Gastrointestinal malignancies are one of the major worldwide health concerns. In the present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) against gastrointestinal cancer. By modulating several signaling pathways critical in cancer development, UA could offer anti-inflammatory, anti-proliferative, and anti-metastatic properties. However, being of low oral bioa

Chorea-acanthocytosis (ChAc), an autosomal recessive disorder, is associated with cognitive and behavioral abnormalities. Previous studies were focused around exploring the functional annotation of VPS13A gene in ChAc, whereas the genetic labyrinth underlying this disease and plausible drug targets were underexplored. In the present study, we have identified the pivotal genes and molecular pathway

This article discusses the role of affect in the credibility assessment process in queer asylum claims. Through 27 semistructured interviews with caseworkers, it explores how sexual truth, in the Greek asylum apparatus, is affectively produced and analyses how access to asylum is intermediated by affective control of who is considered the “good” sexual citizen. According to the research material,

The transformation of complex spatial and temporal patterns into mapped and recorded archaeological data requires archaeologists to translate temporally non-distinct processes of exploration into a series of visual recordings of distinct moment of discovery. These visual records, produced by articulating key moments in the excavation process as cleaned and documentable contexts and finds, form a cThe transformation of complex spatial and temporal patterns into mapped and recordedarchaeological data requires archaeologists to translate temporally non-distinct processes ofexploration into a series of visual recordings of distinct moment of discovery. These visual records,produced by articulating key moments in the excavation process as cleaned and documentablecontexts and finds, form a colla

The aim of this article is to describe and analyze the main practices that the Greek Asylum Service applies to assess credibility in asylum claims based on sexual orientation. The analysis is based on a survey of 60 cases (interviews and first instance decisions). According to the results of the survey, the practices used could be divided into two categories. On the one hand, practices that do not

Simultaneous sound event localization and detection (SELD) for multi-source sound events is an open research field. The Multi-ACCDOA format is a popular way to handle activity-coupled sound events where the same class occurs at multiple locations at the same time. An important part is the Auxiliary Duplicating Permutation Invariant Training (ADPIT) paradigm that calculates the loss for order-agnos

Research on inclusive place branding has primarily focused on residents, while tourists are yet to be addressed, except in representation studies. Inclusion is, however, more than a matter of representation. It must also consider the needs of the tourists. This study explores people with foreign backgrounds' anticipated constraints to domestic tourism. This article advances knowledge of inclusive

Climate change mitigation requires the large-scale deployment of carbon capture and storage (CCS). Recent plans indicate an eight-fold increase in CCS capacity by 2030, yet the feasibility of CCS expansion is debated. Using historical growth of CCS and other policy-driven technologies, we show that if plans double between 2023 and 2025 and their failure rates decrease by half, CCS could reach 0.37

When oppositely charged polymers and surfactants combine, they can form a concentrated phase rich in micelles interconnected by polymer chains. Dispersing this concentrated phase as nanoparticles in an aqueous media can be a way to load and deliver hydrophobic ingredients. This study employed triblock copolymers of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), EOxPOyEOx, also kn

For many severe lung diseases, non-invasive biomarkers from imaging could improve early detection of lung injury or disease onset, establish a diagnosis, or help follow-up disease progression and treatment strategies. Imaging of the thorax and lung is challenging due to its size, respiration movement, transferred cardiac pulsation, vast density range and gravitation sensitivity. However, there is

This explorative study investigates the emergence of gray zone markets from search engines amidst the global expansion of online markets. With the analytical approach of infrastructural inversion, we examine how the search infrastructure constructs access to a gray zone market including both authorized online pharmacies and unauthorized vendors. Using Sweden and Google Search as a case, we explore

Det är hög tid att bryta den osynlighetsprincip som funnits under hela efterkrigstidenrörande de skatter och avgifter som löntagarna betalar. Det skriver nationalekonomernaLars Jonung och Erik Norrman.

Acute-phase inhibition of the pro-inflammatory alarmin S100A8/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms underlying the long-term benefits of this short-term treatment remain to be elucidated. Here, we assessed the effects of S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 on myocardial neovascularization in mice with induced MI. The treatment

The lifestyle and consumption patterns of the wealthy exceed our planet's ecological limits. Surprisingly, little experimental research explores the effectiveness of choice architecture interventions targeting the lifestyles and consumption behaviours of the affluent. Addressing this gap, our study investigates the extent to which the top income decile in Sweden can be motivated to take climate ac

Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, with an important role in CRC tumorigenesis, and are either upregulated or downregulated in various cancers. RNA-binding proteins (RBPs) are known as essential regulators of miRNA activity. Human antigen R

Based on a new deep drilling on southern Gotland (Sweden), this study is the first to document the carbon isotope chemostratigraphy of the Upper Ordovician through lowermost Silurian sedimentary record from the central parts of the Baltic Sea subsurface. The lithological record of the Stora Sutarve core has similarities with adjacent successions in both the Viki core in the East Baltic area and th