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Vitamin D insufficiency is common, correctable, and influenced by genetic factors, and it has been associated with risk of several diseases. We sought to identify low-frequency genetic variants that strongly increase the risk of vitamin D insufficiency and tested their effect on risk of multiple sclerosis, a disease influenced by low vitamin D concentrations. We used whole-genome sequencing data f
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The aim of this study is to explore the possibility of identifying speaker stance in discourse, provide an analytical resource for it and an evaluation of the level of agreement across speakers in the area of stance-taking in discourse. We explore to what extent language users agree about what kind of stances are expressed in natural language use or whether their interpretations diverge. In order
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The Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE) trial was a 12 month, randomized, open-label, parallel-group trial that compared everolimus (EVR; n=56) to conventional CsA (n=59) immunosuppression. Previously, we reported that EVR outperformed CsA in improving renal function and coronary artery vasculopathy, despite a higher rejecti
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Presently, there is no single, coherent theory on the causality between cities and economic growth, only a fragmented set of theories. Current patterns and trends for the relationship between cities and economic growth, however, suggest that a full understanding of contemporary processes will not be achieved by relying on the tools of one discipline alone, or by focusing on a single level of analyPresently, there is no single, coherent theory on the causality between cities and economic growth, only a fragmented set of theories. Current patterns and trends for the relationship between cities and economic growth, however, suggest that a full understanding of contemporary processes will not be achieved by relying on the tools of one discipline alone, or by focusing on a single level of analy
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Why are female children still at risk in India despite progress in education, increasing participation of women in economic and political activities, and an overall improvement in the status of women? Is there any significant shift from 'son preference' to 'daughter discrimination'? Based on a study of two villages from low-fertility regions of Karnataka and Tamil Nadu, this paper attempts to unde
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The importance of school climate in schooling has been demonstrated consistently over the last 50 years. In this study, we investigate how individual student norms and opinions shape and affect school climate. Through the use of secondary survey data collected within two research projects at eight schools throughout Sweden in two different years, we demonstrate how individual student norms develop
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In this paper, we present a study for the identification of authors’ national variety of English in texts from social media. In data from Facebook and Twitter, information about the author’s social profile is annotated, and the national English variety (US, UK, AUS, CAN, NNS) that each author uses is attributed. We tested four feature types: formal linguistic features, POS features, lexicon-based
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Background: Uncomplicated lower urinary tract infections (UTIs) occur in approximately 50% of women, and 20–30% experience recurrent UTI. Data on UTIs and quality of life (QoL) in Europe are limited. Methods: This was an anonymous, self-administered web-based survey conducted in 5 countries (Germany, Switzerland, Poland, Russia and Italy), on adult women who had experienced recurrent UTI and were
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We evaluated the clinical utility of the Swedish SCARED-R in child- and adolescent psychiatric outpatients (n = 239) and validated it against Longitudinal Expert All Data (LEAD) DSM IV diagnoses based on the Children’s Schedule for Affective Disorders and Schizophrenia (KSADS) and subsequent clinical work-up and treatment outcome. The SCARED-R total score and subscales had acceptable sensitivity/s
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Background: The majority (60%) of left ventricular (LV) stroke volume (SV) is generated by longitudinal shortening causing apical atrioventricular plane displacement (AVPD) in systole. The remaining SV is caused by radial inward motion of the epicardium both in the septal and the lateral wall. We aimed to determine if these longitudinal, septal and lateral contributions to LVSV are changed in pati
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We study how close-in systems such as those detected by Kepler are affected by the dynamics of bodies in the outer system. We consider two scenarios: outer systems of giant planets potentially unstable to planet-planet scattering and wide binaries that may be capable of driving Kozai or other secular variations of outer planets' eccentricities. Dynamical excitation of planets in the outer system r
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OBJECTIVE:: Caesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS:: From 2004 to 2010 infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental D
