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Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly through overexpression models that suggest a possible gain of toxic misfunction. However, its effects under endogenous conditions are largely unknown

Tourism research does not exist in a vacuum. It is affected not only by changes in tourism consumption and production, but also wider global events and the shifting priorities and policies of higher education institutions and research funders which have placed a stronger emphasis on assessments research output quality, public-private partnerships and relevance (however defined). The constant fluid

A comprehensive approach to ecological functional zoning in the Shenzhen region of China is presented in this study. Through the integration of advanced geospatial analysis tools, multiple data sources, and sophisticated statistical techniques, different ecological functions have been identified and categorized based on a comprehensive set of indicators and spatial analysis techniques. The three-l

Background Task-sharing of spinal anaesthesia care by non-specialist graduate physicians, termed medical officers (MOs), is commonly practised in rural Indian healthcare facilities to mitigate workforce constraints. We sought to assess whether spinal anaesthesia failure rates of MOs were non-inferior to those of consultant anaesthesiologists (CA) following a standardised educational curriculum. Me

Background Mothers attending prevention of mother-to-child transmission (PMTCT) of HIV clinics seem to lack knowledge on many aspects of PMTCT, among which is breastfeeding. Breastfeeding recommendations in PMTCT have changed several times over the years leaving some confused and doubtful of what is currently recommended. One method shown to help improve their knowledge and acceptance of PMTCT rec

Although its role has been debated, temporal artery biopsy (TAB) remains the gold standard for the diagnosis of cranial giant cell arteritis (GCA). The specificity of TAB is excellent and the sensitivity, albeit lower, is comparable with other diagnostic modalities used for the diagnosis of GCA. This outpatient procedure has a low rate of complications and is well integrated in the majority of hea

This guide Addressing Inner Dimensions for Sustainability in Higher Education is aimed at Higher Education faculty from diverse disciplines. The target group is interested in expanding their sustainability knowledge and perspectives, integrating sustainability into their teaching practices, and enhancing their sustainability-related teaching approach by addressing inner dimensions. By inner dimens

INTRODUCTION: We aimed to develop an algorithm to predict the individualized risk of future dementia using brief cognitive tests suitable for primary care. METHODS: We included 612 participants with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, assessed for at least 4 years or until progression to dementia.

Objective: Inverse associations between systemic inflammation and cholesterol (‘the lipid paradox’) have been reported in rheumatoid arthritis (RA) and, in established axial spondyloarthritis (axSpA), but little is known about this relationship in early axSpA, which is the focus of the present study. Method: In the Swedish part of the SPondyloArthritis Caught Early (SPACE) cohort (patients with ch

Introduction: Surgical treatment of distal femoral fractures (DFFs) in osteoporotic bone is challenging despite improvements in hardware and surgical techniques. The occurrence and degree of secondary displacement during healing after bridging plate fixation are still unknown. This study aimed to assess the occurrence and degree of secondary displacement in healing DFFs in elderly patients and cor

Despite the important interrelationships between transport and tourism, research on public transport and tourism remains limited. The role of transport can be generally seen as: an essential/utility of bringing the tourists to tourism destinations and enabling them to move between places at the destinations (transport for tourism); and/or transport that is used as part of the tourism attractions t

Since the agreement of the Millennium Development Goals, many of the international community’s foremost stabilisation efforts have unravelled, with cascading instability afflicting neighboring states. Multiple governments and political entities have begun to turn away from long-term Western security partnerships, and realign with actors such as Russia. This realignment has been pursued even though

An important aspect of microbiological surveillance is the ability to access live viruses for microneutralization assays, which enables the study of viral characteristics and mechanisms in vitro and production of positive controls for diagnostic methods. During the COVID-19 pandemic, the Public Health Agency of Sweden established a protocol for the rapid collection of clinical samples and subseque

Little is known about the aetiology of thymoma. This study aims to identify medical risk factors for thymoma as a systematic approach to new hypotheses on the aetiology of this disease. A European multi-centre case–control study was conducted from 1995 to 1997, including incident cases aged 35–69 years with thymoma. Altogether, we accepted 85 cases and 3350 controls, of which we interviewed 77 cas

The European Colloid and Interface Society (ECIS) was founded in 1986 to provide a European meeting place for scientists interested in colloids and surfaces, including both chemists, physicists, biologists, and colleagues interested in applications. The annual September conferences have from the start attracted strong interest and in recent years 500-1000 scientists from most European countries ha

Objective: To systematically evaluate which lesion-based imaging features and methods allow for the best statistical prediction of poststroke deficits across independent datasets. Methods: We utilized imaging and clinical data from three independent datasets of patients experiencing acute stroke (N1 = 109, N2 = 638, N3 = 794) to statistically predict acute stroke severity (NIHSS) based on lesion v

Based on ethnographic fieldwork, this article is concerned with how undocumented refugees and migrants use invisibility strategies to navigate a hostile host environment in Western Tanzania. This article explores how the shifts in Tanzania’s refugee policy have affected different generations of refugees differently, and how older cohorts assist newer cohorts. This article argues that the challenge

Background: Even though children after tonsil surgery experience pain and other limitations in their daily lives, nursing care is transferred to parents after tonsil surgery, and they might need some kind of support. The aim of the study was to test the design of a randomized controlled trial intended to evaluate a nurse-led telephone follow-up after tonsil surgery on postoperative symptoms and qu

Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A-gene rearrangements (KMT2A-r). However, how these mutations cooperate with the KMT2A-r to remodel the epigenetic landscape is unknown. Using a retroviral acute myeloid leukemia (AML) mouse model driven by KMT2A::MLLT3, we show that FLT3ITD, FLT3N676K, and NRASG12D remodeled the chromatin accessibility landscape and associated