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The development of highly specialized blood cells from hematopoietic stem cells (HSCs) in the bone marrow (BM) is dependent upon a stringently orchestrated network of stage- and lineage-restricted transcription factors (TFs). Thus, the same stem cell can give rise to various types of differentiated blood cells. One of the key regulators of B-lymphocyte development is early B-cell factor 1 (EBF1).
We investigate the use of a highly scalable intervention to help individuals achieve their physical activity goals: self-funded commitment contracts. Using a randomised experiment, we compare the effect of soft (non-incentivised) and hard (incentivised) contracts among 1629 members of a gym in Stockholm, Sweden. We find a significant positive impact of being offered a hard contract on monthly visi
A potential mechanism to explain changes in cooperativeness in the presence of risk may be opportunities for informal risk sharing. Using a novel experimental design, we show that the presence of both independent and correlated risk prevents the typical decay of cooperation in a laboratory social dilemma game. Notably, this result seems to rule out risk sharing as a possible mechanism behind the c
Background: The use of methylisothiazolinone (MI) as a preservative in cosmetic products caused an alarming increase in MI contact allergy across Europe in the 2010s. This was followed by regulations of use with a total ban on leave-on (implemented in 2017) and reduced use concentrations in rinse-off cosmetics (2018). Objective: To follow-up on the prevalence of contact allergy to MI and the relat
Evidence suggests that separate spheres gender norms discourage girls from maths. We therefore examine a policy that counteracts such norms among parents, and investigate whether it increases girls' participation in maths-intensive studies. Specifically, we examine a parental leave reform that reserved one month of leave for fathers, and estimate its effect on children's study choices. We find tha
BACKGROUND: Unemployment is high not only among people with mental illness, but also among young adults in general. The combination of having a severe mental illness and being young entails a particularly problematic situation for young people with psychosis. This study aimed to understand how this group envision their future possibilities for entering the labour market or engaging in other produc
A new species of Horismenus Walker, H. saturnus Schoeninger & Hansson (Hymenoptera: Eulophidae), is described from material reared from eggs of an unidentified species of Saturniidae (Lepidoptera). The new species is compared to H. cupreus (Ashmead, 1894), a species it is very similar to, and to H. ancillus (Brèthes), a species with the same type of host as H. saturnus. A total of 30 adult spe
Social exclusion and individuals’ self-sufficiency have been on the public agenda in Sweden recently. One reason is the large influx of immigrants to Sweden in 2016. This paper aims to measure self-sufficiency over time, across the life cycle, depending on geographical origin, and time spent in Sweden to provide information about how self-sufficiency has developed over time and across the life cyc
Background: Patients in palliative care are often treated with antithrombotics, even in the late stages of disease. Clear guidelines regarding deprescribing are lacking. Objective: The aims of this study were to investigate bleeding as a side effect of antithrombotic treatments the last year in life and map the timing of deprescribing. Methods: A retrospective cohort study was performed. All medic
Aim: To assess experience of care, well-being of parents and children's development in a cohort of extremely premature infants born <24 weeks of gestation in Sweden from 2007 to 2018. Methods: A survey based on multiple questionnaires answered by 124/349 (35.5%) parents. Results: The median age of parents and children was 43 and 9 years, respectively; 74.2% were mothers. Parents expressed high hea
Previous literature has reported increased rates of gambling problems in athletes compared to non-athletes. More liberal gambling-related attitudes have been suggested as a reason, although this rarely has been researched. The present study aimed to examine gambling experience, gambling problems, and gambling-related attitudes and parental gambling experience in high school students, comparing stu
Introduction: Prostate-specific membrane antigen (PSMA) is a target for diagnostic positron emission tomography (PET)-tracers and radiopharmaceutical therapy (RPT), for example, [177Lu]Lu-PSMA-617, in prostate cancer. This autoradiography study investigates [177Lu]Lu-PSMA-617 intratumoral distribution over time, compared with PSMA expression, proliferation (Ki67), and [68Ga]Ga-PSMA-11, [18F]F-PSMA
This paper focuses on contemporary archival professionals in Sweden. The research questions posed are: RQ1: What are the different facets of archival work commonly described in employment advertisements directed at archival professionals? RQ2: What are the desirable personal traits that employers seek when hiring an archival professional? The material consists of job advertisements from the year 2
BACKGROUND: Children with repaired tetralogy of Fallot (rToF) often have pulmonary regurgitation with right ventricular (RV) dilatation and dysfunction, whereas less is known about the effect on the left ventricle (LV). The aim was to investigate LV haemodynamic variables derived from non-invasive pressure-volume loops in children with rToF and how they compare to controls and previous research on
Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on
Objectives. This study aimed to investigate the consistency between results of the American Conference for Governmental Occupational Hygienists (ACGIH) threshold limit value (TLV) for hand activity and proposed action levels of objective measurements in risk assessments of work-related musculoskeletal disorders. Methods. Wrist velocities and forearm muscular load were measured for 11 assemblers du
Aims/Hypotheses: To investigate the frequency and characteristics of partial remission in Swedish children with type 1 diabetes and whether the insulin delivery method, that is, continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDIs), affects incidence and duration of this period, 2007-2011. Factors that increase the proportion of subjects who enter partial remission an
The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD). The present document updates the 2018 research framework in response to several recent developments. Defining diseases biologically, rather than based on synd
