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Structure and function of α-glucan debranching enzymes

α-Glucan debranching enzymes hydrolyse α-1,6-linkages in starch/glycogen, thereby, playing a central role in energy metabolism in all living organisms. They belong to glycoside hydrolase families GH13 and GH57 and several of these enzymes are industrially important. Nine GH13 subfamilies include α-glucan debranching enzymes; isoamylase and glycogen debranching enzymes (GH13_11); pullulanase type I

The topography of mutational processes in breast cancer genomes

Somatic mutations in human cancers show unevenness in genomic distribution that correlate with aspects of genome structure and function. These mutations are, however, generated by multiple mutational processes operating through the cellular lineage between the fertilized egg and the cancer cell, each composed of specific DNA damage and repair components and leaving its own characteristic mutationa

Coastal Erosion in Mozambique : Governing Processes and Remedial Measures

Coastal erosion in Mozambique: Governing processes and remedial measures. Mozambique's 2800-km-long coastline comes with associated vulnerability to coastal erosion, their processes, and resulting evolution. In fact, coastal erosion has been identified as a dominant phenomenon in the Mozambican coastal system. It is driven by a combination of natural processes and anthropogenic actions. Despite th

Paving the way for new regional industrial paths : actors and modes of change in Scania’s games industry

Recent scholarly work has enhanced our understanding of how new path development activities are enabled or constrained by ‘regional environments’, made up of pre-existing industrial structures, knowledge organizations, support structures and institutional configurations. This paper moves beyond overly static views on regional environments. We develop a dynamic perspective by analysing conceptually

Defining donor and acceptor strength in conjugated copolymers

The progress in efficiency of organic photovoltaic devices is largely driven by the development of new donor–acceptor (D–A) copolymers. The number of possible D–A combinations escalates rapidly with the ever-increasing number of donor and acceptor units, and the design process often involves a trial-and-error approach. We here present a computationally efficient methodology for the prediction of o

Half-a-billion-year-old microscopic treasures-the Cambrian 'Orsten' fossils of Sweden

The creatures that gaze back at us through the binocular microscope are so uniquely well-preserved and life-like that had we not known better we would have thought that they were modern. Instead they are half-a-billion-year-old arthropods extracted from Cambrian rocks of Sweden. The microscopic fossils, colloquially known as the 'Orsten' fossils, are now world-famous and basking in the light of th

Acoustic Force Density Acting on Inhomogeneous Fluids in Acoustic Fields

We present a theory for the acoustic force density acting on inhomogeneous fluids in acoustic fields on time scales that are slow compared to the acoustic oscillation period. The acoustic force density depends on gradients in the density and compressibility of the fluid. For microfluidic systems, the theory predicts a relocation of the inhomogeneities into stable field-dependent configurations, wh

Pre-activation negativity (PrAN) in brain potentials to unfolding words

We describe an ERP effect termed the ‘pre-activation negativity’ (PrAN), which is proposed to index the degree of pre-activation of upcoming word-internal morphemes in speech processing. Using lexical competition measures based on word-initial speech fragments (WIFs), as well as statistical analyses of ERP data from three experiments, it is shown that the PrAN is sensitive to lexical competition a

Birth Weight in the Long Run

We study the effect of birth weight on long-run outcomes using data on Swedish twins born between 1926 and 1958 linked to administrative records spanning entire life-time labor market histories. We find that birth weight positively affects permanent income and income across large parts of the lifecycle. The timing of the birth weight–income relationship is in line with the role of birth weight in

'A Fool for Christ' : Sense-Making and Negotiation of Identity in the Life Story of a Christian Soldier

This chapter presents a narrative analysis of the life story of a Swedish Pentecostal who decided to join the Israeli Defense Forces out of his conviction that God wanted him to protect the chosen people. His story is treated as an example of lived Christian Zionism; as one of many manifestations that contemporary Christian affection for Israel can take. The analysis focuses on the central narrati

A Unifying Framework for Robust Synchronization of Heterogeneous Networks via Integral Quadratic Constraints

A general framework for analysing robust synchronization in large-scale heterogenous networks is proposed based on the theory of integral quadratic constraints (IQCs). Dynamic agents are represented as linear time-invariant single-input-single-output systems. The agents exchange information according to a sparse dynamical interconnection operator in order to achieve synchronization, where their ou

Computational optimization of the internal cooling passages of a guide vane by a gradient-based algorithm

To keep the spatially averaged temperature and thermal stress of gas turbine blades and guide vanes within a permissible level, the present research concentrates on the optimization of the internal cooling passages in a guide vane. The main purpose is to search for the most optimal sizes, distributions, and shapes of internal cooling channels located in a guide vane. Cylindrical cooling passages a