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Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B
XAS study of iron speciation in soils and waters from a boreal catchment
Iron (Fe) is a key element, strongly influencing the biogeochemistry of soils, sediments and waters, but the knowledge about the variety of Fe species present in these systems is still limited. In this work we have used X-ray absorption spectroscopy (XAS) to study the speciation of Fe in soils and waters from a boreal catchment in northern Sweden. The aim was to better understand the controls of F
Communication: Delayed asymmetric Coulomb fission of molecular clusters: Application of a dielectric liquid-drop model.
Delayed asymmetric Coulomb fission in size-selected molecular dication clusters has been recorded for the first time. Observations on (NH(3))(n) (2+) clusters show that fragmentation accompanied by charge separation can occur on a microsecond time scale, exhibits considerable asymmetry, and involves a kinetic energy release of ∼0.9 eV. The fission process has been modeled by representing the fragm
Predictors of Ventricular Fibrillation at Reperfusion in Patients With Acute ST-Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention.
Ventricular fibrillation (VF) during reperfusion (rVF) in ST-segment elevation myocardial infarction (STEMI) is an infrequent but serious event that complicates coronary interventions. The aim of this study was to analyze clinical predictors of rVF in an unselected population of patients with STEMI treated with percutaneous coronary intervention (PCI). Consecutive patients with STEMI admitted to a
Centrality Dependence of the Charged-Particle Multiplicity Density at Midrapidity in Pb-Pb Collisions at root s(NN)=2.76 TeV
The centrality dependence of the charged-particle multiplicity density at midrapidity in Pb-Pb collisions at root s(NN) = 2: 76 TeV is presented. The charged-particle density normalized per participating nucleon pair increases by about a factor of 2 from peripheral (70%-80%) to central (0%-5%) collisions. The centrality dependence is found to be similar to that observed at lower collision energies
Blood Pressure Loci Identified with a Gene-Centric Array
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combin
The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.
Infections in cystic fibrosis (CF), often involving Pseudomonas aeruginosa, result from a dysregulated airway immunity where one hallmark is the accumulation of necrotic and apoptotic immune cells, in particular neutrophils. In addition, neutrophils actively release DNA, forming neutrophil extracellular traps (NETs) that contain antimicrobial proteins. Altogether, free DNA in complex with actin ac
Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis.
Platelets have been reported to contribute to inflammation and inflammatory disorders. In the present study, we demonstrate that platelets contribute to the acute response to bacterial infection in a mouse model of invasive Streptococcus pyogenes infection. Thrombocytopenia occurred rapidly in infected animals and this was associated with platelet activation, formation of platelet-neutrophil compl
Blockade of CD27/CD70 pathway to reduce the generation of memory T cells and markedly prolong the survival of heart allografts in presensitized mice
Background: Alloreactive memory T cells are a major obstacle to transplantation acceptance due to their capacity for accelerated rejection. Methods: C57BL/6 mice that had rejected BALB/c skin grafts 4 weeks earlier were used as recipients. The recipient mice were treated with anti-CD154/LFA-1 with or without anti-CD70 during the primary skin transplantation and anti-CD154/LFA-1 or not during the s
Conditional Cash Transfers and Social Mobility: The Role of Asymmetric Structures and Segmentation Processes
This article seeks to advance existing research on conditional cash transfers (CCTs) by centring the analysis of their long-term impact on the reproduc- tion of poverty and exclusion. To date, most analyses and assessments of CCTs’ long-term impact have been based on simulations focused on specific parameters such as income changes and educational attainment. This study takes as its starting point
Pancreaticoduodenectomy - the transition from a low- to a high-volume center.
Abstract Objective. Previous studies have identified a significant volume-outcome relationship for hospitals performing pancreaticoduodenectomy (PD). However, scant information exists concerning the effects of increased caseload of PD within the same hospital. Here, we describe the effects of becoming a high-volume provider of PD. Material and methods. The study group comprised 221 patients who un
A general criterion for evaporative heat transfer in micro/mini-channels
This paper presents a general criterion to classify a channel as micro-channel or macro-channel. Experimental results of saturated-flow boiling heat transfer in micro/mini-channels for both multi- and single-channel configurations were obtained from the literature. The collected database contains 4228 data points, covering a wide range of working fluids, operational conditions, and different micro
Change in quality of life of people with dementia recently admitted to long-term care facilities
AimTo assess which factors are associated with change in quality of life of people with dementia who have recently been admitted to long-term care facilities. BackgroundMany people with dementia will be admitted to long-term care facilities at some point during their disease. It is currently unknown which factors are associated with improvement and/or deterioration of quality of life immediately f
Getting to Sweden, part II: Breaking with Corruption in the Nineteenth Century
Co-Adsorption of Ga(III) and EDTA at the Water-alpha-FeOOH Interface: Spectroscopic Evidence of the Formation of Ternary Surface Complexes
Co-adsorption reactions between metal ions and anionic ligands play important roles in controlling availability and transport of chemical species in natural aquatic environments as well as in industrial processes. A molecular understanding of the properties of the surface species formed provides means to model these reactions in a predictive manner and to exploit them in synthetic routes of modifi
Det internationella systemet - En teori och dess begränsningar
How bilinguals deal with variation: Generic reference in adult German bilinguals
Why Economics Needs to be Distinguished from Physics, and Why Economists Need to Talk to Physicists: A Response to Foster and Holleman
Debt Relief, Investment and Growth
From 1989 to 2004 the donor community provided approximately $400 billion in debt relief to developing countries in an attempt to promote growth and reduce poverty. Using a sample of 118 developing countries, this paper empirically assesses the impact of debt relief on growth via (1) resources made available for investment from reduced debt service payments and (2)improved incentives to invest fro