The misfolding and aberrant aggregation of proteins into fibrillar structures is a key factor in some of the most prevalent human diseases, including diabetes and dementia. Low molecular weight oligomers are thought to be a central factor in the pathology of these diseases, as well as critical intermediates in the fibril formation process, and as such have received much recent attention. Moreover,

This study illuminates how 25 in-patients who were treated for anorexia nervosa in a highly specialized clinic for eating disturbances in Sweden experienced the treatment program. The program included structured eating, medication, restrictions in physical activity and supportive dialogues. Patients were also offered semi-standardized NADA ear acupuncture as a complement to relieve stress, anxiety

Purpose: To examine the feasibility of automatic data extraction from clinical radiation therapy (RT) databases at four hospitals to investigate the impact of mean lung dose (MLD) and age on the risk of early respiratory-related death and early overall death for patients treated with RT for non-small-cell lung cancer (NSCLC). Material and methods: We included adult patients with NSCLC receiving cu

The Neptunian satellite system is unusual, comprising Triton, a large (∼2700 km) moon on a close-in, circular, yet retrograde orbit, flanked by Nereid, the largest irregular satellite (∼300 km) on a highly eccentric orbit. Capture origins have been previously suggested for both moons. Here we explore an alternative in situ formation model where the two satellites accreted in the circum-Neptunian d

Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival or neurological outcome for patients randomised to 33 °C or 36 °C, and many hospitals have changed practice. The optimal utilization of TTM is still debated. This study aimed to

High biogenic silica (BSi) concentration occurs sporadically in lake sediments throughout the world, however, the processes leading to high BSi concentrations varies. While BSi formation and preservation is expected to occur in silica-rich environments with high dissolved silicon (DSi) concentrations such as volcanic and hydrothermal inputs, the factors and mechanisms explaining high DSi and BSi c

Sunlight consists of beams of light of broad wavelength ranges, including infrared, visible, and ultraviolet (UV) radiation; X-rays; and γ-rays. Although the UV content of sunlight is relatively low, the human body, especially the human skin, is sensitive to UV rays. Mica is known to be effective in protecting the human skin from sunlight and reduces fine lines and pores on the skin. Mica is curre

Cloud computing, owing to its ubiquitousness, scalability and on-demand ac- cess, has transformed into many traditional sectors, such as telecommunication and manufacturing production. As the Fifth Generation Wireless Specifica- tions (5G) emerges, the demand on ubiquitous and re-configurable computing resources for handling tremendous traffic from omnipresent mobile devices has been put forward.

Temperature governs most biotic processes, yet we know little about how warming affects whole ecosystems. Here we examined the responses of 128 components of a subarctic grassland to either 5–8 or >50 years of soil warming. Warming of >50 years drove the ecosystem to a new steady state possessing a distinct biotic composition and reduced species richness, biomass and soil organic matter. However,

Background: In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effects in a large cohort of Nordic soft-tissue sarcoma survivors has not yet been assessed. Methods: In this population-based cohort study we identified 9

Objective: To investigate the frequency, predictors, and outcomes of neurologic injury in adults treated with postcardiotomy extracorporeal membrane oxygenation (PC-ECMO). Design: A retrospective multicenter registry study. Setting: Twenty-one European institutions where cardiac surgery is performed. Participants: A total of 781 adult patients who required PC-ECMO during 2010 to 2018 were divided

Objectives: Patients with Staphylococcus aureus bacteraemia (SAB) at risk for infective endocarditis (IE) need to be identified because they should undergo echocardiography. We validated previous scoring systems for IE risk determination and evaluated whether time to blood culture positivity (TTP) could improve scoring systems. Methods: This retrospective population-based study included adults wit

The CHaracterising ExOPlanet Satellite (CHEOPS) was selected on October 19, 2012, as the first small mission (S-mission) in the ESA Science Programme and successfully launched on December 18, 2019, as a secondary passenger on a Soyuz-Fregat rocket from Kourou, French Guiana. CHEOPS is a partnership between ESA and Switzerland with important contributions by ten additional ESA Member States. CHEOPS

Background: The standard reference region (RR) for amyloid-beta (Aβ) PET studies is the cerebellar grey matter (GMCB), while alternative RRs have mostly been utilized without prior validation against the gold standard. This study compared five commonly used RRs to gold standard plasma input-based quantification using the GMCB. Methods: Thirteen subjects from a test–retest (TRT) study and 30 from a

The constant increase in global energy demand makes it inevitable to find clean means of energy production. Among renewable energy sources, the Sun is the most available source which makes it a versatile solution for energy needs. Tremendous efforts are made to invent and develop new materials for light to energy conversion. The main question is how the newly developed materials react to light and