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Expression of mutant huntingtin (htt) protein has been shown to cause metabolic imbalance in animal models of Huntington disease (HD). The pathways involved are not fully understood but dysfunction of both the hypothalamus and brown adipose tissue (BAT) has been implicated. Here we show that targeted expression of mutant HTT in the hypothalamus leads to loss of the A13 dopaminergic cell group loca
This Letter reports the observation of a high transverse momentum Z -> b (b) over bar signal in proton-proton collisions at root s = 8TeVand the measurement of its production cross section. The data analysed were collected in 2012 with the ATLAS detector at the LHC and correspond to an integrated luminosity of 19.5 fb(-1). The Z -> b (b) over bar decay is reconstructed from a pair of b-tagged jets
The aim of this study was to gain an understanding of how men living with women with spinal cord injury (SCI) experienced and acted when they were giving and taking social support to and from their wives and other persons in their social network. Another aim was to give some possible explanations of the complex process of change that they went through. Data were collected through in-depth intervie
Popular Abstract in Swedish När en organism utsätts för stress, t. ex. vid hög temperatur, starkt solljus, torka eller köld, produceras särskilda hjälpar-proteiner, s. k. ¨stress-proteiner¨. Syntesen av cellens normala proteiner stängs av och istället produceras bara stress-proteiner. Dessa stress-proteiner är till för att skydda andra protein som skadas under stress. De s. k. ¨värme-stress¨ proteA specific group of heat shock proteins, the so called small heat shock proteins (sHsps), exists in all organisms but are especially abundant in plants. The sHsps prevent aggregation of other proteins (substrate proteins) during transient heat and oxidative stress. Molten globule forms of the substrate proteins are kept in a re-folding competent state by binding onto the outer surface of the sHsp.
Popular Abstract in English 111-Indium is a radioactive isotope that can be chemically linked to different molecules. When this compound is given to patients is distributed heterogeneously within the structures that build up the testicle. Different parts of the so-called germ cells are sensitive to radiation in different ways. Therefore, if a radioisotope that send out electrons with low energies It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution an
Vehicle-to-vehicle (V2V) communications aim to enhance driver safety and traffic efficiency by using the recently designated frequency bands in the 5.9 GHz range in Europe. Due to the time-frequency selective fading behavior of the vehicular communication channel, multi-antenna techniques can provide enhanced link conditions by means of diversity processing. This paper highlights the integration o
This chapter starts with a brief review of research concerning work stress, coping, gender, and health. We also present results from a study which is part of a larger ongoing project: Collective stress and coping at work from a gender perspective. The study puts forth a complementary approach to the individualistic perspective by viewing coping as both an individual and a collective phenomenon. Th
This paper addresses multicarrier communications over the additive white Gaussian noise channel under a power spectral density (PSD) constraint. Depending on the shape of the PSD mask, straightforward power loading according to the waterfilling principle may yield poor throughput results. Several information processing techniques have been proposed to enhance the spectral properties of a multicarr
A reduced four-step scheme for Computational Fluid Dynamics (CFD) analysis is presented here in the context of industrial type laboratory combustor. The present scheme has been optimized for a syngas mixture consisting of 10% CH4, 22.5% CO and 67.5% H2 by volume, and for a methane-air mixture. The optimization of the global scheme is done by comparing with the detailed San Diego mechanism using pe
In 1920, the working day in Swedish industry and services was cut from 10 to 8 hours without wages being cut correspondingly. This change resulted in a dramatic wage push, with real wages increasing by about 50 percent in the years from 1919 to the deflation of 1921–22. This paper studies the consequences of this wage push for real wages, unemployment, profits and investments. Since agriculture wa
A successful previous project E-GIS (Leonardo da Vinci programme) was implemented during 2002-2006. The objectives were to establish co-operation between European Universities and GIS users and to develop modularised courses intended for flexible learning. Ten partners from six European countries (BU, LT, NO, NL, PT, SE) participated. During the project a study program, 100 % Internet based, corre
