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Visual assessment of medial temporal lobe atrophy (MTA) in the clinical workup of cognitive impairment is traditionally corrected for age since MTA increases with age. In addition, common pathologies in the elderly such as amyloid, tau, alpha-synuclein and TDP-43 accumulation as well as white matter hyperintensities representing small vessel disease may affect the association between MTA and age.
Introduction: Most centers treating patients with anorectal malformation (ARM) will screen for anomalies of the kidneys and urinary tract by using ultrasonography. There is no consensus on whether screening for vesico-ureteral reflux (VUR) should occur. To meet the diagnostic needs of ARM patients a method was developed to include a simultaneous VUR diagnosis and pre-reconstructive fistula work-up
The transformation of CO2 and green hydrogen into methanol presents a sustainable route for chemical and fuel production. Conventional methanol synthesis catalysts, such as Cu/ZnO/Al2O3, employ Al2O3 as a structural promoter, while Ga2O3 has recently emerged as a promising alternative. This study compares Cu-based catalysts supported on Al2O3 (CA) and Ga2O3 (CG), prepared via coprecipitation of la
Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteome) of HSCs in a mouse model carrying a loss-of-function mutation in Tet2, a driver of increased self-renewal in blood cancers. Using state-of-the-art, multiplex
We investigate the influence of AlN buffer thickness on the structural, electrical, and thermal properties of AlGaN/GaN high-electron mobility transistors (HEMTs) grown on semi-insulating SiC substrates by metal-organic chemical vapor deposition. X-ray diffraction and atomic force microscopy reveal that while thin AlN layers (120 nm) exhibit compressive strain and smooth step-flow surfaces, thicke
PURPOSE: The incidence of colorectal cancer (CRC) is increasing in individuals aged < 50 years of age. This study aimed to examine whether high-frequency follow-up after CRC surgery reduces 5-year overall mortality, cancer-specific mortality and recurrence in patients with CRC aged ≤ 50 years. METHODS: The COLOFOL trial performed between 2006 and 2010 was used to analyse patients randomised to hig
Action-detected two-dimensional electronic spectroscopy (A-2DES) provides valuable insights into ultrafast dynamics within functional materials and devices by measuring incoherent signals like photocurrent. This work details the implementation and optimization of a pulse-shaper-based A-2DES setup, focusing on methodological strategies crucial for acquiring high-fidelity data. We present a comprehe
The development of acid-stable, non-precious catalysts for the oxygen evolution reaction (OER) remains a critical challenge for proton exchange membrane water electrolyzers (PEMWEs). While Co3O4 shows promising OER activity, its rapid dissolution in acidic media severely limits practical application. Here, we design a self-adaptive protection strategy by depositing ZrN coatings on Co3O4 precursor
Protein tyrosine phosphatases (PTPs) are a family of enzymes that play important roles in regulating cellular signaling pathways. The activity of these enzymes is regulated by the motion of a catalytic loop that places a critical conserved aspartic acid side chain into the active site for acid–base catalysis upon loop closure. These enzymes also have a conserved phosphate-binding loop that is typi
Atomic layer deposition (ALD) of HfOx layers has emerged as a promising strategy for interface passivation in chalcopyrite-based thin-film solar cells. However, the nucleation dynamics of (Ag,Cu)(In,Ga)Se2 (ACIGS) absorbers remain insufficiently understood, particularly regarding the interplay between absorber composition and alkali postdeposition treatments (PDTs). Here, we employ in situ ambient
The need for information about climate change is great. This information is usually based on climate model data, which often have systematic biases. Furthermore, climate information is based on ensembles of climate models, which raises the question about how such ensembles are affected by the choice of models and emission scenarios. Here, we aim to describe climate change in Sweden and neighbourin
Short-duration extreme rainfall can cause severe impacts in built environments and flood mitigation measures require high-resolution rainfall data to be effective. It is a particular challenge to observe convective storms, which are expected to intensify with climate change. However, rainfall monitoring networks operated by national meteorological and hydrological services generally have limited a
Direct reprogramming of immune cells holds promise for immunotherapy but is constrained by limited knowledge of transcription factor (TF) networks. Here, we developed REPROcode, a combinatorial single-cell screening platform to identify TF combinations for immune cell reprogramming. We first validated REPROcode by inducing type-1 conventional dendritic cells (cDC1s) with multiplexed sets of 9, 22,
Birds can show patterns of sexual size dimorphism as early as the nestling stage. This raises the question of how the faster growing sex might reconcile the energetic and nutritional needs of a faster growth rate with resource allocation to other important life functions, such as the development of innate immune function. Innate immunity represents the main line of defence against diseases, and wh
Global warming accelerates the breakdown of carbon stored in permafrost regions, releasing it into the atmosphere and amplifying climate change, particularly during winter when photosynthesis ceases. The Northern Hemisphere's permafrost is primarily concentrated in two key regions — the Arctic and the Tibetan Plateau — each with distinct environmental characteristics. However, previous studies oft
Memory functions are susceptible to age-related cognitive decline, making it essential to explore the underlying neurophysiological mechanisms that contribute to memory function during healthy ageing. Resting-state EEG (rsEEG) parameters, particularly the aperiodic exponent, a marker of cortical excitation-inhibition balance, and individual alpha peak frequency, a correlate of neural processing ef
