Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that

Recent technological advances have facilitated and diversified the options available for the diagnosis of cardiac arrhythmias. Ranging from simple resting or exercise electrocardiograms to more sophisticated and expensive smartphones and implantable cardiac monitors. These tests and devices may be used for varying periods of time depending on symptom frequency. The choice of the most appropriate h

Materials with bimodal grain size distributions have an attractive combination of strength and ductility. Harmonic structure materials are a category of bimodal-structure materials with a specific microstructure design. The deformation mechanisms of such novel materials during the early stages of deformation are not well understood. Thus, we deformed nickel with harmonic structure in tension until

Harmonic-structure (HS) design is one of the most efficient in the family of architected gradient-structure materials recently attracting increasing attention in global material science community due to leading structural performance characteristics. This work studies in situ the mechanics of plastic deformation in HS materials on the example of commercially pure nickel (Ni) during uniaxial tensil

This paper investigates the regulation of publicly organized early childhood education and care (ECEC) in Denmark and Sweden, through the regulatory welfare state (RWS) framework. The analysis focuses on how alterations in funding and quality of care are shaped by governmental and nongovernmental actors at national and local levels of government. Through focused structured analysis, we examine howThis paper investigates the regulation of publicly organized early childhood education and care (ECEC) in Denmark and Sweden, through the regulatory welfare state (RWS) framework. The analysis focuses on how alterations in funding and quality of care are shaped by governmental and nongovernmental actors at national and local levels of government. Through focused structured analysis, we examine how

How neurons can maintain cellular identity over an entire life span remains largely unknown. Here, we show that maintenance of identity in differentiated dopaminergic and serotonergic neurons is critically reliant on the Polycomb repressive complex 2 (PRC2). Deletion of the obligate PRC2 component, Eed, in these neurons resulted in global loss of H3K27me3, followed by a gradual activation of genes

The precise classification of tumors into relevant molecular subtypes will facilitate both future research and optimal treatment. Here, the Lund Taxonomy system for molecular classification of urothelial carcinoma was applied to two large and independent cohorts of non-muscle-invasive tumors. Of 752 tumors classified, close to 100% were of the luminal subtypes, 95% urothelial-like (Uro; UroA, UroB

Background: The marine thermophilic bacterium Rhodothermus marinus can degrade many polysaccharides which makes it interesting as a future cell factory. Progress using this bacterium has, however, been hampered by limited knowledge on media and conditions for biomass production, often resulting in low cell yields and low productivity, highlighting the need to develop conditions that allow studie

A novel membraneless β-glucan/O2 enzymatic fuel cell was developed by combining a bioanode based on buckypaper modified with co-immobilized Agaricus meleagris pyranose dehydrogenase (AmPDH) and Rhodothermus marinus β-glucosidase (RmBgl3B) (RmBgl3B-AmPDH/buckypaper) with a biocathode based on solid graphite modified with Myrothecium verrucaria bilirubin oxidase (MvBOx/graphite). AmPDH was connected

Context. The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massive clusters with similar masses as globular clusters and may hold the key to understanding their formation. Aims. We study star cluster formation in a tidal debris, including the vicinity of three tidal dwarf galaxies, in a massive gas-dominated collisional ring around N

We propose a model with two Higgs doublets and several SU(2) scalar singlets with a global non-Abelian flavor symmetry Q6× Z2. This discrete group accounts for the observed pattern of fermion masses and mixing angles after spontaneous symmetry breaking. In this scenario only the third generation of fermions get their masses as in the Standard Model (SM). The masses of the remaining fermions are ge

The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massiveclusters with similar masses as globular clusters and may hold the key to understanding their formation.Aims.We study star cluster formation in a tidal debris - including the vicinity of three tidal dwarf galaxies - in a massive gas dominatedcollisional ring around NGC 5291. Th

This thesis addresses how graphene can be a valuable asset for surface science studies. Using a combination of X- ray photoelectron spectroscopy, scanning tunneling microscopy, and low-energy electron diffraction, we take advantage of graphene’s sensitivity to changes in its chemical environment to obtain an atomic scale understanding of different reactions occurring above and below the film.As a

The COVID-19 crisis is a global event that has created and amplified social inequalities, including an already existing and steadily increasing problem of employment and income insecurity and erosion of workplace rights, affecting workers globally. The aim of this exploratory study was to review employment-related determinants of health and health protection during the pandemic, or more specifical