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Background: The development of axonal pathology is a key characteristic of many neurodegenerative disease such as Parkinson's disease and Alzheimer's disease. With advanced disease progression, affected axons do display several signs of pathology such as swelling and fragmentation. In the AAV vector-mediated alpha-synuclein overexpression model of Parkinson's disease, large (> 20 µm2) pathological

BACKGROUND: Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopathogenic role in various neurological diseases. We investigated S100A8/A9 in relation to NP-involvement and fatigue in SLE.METHODS: 72 consecutive SLE outpatients at a tertiary cen

Background and objectivesDarkness is a significant barrier to children’s independent mobility (Shaw et al., 2015) affecting the perception and use of outdoor environments, making them less attractive, and increasing social fears (Cele, 2019). This literature review addresses the question of how artificial outdoor lighting may serve to provide children independent mobility after dark.Process and meBackground and objectivesDarkness is a significant barrier to children’s independent mobility (Shaw et al., 2015) affecting the perception and use of outdoor environments, making them less attractive, and increasing social fears (Cele, 2019). This literature review addresses the question of how artificial outdoor lighting may serve to provide children independent mobilityafter dark.Process and met

The formation of sustainable entrepreneurial ecosystems to foster sustainable entrepreneurship in regional and national levels has become an increasing phenomenon. Therefore, the research stream of sustainable entrepreneurial ecosystems is gaining relevance in the sustainable entrepreneurship literature. What has been missing, however, is an empirical analysis of stakeholder collaborations in sust

This important Research Handbook explores the nexus between human rights, poverty and inequality as a critical lens for understanding and addressing key challenges of the coming decades, including the objectives set out in the Sustainable Development Goals. The Research Handbook starts from the premise that poverty is not solely an issue of minimum income and explores the profound ways that depriv

In this study, a new method was developed to successfully design sustainable microfibers from wheat gluten proteins using a nonreducing solvent and electrospinning. We explored the morphology by X-ray tomography, scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM), protein chemistry and cross-linking by size exclusion-high-performance liquid chromatography (SE-HPLC),