to monitor the groundwater and to protect it from pollution. At Hurva, southern Sweden, the local drinking water is produced by groundwater extraction. In this study the potential impact of storm water on groundwater quality at Hurva is studied in a risk analysis. Mapping of the geology and hydrogeology in the

Påverkar antalet patogener variationen hos immungener? Hur många olika patogener (sjukdomsframkallande organismer) ens immunsystem kan bekämpa beror delvis på hur hög s.k. MHC-diversitet man har (MHC = Major Histocompatibility Complex). Populationer med hög patogenbelastning förväntas ha en högre MHC-diversitet än populationer med lägre patogenbelastning. Klimat-förändringarna förväntas leda tilThe major histocompatibility complex (MHC) is important for adaptive immunity where the MHC molecules bind and present peptides from pathogens to T cells. The peptide binding repertoire of an individual’s MHC molecules determines what pathogens can be recognised by the immune system, and the MHC peptide binding repertoire is therefore under strong selection from pathogens. Parasite and pathogen di

Background: In today’s changing retail landscape, traditional business models are becoming rapidly outdated, signalling the end of traditional retail. Shopping centre owners need to remain agile and willing to re-evaluate their business models, as emerging technologies and changing consumer behaviours are reshaping the retail industry. Only those who have taken notice of these changes and challeng

Det okända UFO-proteinet kan vara involverat i drogresistens Leukemi är en cancerform som påverkar benmärgen och blodet. Benmärgen producerar stamceller som i sin tur utvecklas till blastceller, även känt som blodceller i tidigt utvecklingsstadium. Dessa blastceller har en avvikande utvecklingsprocess och blir aldrig fullt utvecklade blodceller. Det finns fyra undergrupper av leukemi baserat på