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The energetics and dynamics of ion assembly in solution has broad influence in nanomaterials and inorganic synthesis. To investigate the fundamental processes involved, we present a time-resolved x-ray solution scattering (TR-XSS) study of the trinuclear silver and thallium complexes of the diplatinum ion PtPOP [Pt2(H2P2O5) 4 4 − ] in aqueous solution. These complexes, their structural properties,

Background Breast cancer patients undergoing mastectomy are not well represented in studies evaluating the omission of completion axillary lymph node dissection (cALND) due to sentinel lymph node (SLN) metastases. Methods The prospective multicentre SENOMIC cohort trial included patients with breast cancer and SLN micrometastases between October 2013 and December 2022. Completion ALND was omitted

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Objectives: Current therapeutic strategies for essential thrombocythemia (ET) are mainly considered to prevent thrombo-hemorrhagic events, without increasing the rate of fibrotic progression or leukemic evolution. To treat the patients appropriately, the precise diagnosis of ET is essential. Although approximately 30% of ET cases are diagnosed as CALR mutation-positive; commercially available poly

The surface chemistry of mesoporous nickel oxide (NiOx) plays a pivotal role in its functionality across various technological applications. Herein, we present a detailed study of NiOx surface states using multiple spectroscopic techniques, including ambient pressure X-ray photoelectron spectroscopy (XPS), ultraviolet-visible (UV-vis) spectroscopy, and Fourier-transform infrared (FTIR) spectroscop

The last mute film in Carl Th. Dreyer’s oeuvre, The Passion of Joan of Arc (1928), is often referred to as a film “made of close-ups” and purely cinematic. Dreyer used to stress himself that close-up was the specific cinematic device that asserted film’s position as autonomous art. He especially insisted on film’s independence from theatre. Thus, it might sound quite surprising that in an intervi

Industrial sector, by boosting energy efficiency and reducing waste through the use of digital twin (DT) technology in the integration of industrial IoT (IIoT). DT generates realistic simulations for predictive analytics and decision-making with the help of real-time simulations of physical objects. In this chapter, the authors focus on the DT application for the optimum utilization of energy and

Adaptive haptics, an amalgamation of different haptic systems and machine learning algorithms, has the potential for intelligent feedback in healthcare. Such systems are capable of learning to suit individual user needs in real-time, thereby improving patient care, medical education, and treatment. Targeted techniques of machine learning approaches are reinforcement learning, neural networks, supp

Self-compassion is associated with positive mental health outcomes and may buffer against negative self-evaluations and emotional difficulties. Nevertheless, studies among athletes often explore self-compassion in specific groups in isolation (e.g., women athletes) (Röthlin et al., 2019). The aims of this study were to 1) explore whether the relationship between gender and composite scores and spe

INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) w

Although leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, has been approved based on short-term clinical trials conducted in Japan, its long-term efficacy on physical function remains unclear. We aimed to evaluate the long-term therapeutic efficacy of leuprorelin acetate using real-world clinical data through a self-controlled trend-shift analysis. The analysis included 91 gen

A hybrid assistive limb (HAL) can improve the motor performance of patients with various neurodegenerative diseases, but the efficacy of home-based rehabilitation using HAL for spinocerebellar ataxias (SCA) has yet to be elucidated. To evaluate the efficacy and safety of home-based telerehabilitation with lumbar type HAL in patients with SCA. In this non-randomized open-label single center trial,

Chemical defences, such as the monoterpenes of conifer oleoresin, frequently occur as complex blends of many components, but the selective pressures that maintain these mixtures are not yet known. Several theories attempt to explain the existence of chemical defence mixtures in plants. However, due to limited empirical evidence, it is unclear which theories might best apply. Here, we tested the va

BACKGROUND: Artificial intelligence may improve diagnostic yield and accuracy in syncope.OBJECTIVES: The purpose of this study was to compare Generative Pretrained Transformer 4-Omni (GPT-4o) with medical professionals (MPs) in establishing syncope diagnoses and recommending interventions based on general practitioner's referral letters to a syncope-unit.METHODS: This three-phase study evaluated 5