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Aspects of immunopathology in humans during ssRNA virus infections - what do we know and do we have a foundation for treatment? - A narrative review - Part One.

AbstractBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensively and at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential roles in respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the centBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensivelyand at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential rolesin respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the central nervou

Aspects of immunopathology in humans during ssRNA virus infections - what do we know and do we have a foundation for treatment? - A narrative review - Part two.

AbstractBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensively and at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential roles in respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the centBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensivelyand at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential rolesin respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the central nervou

Jewish Children’s Experiences during the Holocaust

This chapter examines the experiences of children in the Holocaust in various geographic contexts. It raises questions about the avenues for rescue and survival of children and the limits of children’s agency. How did gender, age, and family background play a role? And how did children adjust to or resist their new - and supposedly temporary - separation from their families?.

A System Model for the Effect of Self-Balancing in Multiactive Bridge Converters

This article analyzes the effects of self-balancing in multiactive bridge converters. Therefore, it proposes a time-domain approach to model the dynamics of multiwinding transformer-based multilevel dc/dc converter, including self-balancing. In previous research, multiwinding transformers have been modeled using average-based power transfer models. These models, while simple, have no direct intuit

Epidermal Growth Factor Receptor in COPD and Lung Cancer : Is Inflammation the Culprit?

Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are recognized as severe diseases of the lungs and are closely linked to cigarette smoking and environmental pollution and share common mechanisms such as oxidative stress, inflammation, matrix degradation, and airway remodeling. Epidermal growth factor receptor (EGFR), a transmembrane receptor featuring an extracellular ligand bind

Blood Levels of Dendritic Cell Populations in Patients with Moderate to Severe Traumatic Brain Injury

Traumatic brain injury (TBI) leads to intracerebral inflammation involving resident microglial cells and astrocytes as well as invading peripheral dendritic cells (DCs), monocytes, and neutrophils. However, the profile of immune blood cells activated by TBI remains poorly defined. Several animal models showing invasion of circulating classical dendritic cells type 2 (cDC2s) to the traumatically in

Blood culture diagnostics - a comparative and experimental study on the impact of delayed incubation

ObjectivesThis study investigates the impact of transitioning from restricted to 24/7 access to blood culture cabinets on blood culture processing.MethodA post-hoc retrospective study and a prospective laboratory simulation to evaluate the effects of delayed incubation were conducted. Data analysis evaluated clinical data comparing incubation-to-detection (ITD) and Collection-to-detection (CTD) in

Rapport 2021:4 Forskningsundersökning av skeppsvrak vid Stora Ekön, RAÄ Ronneby 728 : Kompletterande undersökning, 2020

Med tillstand fran Lansstyrelsen i Blekinge Ian genomforde Lunds universitet(LU) och Blekinge museum (ELM) den 17-18 november 2020marinarkeologiska undersokningar pa vraket efter den danske kungen Hanskravel Gribshunden. Vrakplatsen ar belagen omedelbart norr om Stora Ekon iRonneby kommun.Syftet med dykningarna 17-18 november 2020 var att barga tramaterial frantunnor for kompletterande dendrokronoDuring 17-18 November 2020, under a permit from Lansstyrel,en in Blekinge issued toBlekinge Museum (BM), a team coordinated by Lund University (LU) conductedmaritime archaeologicalinvestigations ofthe shipwreck known as Gribshunden. The site is located closeto Stora Ekon, near Saxemara. The dive team visually inspected the wreck site, recovered samples of wooden barrels far dendrochronological ana

Solvent-free synthesis of cyclic carbonates

Disclosed is a process for production of a cycloaliphatic carbonate from a diol, triol or polyol and a carbon dioxide source, such as a dialkyl carbonate. Said process is performed in a solvent-free medium using a N-heterocyclic carbene or N-heterocyclic carbene complex as catalyst. Said N-heterocyclic carbene or carbene complex is preferably attached to a lipase. Said process comprises preferably

Functional characterisation of traditional Andean freeze-sun dried potato derivatives, Chuño and Tunta: Resistant starch, probiotic fermentation, and production of SCFA and GABA as bioactive metabolites

Chuño (black) and tunta (white) are two ancient potato derivatives traditionally produced in the high-altitude Andean region through a natural freezing, pressing, washing, and sun-drying process that preserves the tubers for long-term storage. The present study investigates the resistant starch (RS) content, antioxidant capacity, and bioactive metabolites produced by fermentation with probiotic ba

Supply and exhaust ventilation with heat and moisture recovery : Energy use for different solutions and scenarios

Theory and experience exist for much of the components of a combined system with heat recovery ventilation, building and occupant, but the parts are not put together in a comprehensive and analytical way to let the building sector take part of developed and positivistic knowledge that is needed to make predictable and desired dwellings. This project will, together with numerous ongoing projects, a

Anterior Cord Herniation-Surgical Video

Anterior cord herniation is due to a ventral displacement of the spinal cord through a defect in the dura and/or arachnoid.1 Though the condition is rare, some case reports are available.1-3 The neurological symptoms can slowly deteriorate over several years.3 A Brown-Séquard-like syndrome is the most common presenting neurological finding.2,4 Asymptomatic cases may be discovered incidentally.4 Ho

A core outcome set for cranioplasty following stroke or traumatic brain injury - The COAST study

INTRODUCTION: There is substantial heterogeneity in the reporting of outcomes in the global cranioplasty literature. This study aimed to establish a core outcome set (COS) for cranioplasty after decompressive craniectomy for stroke or traumatic brain injury.METHODOLOGY: The scope was defined according to the criteria recommended by the Core Outcome Measures in Effectiveness Trials (COMET) Initiati

A Comparison of Language Processing Models in Political Analysis : Evidence from Sweden

This study evaluates two different natural language processing tech-niques: the normalised co-occurrence (PMI) versus neural networks. Incontrast to most previous studies, the focus is on the context of a propor-tional representation system – Sweden –, where the parties in parliamenttend to form coalitions. We test the models by collecting data from thenational parliament (Swedish Riksdag) and usi

Enhancing healthcare solutions with machine learning-driven adaptive haptic systems

Adaptive haptics, an amalgamation of different haptic systems and machine learning algorithms, has the potential for intelligent feedback in healthcare. Such systems are capable of learning to suit individual user needs in real-time, thereby improving patient care, medical education, and treatment. Targeted techniques of machine learning approaches are reinforcement learning, neural networks, supp

Probabilistic parameter estimation and uncertainty quantification of mode I fracture in wood

The characterisation of wood’s fracture behaviour is a challenging task due to its inherently complex microstructure and natural variability. Consequently, to accurately model wood for engineering applications, deterministic input parameters are rarely sufficient in, for example, finite element models; the stochastic nature of the material must be considered. In the present work, we aim to quantif

Performance of a Zeolite-Filled Slow Filter for Dye Removal and Turbidity Reduction

Ever-increasing global water shortages necessitate more advanced and cost-effective water purification methods. Herein, a novel slow filtration system using natural raw zeolite is proposed as an alternative to traditional quartz sand as a filter medium. The system demonstrates excellent performance in reducing turbidity and removing methylene blue (MB). The natural zeolite-based filtration system

Consensus on the management of traumatic brain injury in older adults : Results from a Delphi study

INTRODUCTION: As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.RESEARCH QUESTION: To reach a consensus among exp

No evidence for a link between mental health symptoms and pain thresholds

Background and Objectives: Previous studies have suggested associations between pain perception and psychological factors such as mood, distress, fatigue, and quality of life. However, these factors and their relationship to pain sensitivity have typically been investigated in isolation and with insufficient sample sizes. To address these limitations, we examine the interplay between distinct psyc