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Relative survival in patients with dementia with Lewy bodies and Parkinson’s disease dementia

IntroductionThe understanding of survival in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) is limited, as well as the impact of these diagnoses in an ageing co-morbid population.MethodsA retrospective study of 177 patients who received a DLB or PDD diagnosis between 1997–2014 at the Memory Clinic in Malmö, Sweden. Relative survival was evaluated by adjusting all-cause surv

Living with Lewy body dementia. Treatment, survival & quality of life.

Background: Patients with Lewy body dementias (LBD) have a complex clinical picture. With no prevention or cure, management focuses around symptomatic relief, however pharmacological and non-pharmacological options have been inadequately investigated. Moreover, the understanding of survival, prognostic factors and impact of the diagnosis in an already ageing and comorbid population is limited. Eve

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes

Objectives: The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). Background: Assessment of coronary stenosis severity with pressure guidewires is recommended to determine

Analysis of C3 gene variants in patients with idiopathic recurrent spontaneous pregnancy loss

Miscarriage is the most common complication of pregnancy. Approximately 1% of couples trying to conceive will experience recurrent miscarriages, defined as three or more consecutive pregnancy losses and many of these cases remain idiopathic. Complement is implicated both in the physiology and pathology of pregnancy. Therefore, we hypothesized that alterations in the C3 gene could potentially predi

Climate information preserved in seasonal water isotope at NEEM : Relationships with temperature, circulation and sea ice

Analyzing seasonally resolved δ18O ice core data can aid the interpretation of the climate information in ice cores, also providing insights into factors governing the δ18O signal that cannot be deciphered by investigating the annual δ18O data only. However, the seasonal isotope signal has not yet been investigated in northern Greenland, e.g., at the NEEM (North Greenland Eemian Ice Drilling) ice

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In this study, we used cell culture and mouse models of huntingtin protein aggregation as well as post-mortem material from patients with Huntington's disease to

Surveillance for late effects in childhood cancer survivors

Many childhood cancer survivors carry a significant risk for late morbidity and mortality, a consequence of the numerous therapeutic exposures that contribute to their cure. Focused surveillance for late therapy-related complications provides opportunities for early detection and implementation of health-preserving interventions. The substantial body of research that links therapeutic exposures us

Geometry based channel models with cross- and autocorrelation for vehicular network simulations

Realistic network simulations are necessary to assess the performance of any communication system. In this paper, we describe an implementation of a channel model for vehicle-to-vehicle (V2V) communication in the OMNeT++/Plexe simulation environment. The model is based on previous extensive measurements in a V2V multilink highway scenario and cover line-of-sight (LOS) as well as obstructed LOS (OL

The Kobresia pygmaea ecosystem of the Tibetan highlands – Origin, functioning and degradation of the world's largest pastoral alpine ecosystem: Kobresia pastures of Tibet

With 450,000 km2 Kobresia (syn. Carex) pygmaea dominated pastures in the eastern Tibetan highlands are the world's largest pastoral alpine ecosystem forming a durable turf cover at 3000–6000 m a.s.l. Kobresia's resilience and competitiveness is based on dwarf habit, predominantly below-ground allocation of photo assimilates, mixture of seed production and clonal growth, and high genetic diversity.

Validation of a Real-Time Geometry-Based Stochastic Channel Model for Vehicular Scenarios

The performance of wireless communication systems is fundamentally determined by wireless communication channel properties. Wireless vehicular communication channels exhibit multipath propagation and non-stationary channel statistics. Methods and tools for the repeatable test of wireless communication systems and signal processing algorithms in such environments are urgently needed to enable the d

Professional blinders? The novel as an eye-opener in organizational analysis

Scholarly textbooks often follow a logic where suitable empirical cases are selected to illustrate the theoretical and analytical points that we as scholars want to make. But what would happen if we would do the opposite: build a textbook on a novel written by a novelist for such purpose and let the theories explain the actions and emotions of fictional characters? In this article, we share and reScholarly textbooks often follow a logic where suitable empirical cases are selected to illustrate the theoretical and analytical points that we as scholars want to make. But what would happen if we would do the opposite: build a textbook on a novel written by a novelist for such purpose and let the theories explain the actions and emotions of fictional characters? In this article, we share and re