SUMMARYVaccines work primarily by eliciting antibodies, even when recovery from natural infection depends on cellular immunity. Large efforts have therefore been made to identify microbial antigens that elicit protective antibodies, but these endeavors have encountered major difficulties, as witnessed by the lack of vaccines against many pathogens. This review summarizes accumulating evidence that

Climate change affects organisms worldwide with profound ecological and evolutionary consequences, often increasing population extinction risk. Climatic factors can increase the strength, variability, or direction of natural selection on phenotypic traits, potentially driving adaptive evolution. Phenotypic plasticity in relation to temperature can allow organisms to maintain fitness in response to

Trade-offs between absorption and scattering cross sections of lossy obstacles confined to an arbitrarily shaped volume are formulated as a multi-objective optimization problem solvable by Lagrangian-dual methods. Solutions to this optimization problem yield a Pareto-optimal set, the shape of which reveals the feasibility of achieving simultaneously extremal absorption and scattering. Two forms of

AIMS: Heart failure (HF) confers potentially negative effects on the brain and autonomic nervous system. The measurement cerebral tissue oxygen saturation (SctO2 ) may aid in understanding such effects. We aimed to investigate if compensated HF affects SctO2 at rest and during orthostatic challenge.METHODS AND RESULTS: Non-invasive haemodynamic monitoring and near-infrared spectroscopy were applie

Growth factors promote plasticity in injured brain and improve impaired functions. For clinical application, efficient approaches for growth factor delivery into the brain are necessary. Poly(ester amide) (PEA)-derived microspheres (MS) could serve as vehicles due to their thermal and mechanical properties, biocompatibility and biodegradability. Vascular endothelial growth factor (VEGF) exerts bot

Recent studies have highlighted that oscillatory and time-dependent shear flows might help increase the flowability of dense suspensions. While most focus has been on cross-flows we here study a simple two-dimensional suspensions where we apply simultaneously oscillatory and stationary shear along the same direction. We first show that the dissipative viscosities in this set-up significantly decre

Background: Gambling disorder is known to be associated with increased risk of suicidal behavior. However, relatively little is known about how the risk of suicide attempts in gambling disorder is influenced by comorbid alcohol or drug use disorders, as well as other psychiatric conditions. Methods: The present study is a nationwide, diagnostic register study assessing the risk of suicide attempts

An international consensus on antineutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosiswith polyangiitis (EGPA) is presented.ANCA, specific formyeloperoxidase (MPO), can be detected in 30-35% of patients with EGPA. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutio

Spatial downscaling is an effective way to obtain precipitation with sufficient spatial details. The performance of downscaling is typically determined by the empirical statistical relationships between precipitation and the used auxiliary variables. In this study, we conducted a comprehensive comparison of five empirical statistical methods for spatial downscaling of GPM IMERG V06B monthly and an

The origin of the population of very massive stars observed within ∼0.4 pc of the supermassive black hole in the Galactic Centre is a mystery. Tidal forces from the black hole would likely inhibit in situ star formation whilst the youth of the massive stars would seem to exclude formation elsewhere followed by transportation (somehow) into the Galactic Centre. Here, we consider a third way to prod

We investigate the evolution of the abundance of fluorine in the Milky Way thick and thin discs by means of detailed chemical evolution models compared with recent observational data. The chemical evolution models adopted here have already been shown to fit the observed abundance patterns of CNO and α-elements as well as the metallicity distribution functions for the Galactic thick and thin disc s

Asteroid material is detected in white dwarfs (WDs) as atmospheric pollution by metals, in the form of gas/dust discs, or in photometric transits. Within the current paradigm, minor bodies need to be scattered, most likely by planets, into highly eccentric orbits where the material gets disrupted by tidal forces and then accreted on to the star. This can occur through a planet-planet scattering pr

The sharing economy is sometimes described as a big city phenomenon. Among the successful examples of sharing economy, cities such as New York, Amsterdam, Seoul, Bergen, Oslo, and Gothenburg are often highlighted. But the majority of the population of Sweden and many other countries do not live in big cities, but in small towns, medium-sized cities or in a rural area. With a smaller and less dense

This paper focuses on the use of pulse functions and point matching method to construct the impedance matrix needed for the characteristic mode analysis of dielectric bodies. Taking the results given by a commercial Method of Moments (MoM) solver as a benchmark, the proposed method is shown to facilitate accurate characteristic eigenvectors and eigenvalues on these structures using low order basis

Gothenburg is a flourishing green city, with nearly 600,000 inhabitants, located on the west coast of Sweden. Gothenburg has a long tradition of a strong civil society and grass roots movement, which is also reflected when it comes to the development of the sharing economy in the city. Many of the sharing initiatives come from civil society organizations, but the local government has also taken an

A new neighbourhood in Malmö is emerging in Sege Park, an area with a rich history and exciting future. The existing parks and buildings provide the conditions for a good living environment. Sustainability, the sharing economy and urban agriculture are some key words for the building actors who are developing some 800 – 1,000 homes in Sege Park together with the municipality. The innovative aspect

The uniqueness of the Stockholm test-bed is based on its close collaboration with a citizen initiative called Hammarby Sjöstad 2.0 around the mission to create a climate-neutral city district by 2027. The founder of Hammarby Sjöstad 2.0 is ElectriCITY, a (civic society NGO and) membership association which operates a number of energy initiatives in the area since 2012, primarily by targeting the n

Aim: To compare vibrotactile sense, 5 years after carpal tunnel release in people with and without diabetes. Methods: Out of 35 people with diabetes and carpal tunnel syndrome, age- and gender-matched with 31 people without diabetes but with idiopathic carpal tunnel syndrome, 27 and 30 people, respectively, participated in this prolonged follow-up. Vibration perception threshold of the index and l

Over the past 50 years Umeå has displayed constant growth, making it the fastest-growing region in northern Sweden. It is therefore crucial that Umeå grows with regards to environmental, social, cultural and economic aspects. Sharing City Umeå, which is a test-bed for the sharing economy, is focusing on innovative solutions for shared mobility, green spaces, resource efficiency, sustainable consum