The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi-annual forum EUFOREUM in Berlin in November 2023. The aim of EUFOREUM 2023 was to highlight pediatric action plans for prevention and optimizing care for type 2 inflammatory conditions starting in childhood, with a focus on early-stage diagnosis, ensuring neither under- nor overdiagnosis, optim

Digital twins have been gaining an immense interest in various fields over the last decade. Bringing conventional process simulation models into (near) real time are thought to provide valuable insights for operators, decision makers, and stakeholders in many industries. The objective of this paper is to describe two methods for implementing digital twins at water resource recovery facilities and

We prove the first hardness results against efficient proof search by quantum algorithms. We show that under Learning with Errors (LWE), the standard lattice-based cryptographic assumption, no quantum algorithm can weakly automate TC0-Frege. This extends the line of results of Krajíček and Pudlák (Information and Computation, 1998), Bonet, Pitassi, and Raz (FOCS, 1997), and Bonet, Domingo, Gavaldà

Avian flapping strategies have the potential to revolutionize future drones as they may considerably improve agility, increase slow speed flight capability, and extend the aerodynamic performance. The study of live birds is time-consuming, laborious, and, more importantly, limited to the flapping motion adopted by the animal. The latter makes systematic studies of alternative flapping strategies i

From the mid-1960s to the mid 1970s, three new universities were established in Denmark: Odense (1966), Roskilde (1972) and Aalborg (1974). Until then only two universities existed in Denmark: Copenhagen (1479) and Aarhus (1928). Located on the outskirts of the major cities, the new institutions played an important part in reforming and transforming higher education in Denmark. The youngest univer

I Sverige erbjuds förebyggande stödgrupper av socialtjänsten för barn som växer upp i familjer där det förekommer våld, missbruk eller psykisk ohälsa. Stigma som är kopplad till föräldrars problem och till socialtjänstens inblandning utgör hinder för barns deltagande i stödgrupper. I denna artikel undersöks barns och föräldrars upplevda motiv, hinder och fördelar med deltagandet genom att utforskaIn Sweden, preventive support groups for children exposed to domestic violence, substance abuse, or mental illness in the home are provided by local child welfare services. The stigma associated with parental problems and the involvement of child welfare services are barriers to children’s participation in support groups. This article examines the motives, barriers, and benefits according to child

This article is a study of G. E. Söderholm as apologetic writer of the early Swedish Pentecostal movement during the period 1920-1940. It investigates how Söderholm through the symbolic capital his status as a former vicar in the Swedish state church generated and through the use of historical writing defended the Pentecostal movement from polemic academic scholarship about the movement and from c

The t(14;19)(q32;q13) is a rare recurring translocation found in B-cell lymphoproliferative malignancies, involving the Bcl-3 gene. This chromosomal translocation is often found in patients under the age of 50 and causes a more progressive disease. The Bcl-3 gene encodes a protein belonging to the IκB family of proteins, which tightly regulates NFκB signaling by acting as an activator or repressor

Glioblastoma (GB) is the most common and the most aggressive form of brain tumor in adults, which currently lacks efficient treatment strategies. In this study, we investigated the therapeutic effect of function-blocking antibodies targeting integrin α10β1 on patient-derived-GB cell lines in vitro and in vivo. The in vitro studies demonstrated significant inhibiting effects of the integrin α10 ant

Mast cells (MCs) are multifunctional effectors of the immune system that are distributed in many tissues, often in close association with the basement membrane of blood vessels, epithelium and nerves. Laminins (LMs), a family of large alphabetagamma heterotrimeric proteins, are major components of basement membrane that strongly promote cell adhesion and migration. In this study, we investigated t

Providing humoral immunity, antibody-secreting plasma cells and their immediate precursors, the plasmablasts, are generated in systemic and mucosal immune reactions. Despite their key role in maintaining immunity and immunopathology, little is known about their homeostasis. Here we show that plasmablasts and plasma cells are always detectable in human blood at low frequency in any unimmunized dono

Following vascular injury, basement membrane (BM) components of the blood vessels are exposed to circulating cells and may contribute to hemostasis and/or thrombosis. Laminins 8 (LN-8) (alpha4beta1gamma1) and 10 (LN-10) (alpha5beta1gamma1) are major laminin isoforms of the endothelial BM, and LN-8 is also secreted by activated platelets. In the present study, we demonstrate synthesis of alpha5-lam