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Incretin-based medications (GLP-1 receptor agonists, DPP-4 inhibitors) as a means to avoid hypoglycaemic episodes

Hypoglycaemia is common in both type 1 and type 2 diabetes and has both acute and long-term consequences. Therefore, a key to proper glucose-lowering therapy in diabetes is to avoid or prevent hypoglycaemia. Incretin therapy (DPP-4 inhibitors and GLP-1 receptor agonists) offers an advantage in this respect, because it reduces glucose with a low risk of hypoglycaemia, both in monotherapy and in com

Stabilization of a turbulent premixed flame by a plasma filament

The mechanism of stabilizing a turbulent premixed methane-air flame using warm filamentary plasma is investigated by using laser diagnostics. First, stabilization of a turbulent jet flame is demonstrated in a setup using a pin-to-pin plasma discharge. The coupled plasma-flame structures were visualized utilizing planar laser-induced fluorescence (PLIF) of formaldehyde (CH2O) and methylidyne radica

Heat transfer prediction and critical heat flux mechanism for pool boiling of NOVEC-649 on microporous copper surfaces

Pool boiling performance of NOVEC-649 was experimentally studied on microporous surfaces prepared by an electrochemical deposition method. Microporous structures contribute to large surface roughness values and provide large quantities of cavities ranging from several hundreds of nanometers to several microns for bubble nucleation. The results show that a maximum enhancement of 600% in heat transf

Trends of land surface phenology derived from passive microwave and optical remote sensing systems and associated drivers across the dry tropics 1992–2012

Changes in vegetation phenology are among the most sensitive biological responses to global change. While land surface phenological changes in the Northern Hemisphere have been extensively studied from the widely used long-term AVHRR (Advanced Very High Resolution Radiometer) data, current knowledge on land surface phenological trends and the associated drivers remains uncertain for the tropics. T

Tailored reduced kinetic mechanisms for atmospheric chemistry modeling

Reduced chemical kinetic mechanisms are essential for atmospheric chemistry modeling where the use of explicit kinetic schemes is too computationally demanding. By tailoring mechanisms to specific cases, the size of the mechanism can be kept small, without significant loss of accuracy in predictions of selected species’ concentrations. In the present work, we present small kinetic mechanisms tailo

Most gene fusions in cancer are stochastic events

Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have

Precipitating non-aqueous amine systems for absorption of carbon dioxide using 2-amino-2-methyl-1-propanol

The aim of this study was to find a solvent to replace N-methyl-2-pyrrolidone (NMP) in CO2 absorption systems containing the amine 2-amino-2-methyl-1-propanol (AMP), in order to reduce the health risks associated with handling, as NMP is reproductively toxic. Seven organic solvents were investigated: dimethyl sulfoxide (DMSO), 3-(dimethylamino)propionitrile (3DMAPN), 1-pentanol (1 P), propylene ca

Investigation on bluff-body and swirl stabilized flames near lean blowoff with PIV/PLIF measurements and LES modelling

Lean premixed combustion (LPC) is a promising technology for low-NOx emission, while it increases the risk of blowoff at the same time. Experiments and Large Eddy Simulations (LES) on swirl stratified lean-premixed CH4/air flames were performed to study the differences between the stable and near blowoff flame. The flow fields and instantaneous flame structures were measured by simultaneous Partic

Complexation between antimicrobial peptides and polyelectrolytes

As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is

Expression of thermal tolerance genes in two Drosophila species with different acclimation capacities

Heat tolerance increases at higher acclimation temperatures in D. melanogaster, but not in D. subobscura. The two species represent separate lineages of the subgenus Sophophora of Drosophila with contrasting tropical African and temperate Palearctic evolutionary histories. D. melanogaster has five copies of the inducible hsp70 gene distributed in two clusters, named A (with two copies) and B (thre

Post-tsunami survey of the 28 September 2018 tsunami near Palu Bay in Central Sulawesi, Indonesia : Impacts and challenges to coastal communities

Following the 7.5-Mw earthquake that occurred on 28 September 2018, a series of field surveys were performed to further understand the impacts of the resulting tsunami. Tsunamis initiated by strike-slip earthquakes are rare. Other factors are suspected to have contributed to this unusual tsunami. One of these factors was the subaerial landslides around Palu Bay, which were observed at several loca

Identifying predictors of within-person variance in MRI-based brain volume estimates

Adequate reliability of measurement is a precondition for investigating individual differences and age-related changes in brain structure. One approach to improve reliability is to identify and control for variables that are predictive of within-person variance. To this end, we applied both classical statistical methods and machine-learning-inspired approaches to structural magnetic resonance imag

Evaluation of global simulations of aerosol particle and cloud condensation nuclei number, with implications for cloud droplet formation

A total of 16 global chemistry transport models and general circulation models have participated in this study; 14 models have been evaluated with regard to their ability to reproduce the near-surface observed number concentration of aerosol particles and cloud condensation nuclei (CCN), as well as derived cloud droplet number concentration (CDNC). Model results for the period 2011-2015 are compar

Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer's disease spectrum

Background: Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to examine in vivo associations between tau pathology, quantified with [18F]flortaucipir PET in regions corresponding to Braak stages, and atrophy across the Alzheime

Gender but not diabetes, hypertension or smoking affects infarct evolution in ST-elevation myocardial infarction patients - Data from the CHILL-MI, MITOCARE and SOCCER trials

Background: Infarct evolution rate and response to acute reperfusion therapy may differ between patients, which is important to consider for accurate management and treatment of patients with ST-elevation myocardial infarction (STEMI). The aim of this study was therefore to investigate the association of infarct size and myocardial salvage with gender, smoking status, presence of diabetes or histo

Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion

Background: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations performed at our clinic using EVLP lungs vs. conventional lungs. Method: Between 2006 and 2007, 21 patient

Elevated faecal calprotectin is linked to worse disease status in axial spondyloarthritis : Results from the SPARTAKUS cohort

Objectives. To examine faecal calprotectin (F-calprotectin) levels and presence of anti-Saccharomyces cerevisiae antibodies (ASCA) and their associations with disease subtype and current status in axial SpA (axSpA). Methods. F-calprotectin and ASCA in serum were compared between consecutive patients with a clinical axSpA diagnosis, classified as non-radiographic axSpA (nr-axSpA; n = 40) or AS (n =