Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy,

Emboldened by the aesthetic,- emotional-, and corporeal turns in the study of world politics, International Relations (IR) scholars are increasingly paying attention to the political dimension of affects and emotions. Yet while, so far, affect and emotions have been studied as (micro-political) forces that circulate between bodies in the context of the everyday, little attention has been given to

Background Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods For the discovery sample, we did a genome-wide analysis of common genetic variants associated with inc

Background: Lung cancer patients have a risk of recurrence even after curatively intended surgery. Cell-free circulating tumor DNA (ctDNA) and circulating tumor marker measurements are easily accessible through peripheral blood and could potentially identify patients with worse prognosis. The aim of this study was to examine ctDNA in pre-operative plasma and the role of tumor markers in pre-operat

Abstract på danska:Artiklen læser det eksperimentende bog-værk S. (2013), af Doug Dorst og J.J. Abrams, som en refleksion over, og et udtryk for den trykte romans forandrede status i en digital tidsalder. Som en eksperimenterende roman med gulnede sider og håndskrift i marginen synes S. at reflektere en materiel vending i literaturen. Den idealiserer bogmediet som et rum for materialitet og intimiThis article reads J. J. Abrams and Doug Dorst's S. (2013) as a reflection of the changing status and function of the printed novel in the digital age. As an experimental novel with yellowing pages and handwriting in the margins, S. appears to reflect a “material turn” in literature. It celebrates the book as a space of intimacy and memory, positioned in opposition to new digital media. However, t

Literary culture has recently become aware of the printed book as an object and a medium. The spread of new media results in a situation, where the book can no longer be taken for granted and therefore, it requires new cultural and commercial value. The article investigates how the changing status and function of the printed book in contemporary culture is reflected in two recent experimental nove

Artiklen sætter fokus på en nylig materiel vending i litteraturen; en ny opmærksomhed mod litteraturens materielle diensioner som præger både litteraturkritikken olitteraturen selv. Med udgangspunkt i litterære materialitetsteorier af bl.a. Bill Brown og N. Katherine Hayles undersøger jeg, hvordan denne tendens kommer til udtryk i to værker, Anne Carsons Nox og Oscar K.s Af Olafur Kjartanssons opt

The article discusses a tendency towards “media nostalgia” in contemporary experimental literary works.Authors such as Jonathan Safran Foer, Reif Larsen, Anne Carson, Steven Hall, Umberto Eco, J.J. Abramsand Doug Dorst include images, drawing and photographs in their works, or they experiment with the visualand material qualities of writing and the book. The tendency can be explained as a reflecti

This article discusses a ‘material turn’ in contemporary literature in relation to two recent works: Anne Carson’s NOX (2009) and Oscar K’s Af Olafur Kjartanssons optegnelser om den skjulte skrift (2011). Both works experiment with the medium of the book and modes of writing and print. They confront the book with other media and materials such as photographs, fragments of letters, and handwritten

In her article "Intermedial Strategies and Memory in Contemporary Novels" Sara Tanderup discusses a tendency in contemporary literature towards combining intermedial experiments with a thematic preoccupation with memory and trauma. Analyzing selected works by Steven Hall, Jonathan Safran Foer, and Judd Morrissey and drawing on the theoretical perspectives of N. Katherine Hayles (media studies) and

The article traces the development of narrative complexity in the book and television versions of Lemony Snicket's A Series of Unfortunate Events. The series has been criticized for its repetitive structure; however, drawing on seriality theory by Umberto Eco, Jason Mittell and Frank Kelleter, I demonstrate how it does move beyond repetition and towards a more complex narrative structure. I point

Recently, several literary works have appeared which use formal experiments and intermedial strategies to thematize memory and history. Authors such as Alexander Kluge, W.G. Sebald, Daniel Mendelsohn, Monica Maron, Jonathan Safran Foer, Don DeLillo and Aleksandar Hemon include other, primarily visual, media such as film, photographs and drawings, in their works while dealing with historical events

Artiklen fokuserer på intermedialitet som erindringsstrategi i nyere litteratur. Fokus er på såkaldte foto-romanerr af Alexander Kluge, W.G. Sebald, Aleksandar Hemon og Jonathan Safran Foer. Med udgangspunkt i W.J.T. Mitchells teori om forholdet mellem ord og billede påpeges en spænding inden for genren: de moderne foto-romaner synes udspændt mellem, på den ene side, en modernistisk tradition, som

Following a ‘boom’ in audiobook consumption, recent years have seen the emergence of born-audio literature: narratives written specifically for the audiobook format. The article focuses on the content and usage of born-audio serial narratives produced by the Swedish audiobook subscription service, Storytel. As these so-called Storytel Originals are produced specifically for the audiobook format, t