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Soccer-Related Concussions Among Swedish Elite Soccer Players : A Descriptive Study of 1,030 Players

Objective: There are growing concerns about the short- and long-term consequences of sports-related concussion, which account for about 5–9% of all sports injuries. We hypothesized there may be sex differences in concussion history and concussion-related symptoms, evaluated among elite soccer players in Sweden. Design: Retrospective survey study. Participants and Setting: Soccer players (n = 1,030

Analysis of neurodevelopmental outcomes of preadolescents born with extremely low weight revealed impairments in multiple developmental domains despite absence of cognitive impairment

Background and aims: Children with extremely low-birth weight (ELBW) have a high risk for cognitive, motor, and attention impairments and learning disabilities. Longitudinal follow-up studies to a later age are needed in order to increase understanding of the changes in neurodevelopmental trajectories in targeting timely intervention. The aims of this study were to investigate cognitive and motor

EUTelescope : A modular reconstruction framework for beam telescope data

EUTelescope is a modular, comprehensive software framework for the reconstruction of particle trajectories recorded with beam telescopes. Its modularity allows for a flexible usage of processors each fulfilling separate tasks of the reconstruction chain such as clustering, alignment and track fitting. The framework facilitates the usage of any position sensitive device for both the beam telescope

Underlying contributing conditions to breathlessness among middle-aged individuals in the general population : A cross-sectional study

Introduction Breathlessness is common in the general population and associated with poorer health. Prevalence, frequencies and overlap of underlying contributing conditions among individuals reporting breathlessness in the general population is unclear. The aim was to evaluate which conditions that were prevalent, overlapping and associated with breathlessness in a middle-aged general population.

A clinical-radiological framework of the right temporal variant of frontotemporal dementia

The concept of the right temporal variant of frontotemporal dementia (rtvFTD) is still equivocal. The syndrome accompanying predominant right anterior temporal atrophy has previously been described as memory loss, prosopagnosia, getting lost and behavioural changes. Accurate detection is challenging, as the clinical syndrome might be confused with either behavioural variant FTD (bvFTD) or Alzheime

Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID-19 Pandemic

Background: The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present he

A randomised controlled trial of integrated psychological therapy for traumatic stress and substance use among adolescents: Trial protocol

Introduction: Post-traumatic stress disorder (PTSD) and substance use disorder frequently co-occur and tend to have their onset during adolescence. Although research has highlighted the importance of treating these disorders in an integrated fashion, there is a dearth of empirically validated integrated treatment options for adolescents with this comorbidity. This paper describes the study protoco

Runtime Modeling and Analysis of IoT Systems

Internet-of-things systems are difficult to understand and debug due to their distributed nature and weak connectivity. We address this problem by using relational reference attribute grammars to model and analyze IoT systems with unreachable parts. A transitive device-dependency analysis is given as an example.

Feature-Oriented Control Programming

Managing variability in control programs often requires code duplication or that all variants are anticipated in advance. In this paper, we present a new approach to obtaining modular functionality reuse across variants. Using the language mechanisms diagram inheritance and connection interception, a feature model and an interactive feature-selection wizard can be automatically derived from the co

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide (Aβ) is a causative process in Alzheimer’s disease, has driven many therapeutic efforts for the past 20 years. Failures of clinical trials investigating Aβ-targeted therapies have been interpreted as evidence against this hypothesis, irrespective of the characteristics and mechanisms of action of the therapeu

Edward Marsh and Modern English Poetry

The name Edward Marsh occasionally crops up in handbooks on English literature, where he is mentioned as the editor of the five volumes of Georgian Poetry that appeared from 1912 to 1922. Georgian poetry, however defined, has been decried for the best part of a century, and Marsh’s reputation among representatives of English Literature has been correspondingly lacklustre. This article presents a r

An experimental and kinetic modeling study on nitric oxide formation in premixed C3 alcohols flames

This study provides new quantitative NO concentrations measurements in n-propanol + air and i-propanol + air flames together with a new combustion kinetic model. The heat flux method was employed to stabilize propyl alcohols flames and the initial gas conditions were set to 323 K, 1 atm, and ϕ=0.7-1.4. Saturated laser-induced fluorescence was employed to measure NO concentration in the post-combus

Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells

Background: The neural crest is a transient embryonic stem cell population. Hypoxia inducible factor (HIF)-2α is associated with neural crest stem cell appearance and aggressiveness in tumors. However, little is known about its role in normal neural crest development. Results: Here, we show that HIF-2α is expressed in trunk neural crest cells of human, murine, and avian embryos. Knockdown as well

Systematics for types and effects of RNA variations

Systematics is described for annotation of variations in RNA molecules. The conceptual framework is part of Variation Ontology (VariO) and facilitates depiction of types of variations, their functional and structural effects and other consequences in any RNA molecule in any organism. There are more than 150 RNA related VariO terms in seven levels, which can be further combined to generate even mor

Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease

Objective: There is an urgent need for sensitive, widely available, blood-based screening tests to identify presymptomatic individuals destined to develop Alzheimer's disease (AD). We investigated whether tau detected in plasma by our in-house NT1 assay is specifically altered in AD, and when applied to patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) can serve t

Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease

B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies, have additionally identified critical functions of Blimp-1 in the maintenance o

Novel treatments of glioblastoma in experimental models

One of the major problems with malignant brain tumours, such as glioblastoma multiforme, is that despite being able to remove the major bulk of the tumour through surgery and treating the patients with chemotherapy and radiotherapy, we know that tumour cells have already spread throughout the brain. Furthermore, we now know that the glioblastoma cells effectively suppress the patients’ own anti-tu