Cancer is the leading cause of death worldwide, and there is a constant need for new treatmentstrategies. Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways.

The right to leave a country is enshrined in both international human rights law and its European counterpart. It is a right which is independent and does not require the individual exercising it to show that he or she is admissible in some other country. It is exercisable even in the absence of evidence of possible admission to a destination country. However, in Europe (and some other parts of th

Temperature and precipitation extremes are the dominant causes of natural disasters. In this study, seven indices of extreme temperature and precipitation events in Gansu Province, China, were analysed for the period 1961–2017. An abrupt climate shift was recorded during 1980–1981. Thus, the study period was divided into a preshift (before the climate shift) period 1961–1980 and an aftshift (after

The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues

Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 1

Regional and global assessments periodically update what we know, and highlight what remains to be known, about the linkages between people and nature that both define and depend upon the state of the environment. To guide research that better informs policy and practice, we systematically synthesize knowledge gaps from recent assessments of four regions of the globe and three key themes by the In

Over the past several years an increasing number of terrorist attacks committed in the name of Islam and targeting civilians have taken place in many Western democracies, calling for more research on the impact of these exogenous events on citizens’ attitudes towards immigrants. Using a quasi‐experimental design, this study examines the short‐term effect of the Paris attacks of the night of 13 Nov

As interest in the processes of integration of immigrants and ethnic minorities grows among European scholars, the role of multiple actors in shaping civic and political participation by people of migrant background needs to be further examined. Building on the literature on migration, this study addresses the following research question: What accounts for differences in forms of civic and politic

‘You do not know what it means to me, to be at this kind of party, to talk to these kinds of people’, my research assistant Rodrigo told me after a soirée in the elite South Zone of Rio. ‘É uma viagem’, it’s a journey. Rodrigo, who had already worked with three anthropologists by the time I came to be his employer, thrived with the affordances of friendship, in the face of the volatility of his fa

Contemporary social and cultural conditions in Brazil, together with technological developments and social media have enabled more young people of the favela to participate in different spheres of public life. These social and cultural changes have brought diversified new images of what it means to be an embodied subject. In this article, I explore the ways in which the body holds a seemingly para

This article analyzes instances of refusal to eat or drink due to the fear of poisoning and contamination amongst favela youth in Brazil. These particular occurrences of refusal shed light on refusal’s potency as a way of managing complex social entanglements and instrumental in asserting agency. Considering that interlocutors had come of age without many formal institutions present, they needed p