Investigating the Genetic Basis and Functional Implications of High-Affinity Antibodies Targeting Grass Pollen Allergen Phl p 5
Grass pollen allergens, including Phl p 5 from Phleum pratense, are major triggers of seasonal allergic rhinitis, primarily mediated by IgE antibodies. This study investigates the genetic basis and functional characteristics of IgG1 antibodies targeting Phl p 5, possibly derived from type 2 memory B cells predisposed to IgE switching. Using site-directed mutagenesis, we analyzed variants of a high
