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Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatment

BACKGROUND: Mild hypothermia is currently standard of care for cardiac arrest patients in many hospitals and a common belief is that hypothermia attenuates platelet aggregation. We wanted to examine the effects of clopidogrel on platelet aggregation during hypothermia.METHODS: Platelet reactivity at 37° C and 33° C was evaluated by light transmission aggregometry and vasodilator-stimulated phospho

Molecular design and synthesis of hydroxide ion exchange membranes carrying alicyclic quaternary ammonium cations

Significantresearch efforts are currently directed towards the synthesis and studies of durable anion exchange membranes (AEMs) with the aim to develop alkaline fuel cells and electrolyzers able to operate efficiently without platinum-groupmetal catalysts [1]. The grand challenge is to identify and synthesize polymeric AEM materials possessingthe necessary chemical and thermal stability. Studies o

Effects of delayed cord clamping on neurodevelopment and infection at four months of age : A randomised trial

Aim To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. Methods Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G

PVL-positiva Staph aureus gav nekrotiserande pneumoni : Beskrivning av tre svära fall hos tidigare friska unga

We describe three cases of community-acquired pneumonia, in which the causative agent was methicillin sensitive S. Aureus positive for Panton-Valentine leukocidin (PVL). The patients were previously healthy children (2 weeks, 12 years and 15 years old). No epidemiologic connection existed, confirmed by spa-typing. Two cases were primary pneumonias with signs of necrosis, and the third case was a p

Semi-analytical analysis of high-brightness microbunched beam dynamics with collective and intrabeam scattering effects

The studies of incoherent single-particle and collective multi-particle effects are, in general, separated in accelerator beam dynamics in that the two dynamical phenomena involve quite different time scales. Recent experimental measurements indicate that in some parameter regime, the small-angle, multiple scattering effects within a high-brightness electron beam can have a strong influence on mic

Real-Time and Online Segmentation Multi-Target Tracking with Track Revival Re-Identification

The first online segmentation multi-target tracking algorithm with reported real-time speeds is presented. Based on the popular and fast bounding box based tracker SORT, our method called SORTS is able to utilize segmentations for tracking while keeping the real-time speeds. To handle occlusions, which neither SORT nor SORTS do, we also present SORTS+RReID, an optional extension which uses ReID ve

Telomere length in relation to colour polymorphism across life stages in the tawny owl

Telomere erosion has been proposed to be tightly associated with senescence, environmental stressors and life history trade-offs. How telomere dynamics vary across life stages and especially in relation to (heritable) phenotypic traits is still unclear. The tawny owl Strix aluco display a highly heritable melanin-based colour polymorphism, a grey and a brown morph, linked to several fitness traits

Risk Factors for Contra-Lateral Secondary Anterior Cruciate Ligament Injury : A Systematic Review with Meta-Analysis

Background: The risk of sustaining a contra-lateral anterior cruciate ligament (C-ACL) injury after primary unilateral ACL injury is high. C-ACL injury often contributes to a further decline in function and quality of life, including failure to return to sport. There is, however, very limited knowledge about which risk factors that contribute to C-ACL injury. Objective: To systematically review in

Understanding conditions for path development after path exhaustion

This paper focuses on path development processes after a sudden path exhaustion. We analyse the decline, the closure and the attempts at the re-orientation of a forestry-based industry agglomeration in Southern Norway, located around the municipality of Hønefoss. In particular, this paper focuses on the Treklyngen holding company in Hønefoss. This paper explores how policy may be influenced by and

Identifying New Antimigraine Targets : Lessons from Molecular Biology

Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migrai

Party-system polarisation, legislative institutions and cabinet survival in 28 parliamentary democracies, 1945–2019

The resurgence of radical and populist parties has stimulated renewed discussions about the resilience of parliamentary democracy in Europe. This work contributes to this debate by analysing the extent to which positive parliamentarism, the prime minister’s parliamentary dissolution powers, the government’s power to table votes of confidence and the majority requirements for votes of no confidence

Rational Design of Bright Long Fluorescence Lifetime Dyad Fluorophores for Single Molecule Imaging and Detection

Increasing demand for detecting single molecules in challenging environments has raised the bar for the fluorophores used. To achieve better resolution and/or contrast in fluorescence microscopy, it is now essential to use bright and stable dyes with tailored photophysical properties. While long fluorescence lifetime fluorophores offer many advantages in time-resolved imaging, their inherently low

Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma

Gliomas are the most common intracranial primary tumors, for which very few therapeutic options are available. The most malignant subtype is the glioblastoma, a disease associated with a 5-year survival rate lower than 5%. Given that research in glycobiology continues highlighting the role of glycans in tumor cell biology, it offers an interesting niche for the search of new therapeutic targets. I

The Mastigamoeba balamuthi genome and the nature of the free-living ancestor of Entamoeba

The transition of free-living organisms to parasitic organisms is a mysterious process that occurs in all major eukaryotic lineages. Parasites display seemingly unique features associated with their pathogenicity; however, it is important to distinguish ancestral preconditions to parasitism from truly new parasite-specific functions. Here, we sequenced the genome and transcriptome of anaerobic fre

The point vortex model for the Euler equation

In this article we describe the system of point vortices, derived by Helmholtz from the Euler equation, and their associated Gibbs measures. We discuss solution concepts and available results for systems of point vortices with deterministic and random circulations, and further generalizations of the point vortex model.

A semidiscrete scheme for a one-dimensional Cahn-Hilliard equation

We analyze a semidiscrete scheme for the Cahn-Hilliard equation in one space dimension, when the interface length parameter is equal to zero. We prove convergence of the scheme for a suitable class of initial data, and we identify the limit equation. We also characterize the long-time behavior of the limit solutions.