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Coastal areas display natural large environmental variability such as frequent changes in salinity, pH, and carbonate chemistry. Anthropogenic impacts – especially ocean acidification – increase this variability, which may affect the living conditions of coastal species, particularly, calcifiers. We performed culture experiments on living benthic foraminifera to study the combined effects of lower
50 years have passed since the first human to human heart transplantation, performed by Christiaan Barnard in Cape Town December 3rd 1967. Over the years there has been a dramatic improvement in postoperative survival, mainly due to numerous diagnostic and therapeutic advances. Today, heart transplantation constitutes the treatment of choice among suitable patients with severe heart failure who wo
Långvarig smärta är ett vanligt förekommande och tärande tillstånd som är bland de mest kostsamma hälsoproblemen för både individen och samhället som helhet. Kognitiv beteendeterapi (KBT) är den mest spridda psykologiska behandlingen för långvarig smärta. Även om metoden är evidensbaserad och rekommenderad ger den relativt blygsamma förbättringar för smärtrelaterad funktion och medföljande emotionChronic pain is a commonly occurring and debilitating condition, and among the costliest health problems for both the individual and society at large. Cognitive behavioral therapy (CBT) is the most widely-disseminated psychological treatment for chronic pain. Even though it is recommended and evidence-based, it yields quite modest improvements in pain-related functioning and accompanying symptoms
Lenalidomide (Len) plus dexamethasone (Dex) is approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It is possible that single-agent Len may be effective as prolonged treatment regimen in RRMM once patients demonstrate an initial response to Len+Dex induction. Patients with RRMM who responded to first-line Len+Dex in an observational study (NCT01430546) received up to 24 c
Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG-degrading enzyme of Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single-center, open-label ascending-dose study in highly sensitized patients with chronic kidney disease. Eight patients with cytotoxic PRAs (median cytotoxic PRAs of 64%) at enrollment received 1 or 2 intravenous infusions of IdeS on consecutive days
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
Objectives: This study aimed to investigate how the use and perceived unmet need of mobility devices (MD) in people with Parkinson's disease (PD) evolve over a 3-year period. Methods: The study reports baseline assessments (n = 255) and comparisons for participants with complete data at baseline and the 3-year follow-up (n = 165). Structured questions addressed the use and perceived unmet need of
Purpose: To analyze risk factors for refractive error after cataract surgery and provide a benchmark for refractive outcomes after standard cataract surgery. setting: One hundred cataract surgery clinics from 12 European countries. Design: Multicenter database study. Methods: Data on consecutive cataract extractions reported to the European Registry of Quality Outcomes for Cataract and Refractive
Until the introduction of dolutegravir (DTG), people living with HIV (PLWH) who have developed nucleoside reverse transcriptase inhibitor (NRTI) mutations have had few other treatment options outside of regimens based on ritonavir-boosted protease inhibitors (PI/r). Here we report treatment results among PLWH in Sweden with pre-existing NRTI mutations on antiretroviral treatment (ART) with DTG and
Purpose: To explore and compare cancer patients' perceptions on the quality of nursing care in four European countries. Methods: Data were collected in Cyprus, Finland, Greece and Sweden. The sample comprised 596 hospitalized cancer patients. The quality of nursing care was measured using the “Oncology Patients' Perceptions of the Quality of Nursing Care Scale” (OPPQNCS). Patient characteristics w
This dissertation deals with memory, recognition and solidarity in the Nowa Huta district of Kraków, Poland. Nowa Huta was founded as an independent, socialist model town in 1949, together with the large Lenin Steel Plant, and was incorporated into Kraków in 1951. In the 1980s the steel plant and district became one of the main centers of the oppositional Solidarity movement in Poland. Situated be
The Younger Dryas (YD) cold reversal interrupts the warming climate of the deglaciation with global climatic impacts. The sudden cooling is typically linked to an abrupt slowdown of the Atlantic Meridional Overturning Circulation (AMOC) in response to meltwater discharges from ice sheets. However, inconsistencies regarding the YD-response of European summer temperatures have cast doubt whether the
Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the hormone-DNA repair circuit to enable molecularly-specific alpha particle irradiation of PCa. Alpha-
Visioner och framtidsbilder efterfrågas ofta för att motivera och inspirera till samhälleliga förändringar. Sådana visioner kan bygga på politisk förändring eller måla upp bilder av teknisk utveckling som hjälper oss att lösa svåra samhälleliga problem. Den typen av visioner är kanske speciellt viktiga när vi strävar efter en hållbar utveckling, och framför allt ifall vi vill motverka att jordens Different kinds of representations of the future are often asked for in order to motivate and inspire societal change. These envisioned futures can be based on political or behavioural change, or may visualize technical developmentwhich could help us solve complex societal problems. The latter type of epresentation is especially important if we aim for sustainable development, and even more so if
Background: Different abdominal symptoms may signal cancer, but their role is unclear. Aim: To examine associations between abdominal symptoms and subsequent cancer diagnosed in the abdominal region. Design and setting: Prospective cohort study comprising 493 GPs from surgeries in Norway, Denmark, Sweden, Scotland, Belgium, and the Netherlands. Method: Over a 10-day period, the GPs recorded consec
Världens skogar lagrar stora mängder kol både som levande biomassa och i marken. Skogarnas förmåga att motverka klimatförändring genom att fungera som kolsänkor har erkänts inom global klimatpolitik, till exempel Parisavtalet från 2015 vilket uppmanar länder att minska sina utsläpp av växthusgaser. Sverige är ett av flera länder med ambitiösa målsättningar och har lovat att inte ha några nettoutslGlobal forests store large amounts of carbon both in living biomass and in the soil. The ability of forests to counteract climate change by acting as carbon sinks have been recognized in global climate politics, such as the 2015 Paris agreement which calls for national commitments to reduce greenhouse gas emissions. Sweden is one of many countries who have pledged ambitious climate goals, promisin
Background: It is unclear to what extent primary care practitioners (PCPs) should retain responsibility for follow-up to ensure that patients are monitored until their symptoms or signs are explained. Aim: To explore the extent to which PCPs retain responsibility for diagnostic follow-up actions across 11 international jurisdictions. Design and setting: A secondary analysis of survey data from the
