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High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NENs) are highly aggressive cancers. The molecular etiology of these tumors remains unclear, and the prevalence of pathogenic germline variants in patients with HG-GEP NENs is unknown. We assessed sequencing data of 360 cancer genes in normal tissue from 240 patients with HG-GEP NENs; 198 patients with neuroendocrine carcinomas (

Online wall temperatures were measured with fiber-coupled phosphor thermometry in a full-scale gas turbine combustor. The combustor was operated with natural gas and up to 100 vol% hydrogen at engine-relevant conditions. Two phosphors were tested for this application, namely YAG:Dy and YAG:Tm;Li. Although YAG:Tm;Li seemed to be the most promising phosphor for this application, it turned out to be

Construction and demolition workers are exposed to high levels of particulate matter (PM) from building materials throughout their working life. Although nano-enabled building materials (NEBMs) may improve the performance and functionality of buildings, concerns are being raised regarding health risks from occupational exposure to PM from NEBMs. In this work, an experimental set-up for integrated

In this work, we demonstrate the capability of the hot-wall metalorganic chemical vapor deposition to deliver high-quality n-AlxGa1−xN (x = 0 – 0.12, [Si] = 1×1017 cm−3) epitaxial layers on 4H-SiC(0001). All layers are crack-free, with a very small root mean square roughness (0.13 – 0.25 nm), homogeneous distribution of Al over film thickness and a very low unintentional incorporation of oxygen at

IMPORTANCE: The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.OBJECTIVE: To determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of i

The objective of this study is to present a text-critical edition of the medieval treatise Maqāla fī l-Faṣd, ‘On Phlebotomy’, attributed to Abū Bakr Muḥammad ibn Zakariyyāʾ al-Rāzī (865-925), a prominent physician and scholar known especially for his expertise in medicine. His contributions as a distinguished medical author and devoted clinician earned him recognition in both Arabic and Latin medi

Aquatic microbial responses to changes in the amount and composition of dissolved organic carbon (DOC) are of fundamental ecological and biogeochemical importance. Parallel factor (PARAFAC) analysis of excitation–emission fluorescence spectra is a common tool to characterize DOC, yet its ability to predict bacterial production (BP), bacterial respiration (BR), and bacterial growth efficiency (BGE)

Background: III-V semiconductor nanowires are envisioned as being integrated in optoelectronic devices in the near future. However, the perspective of mass production of these nanowires raises concern for human safety due to their asbestos- and carbon nanotube-like properties, including their high aspect ratio shape. Indeed, III-V nanowires have similar dimensions as Mitsui-7 multi-walled carbon n

Objective: To evaluate sick leave after meniscal repair vs arthroscopic partial meniscectomy (APM) and, for comparison, vs the general population. Method: Using Swedish register data we included all employed persons aged 19–49 years in the general population of Skåne region and identified those having had meniscus repair or APM in the period of 2005–2012. We retrieved data on sick leave during 1 y

Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways, and downregulation of DNA repair pathways. Cellular aging of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes a predisposition to anemia, a

Relative and absolute intensity-based protein quantification across cell lines, tissue atlases and tumour datasets is increasingly available in public datasets. These atlases enable researchers to explore fundamental biological questions, such as protein existence, expression location, quantity and correlation with RNA expression. Most studies provide MS1 feature-based label-free quantitative (LFQ

Airborne SARS-CoV-2 is considered to play a major role in covid-19 transmission, and several studies have reported its presence in hospital environments, including corridors, patient rooms, cohort rooms and ICUs (Dinoi et al., 2022). The risk of airborne virus have been associated with a number of factors, such as low ventilation, high patient viral load and in some cases, certain medical procedur

Airborne SARS CoV 2 is considered to play a major role in covid 19 transmission, and has been found in several hospital environments. There is a need to investigate the presence of airborne SARS CoV 2 in other hospital areas than traditional infectious disease wards. The results from the present study can contribute to a better understanding of the risk of covid 19 transmission by aerosols at deli

Background: Tamoxifen is an established treatment for breast cancer, but its long-term effects on survival and on secondary cancers are not fully evaluated. Material and methods: We studied 30 years outcome of 4124 postmenopausal patients who were randomized to receive (totally) two or five years of adjuvant tamoxifen. Results: After 5 years of follow-up, when tamoxifen treatment was finished in b

Background/Aims Self-rated health before, during and after pregnancy is important for women s quality of life and promotes bonding between mother and child. However, diverse aspects of care models influence women s experiences during pregnancy. This study aimed to investigate low?risk women s self-rated health during the perinatal period in relation to different models of care in Sweden. Methods A

This article discusses the relationship between undocumentedness, informality, and vulnerability to crime among migrants, using the strain theory as a conceptual framework. Research on victimisation and engagement in crime among migrants is limited, and existing studies tend to focus on one aspect rather than the interplay between the two. This study focuses on the experiences of the Uzbek communi

The diagnosis of Parkinsonian disorders is currently based on clinical criteria, which have limited sensitivity until most dopaminergic neurons are lost. Here we show that cerebrospinal fluid levels of DOPA decarboxylase (DDC) (also known as aromatic L-amino acid decarboxylase) can accurately identify patients with Lewy body disease (LBD) (area under the curve (AUC) = 0.89; PFDR = 2.6 × 10-13) and

With the introduction of information theory in the middle of the 20th century, the concept of noise came to be contrasted with signal. The exhibition Noise to Signal mainly consists of two projects that highlight the relative nature of these terms.The three textile works, all with the title Untitled (Noise), appear abstract but also represent a grainy filter that is usually applied to digital imag