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An inverse relationship between low-density lipoprotein uptake and cell density was observed in rat hepatocyte monolayers incubated with lipoprotein-deficient serum. This was also true for cell association, binding and degradation of low-density lipoproteins. Compactin stimulated cell association and degradation of low-density lipoproteins both at low and high concentrations. Insulin, on the other
Invited discussion of D. K. Nelkin, Making Sense of Freedom and Responsibility (Oxford University Press, 2011)
This chapter argues against the claim that morally ignorant wrongdoers are open to blame only if they are culpable for their ignorance, and argues against a version of skepticism about moral responsibility that depends on this claim being true. On the view defended, the attitudes involved in blame are typically responses to the features of an action that make it objectionable or unjustifiable from
I argue that it is possible to prevent (and to be praiseworthy for preventing) an unwelcome outcome that had no chance of occurring. I motivate this position by constructing examples in which it makes sense to explain the non-occurrence of a certain outcome by referring to a particular agent's intentional and willing behavior, and yet the non-occurrence of the outcome in question was ensured by fa
