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Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk
Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabo
Soil microbial diversity in agriculture : Responses to land-use and extreme weather events
Land-use intensification of agricultural soils and increased occurrence and intensity of extreme weather events like drought periods are two of the main threats responsible for soil biodiversity declines. These changes in soil biodiversity can alter ecosystem functions performed especially by soil microbial communities that could further contribute to those threats. Microbial diversity is an essen
Ethnic Composition of Couples and Mutual Health Benefit Receipt: Register-Based Evidence from Finland
The literature on health dependencies among partners typically ignores diversity of partnership characteristics. One salient example is the ethnic composition. We extend prior work on partnerships and health by investigating how married and cohabiting partners mutually influence each other’s receipt of health-related benefits, focusing on how such correlations vary with the couple’s ethnic composi
X-ray in-line holography and holotomography at the NanoMAX beamline
Coherent X-ray imaging techniques, such as in-line holography, exploit the high brilliance provided by diffraction-limited storage rings to perform imaging sensitive to the electron density through contrast due to the phase shift, rather than conventional attenuation contrast. Thus, coherent X-ray imaging techniques enable high-sensitivity and low-dose imaging, especially for low-atomic-number (Z)
Influence of variable oxygen concentration on the combustion derived release of radiocesium from boreal soil and peat
Radiocesium, 137Cs, is one of the most common and dispersed human-made radionuclides. Substantial stocks of 137Cs are stored in organic layers, like soils and peat, as a consequence of nuclear weapons fallout and accidental releases. As climate warming progresses these organic layers are subject to enhanced risks of wildfires, especially in the vast boreal biome of the northern hemisphere. Reemiss
Scaling up nature-based solutions for climate-change adaptation : Potential and benefits in three European cities
Many exemplary projects have demonstrated that Nature-based Solutions (NBS) can contribute to climate change adaptation, but now the challenge is to scale up their use. Setting realistic policy goals requires knowing the amount of different NBS types that can fit in the urban space and the benefits that can be expected. This research aims to assess the potential for a full-scale implementation of
Simulating crowding of urban green areas to manage access during lockdowns
During the COVID-19 emergency, cities around the world introduced measures to guarantee physical distancing that restricted access to urban parks and green areas, with potentially negative effects on citizens’ health and wellbeing. This study aims at providing insights to manage access to urban green space in physical distancing times, when the risk of crowding should be avoided. Using the city of
Who needs anger management? Dismissing young engagement
Areal Precipitation Coverage Ratio for Enhanced AI Modelling of Monthly Runoff: A New Satellite Data-Driven Scheme for Semi-Arid Mountainous Climate
Satellite remote sensing provides useful gridded data for the conceptual modelling of hydrological processes such as precipitation–runoff relationship. Structurally flexible and computationally advanced AI-assisted data-driven (DD) models foster these applications. However, without linking concepts between variables from many grids, the DD models can be too large to be calibrated efficiently. Ther
A CFD study of a pin-on-disc tribometer setup focusing on airborne particle sampling efficiency
One of the most important measures to evaluate air quality is the presence of particles. Pin-on-disc tribometers are used to study airborne wear particles originating from different sliding contacts in a controlled laboratory environment. One important aspect when measuring airborne particles is to ensure isokinetic sampling conditions. Another important aspect is that the concentration and the pa
Does delivery service differentiation matter? Comparing rural to urban e-consumer satisfaction and retention
In the context of continuously growing e-commerce and the rising global count of e-consumers, e-retailers and logistics service providers need to differentiate and tailor their offerings to refine their operations and meet e- consumers’ needs. This study investigates how e-consumers’ residential-area type affects the satisfaction with delivery services and reuse intentions in relation to e-consume
Bone mineral density in haemophilia – a multicentre study evaluating the impact of different replacement regimens
AimThe aim of this study was to investigate if prophylactic treatment in severe haemophilia impact on bone mineral densisty (BMD) in adults with haemophilia A/B.MethodsSubjects with haemophilia (n = 120) underwent bone-density measurement and clinical data was collected. BMD in subjects with severe haemophilia on high-dose prophylaxis (n = 41) was compared to BMD in subjects with mild haemophilia
When do political parties listen to interest groups?
This paper examines when parties listen to interest groups and adopt their input. Interest group information can help parties bolster their positions, and by taking their input into account, parties show that they are responsive to the groups’ interests which can increase their appeal to their constituents. Listening to interest groups can, however, also repel voters who disagree with the groups’
Poly(p-terphenyl alkylene)s grafted with highly acidic sulfonated polypentafluorostyrene side chains for proton exchange membranes
Molecularly well-designed proton exchange membranes (PEMs) with a high local concentration of strongly acidic groups have the potential to fulfill the strict requirements for fuel cell operation under high temperature and low humidity. Here, we have prepared a series of well-defined and tunable PEMs based on poly(p-phenylene alkylene) backbones functionalized with sulfonated polypentafluorostyrene
Roman ports in the lower Tiber valley : computational approaches to reassess Rome's port system
This paper presents an innovative study of the port system of Rome in Imperial times through the application of an integrated approach to both archaeological analysis and material evidence. Specifically, it seeks to provide a more complete contextualization and understanding of the port system of Rome by focusing on the exploration of the physical geography of the river Tiber and its transformatio
Effects of Roman rule on the settlement geography of South Iberia : a GIS-based approach
In the last years, the matter of the Romanization of Baetica has started to receive more attention, thus reactivating a topic largely assumed to be unproblematic in earlier approaches. Stemming from this interest, the present paper reviews theoretical and methodological approaches applied so far in the study of Roman rule in Baetica, before proposing new conceptualizations, research methods and in
The Copper Age in the lands of Antequera (Málaga) : Introduction to the settlement patterns and social dynamics
Antequera (Málaga) is home to one of the most important Neolithic and Copper Age megalithic landscapes in Europe, as proven by its recent declaration as a World Heritage Site by unesco on July 15th 2016. This declaration highlights the need to push ahead in the research of the Neolithic and Copper Age periods, when the megalithic phenomenon developed and the three large Antequera megaliths, Menga,
Formal Modelling Approaches to Complexity Science in Roman Studies : A Manifesto
Complexity science refers to the theoretical research perspectives and the formal modelling tools designed to study complex systems. A complex system consists of separate entities interacting following a set of (often simple) rules that collectively give rise to unexpected patterns featuring vastly different properties than the entities that produced them. In recent years a number of case studies