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Reproducible porous silicon protein microarrays -chip manufacturing and application to clinical biomarkers

Full 3" wafer scale fabrication of porous silicon chips (pore chip protein arrays -PCPA) is reported. The PCPA is developed for the analysis of protein molecules based on the fluorescence and MALDI-TOF MS detection. The surface porosification process allows the creation of chips with different surface geometries to control the physical properties of the matrix in a highly reproducible way.

Rapid microwave-stimulated fixation of entire prostatectomy specimens

Conventional fixation of large solid surgical specimens is a slow process. Consequently, autolytic damage to tissues may occur if the fixative does not reach the central part of the specimen in time. However, as there is also a time relationship between formalin fixation and antigen masking, fixation for too long can also be detrimental. In seeking the optimum balance for fixation, microwave irrad

Water and heat coupling processes and its simulation in frozen soils : Current status and future research directions

To date, most studies on coupled-water-and-heat processes in frozen soils haves focused on the mechanism of changes in frozen soil and the contribution of climate change, hydrological processes, and ecosystems in cold regions. Several studies have demonstrated considerable improvements in the accuracy of simulating water and heat transfer processes in cold regions. However, substantial differences

Remissyttrande: En långsiktigt hållbar migrationspolitik (SOU 2020:54)

Institutionen för kultur och samhälle vid Linköpings universitet får härmed avge yttrande som utarbetats av professorerna Anna Lundberg och Anders Neergaard.En övergripande utgångspunkt för utredningen har varit att migrationspolitiken ska vara långsiktigt hållbar, human, rättssäker och effektiv. I det följande lämnar vi synpunkter utifrån denna utgångspunkt. Vi menar sammantaget att kommittén int

Patterns of Respiratory Support by Gestational Age in Very Preterm Infants

Introduction: A detailed understanding of respiratory support patterns in preterm infants is lacking. The aim was to explore and visualize this practice in Sweden. Methods: Preterm infants with gestational ages of 22-31 weeks, admitted to neonatal units reporting daily to the Swedish Neonatal Quality Register and discharged alive in November 2015-April 2022, were included in this descriptive cohor

The rise and stall of world electricity efficiency:1900–2017, results and insights for the renewables transition

In the coming renewables-based energy transition, global electricity consumption is expected to double by 2050, entailing widespread end-use electrification, with significant impacts on energy efficiency. We develop a long-run, worldwide societal exergy analysis focused on electricity. Our 1900–2017 electricity world database contains the energy carriers used in electricity production, final end-u

Social genetic effects for drug use disorder among spouses

Aims: Preclinical and human studies suggest that a social partner's genotype may be associated with addiction-related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouse's genotype could be disentangled from potentially confounding rearing environmental effects. Desi

Optimization of Aeration Diffuser System Design : A Simulation Study

The influence of aeration diffuser system design on electricity usage, effluent water quality, and life-cycle cost in biological wastewater treatment was investigated. A plant-wide model was implemented, and simulations were carried out with different process configurations and aeration systems. Model-aided design of new aeration diffuser systems could significantly decrease electricity usage and

Modelling and numerical simulation of remodelling processes in cortical bone : An IGA approach to flexoelectricity-induced osteocyte apoptosis and subsequent bone cell diffusion

Remodelling is an important process in bones in order to maintain bone mass and to recover cracks which naturally develop within the bone material. There is agreement in the literature that the piezoelectric characteristic of bones is one possible initiator of bone remodelling. In recent experimental studies, however, it has been found that cortical bone also exhibits flexoelectric properties whic

The use of multi-zone modelling for tunnel fires

This paper introduces the use of a multi-zone modelling approach for analysing smoke spread in tunnels. The approach suggested in this paper is based on an existing model, i.e., the Multi-Zone Fire model developed for large spaces. The Multi-Zone Fire model has been adapted and modified for tunnel fire scenarios by including features that consider longitudinal ventilation flow, tunnel gradient and

Tendency of soil erosion dynamics by coupling radioisotopes and RUSLE model on the Southeastern Tibetan Plateau in response to climate warming and human activity

Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil eros

Dorsal anterior cingulate cortex activity during cognitive challenge in social anxiety disorder

Background: Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT). Methods: Here, we u

Large-bias spectroscopy of Yu-Shiba-Rusinov states in a double quantum dot

We have performed tunnel transport spectroscopy on a quantum dot (QD) molecule proximitized by a superconducting contact. In such a system, the scattering between QD spins and Bogoliubov quasiparticles leads to the formation of Yu-Shiba-Rusinov (YSR) states within the superconducting gap. In this work, we investigate interactions appearing when one- and two-electron spin states in a double-QD ener

Burden of established cardiovascular disease in people with type 2 diabetes and matched controls : Hospital-based care, days absent from work, costs and mortality

Aims: To assess hospital-based care, work absence, associated costs, and mortality in patients with type 2 diabetes with and without established cardiovascular disease (eCVD) compared to matched controls. Materials and methods: In a population-based cohort study, we analysed individual-level data from national health, social insurance and socio-economic registers for people diagnosed with type 2 d

Design, synthesis, And applications of galectin modulators in human health

Over the last decade, the family of galectin proteins has been identified as key regulators of important biological processes. They bind β-D-galactopyranoside residues in glycoconjugates, and by presenting multiple binding sites, within one galectin or by forming dimers or multimers, they can cross-link glycoproteins and form galectin-glycoprotein lattices. Such lattices formed on the cell surface