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Membrane process opportunities and challenges in the bioethanol industry
Increasing oil prices and growing environmental concerns in recent years have driven the development of renewable biofuels. Until now, most of the bioethanol production concepts are based on sugar and starch crops as feedstock, while research on second generation of bioethanol concepts is investigating the use of cellulosic biomass such as straw, wood, etc. as feedstock. The first part of the pape
Membrane Processes for the Production of Bulk Fermentation Products
The ultrafiltration (UF) with diafiltration is the state-of-the-art process in the bulk pharmaceutical industry to separate solutions containing high and low molecular weight solutes. By applying UF with diafiltration, a feed stream can be separated into a concentrate with a high concentration of high molecular weight solutes and a permeate, which is nearly 100% free of high molecular weight solut
Hydrophobic pervaporation for environmental applications : Process optimization and integration
The focus of this paper is on the design of pervaporation units for wastewater treatment taking into account technical, economic, and environmental aspects. Two different sized industrial wastewater streams of water-chloroform, and of water-methyl-isobutylketone (MIBK) are considered. Based on a wastewater stream of 1,500 kg/d, a semi-batch process combining pervaporation with a decanter recycle l
Concepts of industrial-scale diafiltration systems
The use of diafiltration is now the state-of-the-art in the food and beverage, biotech and pharmaceutical industry. In this paper, the advantages and disadvantages of the most common process modes of diafiltration, batch and continuous, are discussed. Further, the new concept of counter-current diafiltration, which leads to a significant reduction of diafiltration liquid consumption, is introduced
Hydrophobic pervaporation of binary and ternary solutions : Evaluation of fluxes, selectivities, and coupling effects
In hydrophobic pervaporation, the evaluation and prediction of coupling effects in multicomponent systems is one of the key requirements to improve its applicability in the biotechnology and food industry. The focus of this study is first on binary aqueous systems with methanol, ethanol, acetone, 1-propanol, 2-propanol 1,3-dioxane, and 1,4-dioxane, and then on ternary aqueous systems with 1-propan
Carragenan concentration with ultrafiltration
The different processes used for producing carrageenan, which is a sulfated polysaccharide consisting of complex mixture of sodium, potassium, magnesium, and calcium, are discussed. The sources of carrageenan are several genera and species of red algae. The traditional production process involves extraction with water and mechanical devices to remove most extraneous products. A new generation of s
Comparable Results With Porous Metal Augments in Combination With Either Cemented or Uncemented Cups in Revision Hip Arthroplasty : An Analysis of One Hundred Forty-Seven Revisions at a Mean of Five Years
Background: Porous metal augments have been used successfully for management of large acetabular defects during revision hip arthroplasty. The purpose of this study was to retrospectively review and compare the clinical and radiographic outcomes of porous metal augments in cemented and uncemented acetabular revisions, all performed at the same institution. Methods: Using our institutional clinical
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Influence of impermeable components on the permeation of aqueous 1-propanol mixtures in hydrophobic pervaporation
Hydrophobic pervaporation is rarely considered in the biotech industry despite several potential advantages and some applications. This is related to fact that the majority of studies have been with binary feed systems, while real feed mixtures are often multi-component and might contain impermeable components, such as salts and sugars. In order to successfully optimise hydrophobic pervaporation,
Industrial applications of ultrafiltration in pharmaceutical biotechnology
Ultrafiltration with diafiltration is a state-of-the-art process used to separate solutions containing high and low molecular weight solutes. The focus of this paper is on the different concepts of ultrafiltration with diafiltration - batch, continuous and counter-current - and the potential realization of diafiltration on an industrial scale in pharmaceutical biotechnology. Two case studies will
Food & bev : anyone for a tasty beverage?
Taste is the most important criteria in evaluating the quality of wine and beer. Alfa Laval's Frank Lipnizki, Carl-Erik Nielsen, Robert Betcke and Jose Caprio highlight the potential that membrane processes offer in maintaining and improving taste during production.
Membrane applications in the pulp and paper industry : Experience on lab, pilot and industrial scale
Closing the loops in the pulp and paper industry with membrance technology
Membrane technology is a relative new technology in the pulp and paper industry with interesting applications in the water loop, the by-product loop and the chemical loop. The technology was pioneered in the pulp and paper industry by DDS Filtration, now Alfa Laval Nakskov in the 1970'ies and this article reviews the opportunities to use membrane technology in the different loops investigated over
Non-traditional roles of complement in type 2 diabetes : Metabolism, insulin secretion and homeostasis
Type 2 Diabetes (T2D) is a disease of increasing importance and represents a growing burden on global healthcare and human health. In T2D, loss of effectiveness of insulin signaling in peripheral tissues cannot be compensated for by adequate insulin secretion, leading to hyperglycemia and resultant complications. In recent years, inflammation has been identified as a central component of T2D, both
Opportunities and challenges of using ultrafiltration for the concentration of diluted coating materials
The use of cross-flow ultrafiltration for the recovery of coating material from aqueous streams started about 30 years ago with electro-deposition paint in the automotive industry. This early success can be related to both environmental and economical advantages of using ultrafiltration. Ultrafiltration recovers and concentrates electro-deposition paint on the retentate side and produces purified
Method and plant for purifying a carbohydrate rich liquid
Described is a method for preparing a purified liquid containing carbohydrates. The method comprises the steps of: hydrolysing starch to a dextrose equivalent (DE) of 10 or above, thus obtaining a liquid of carbohydrates; removing a heavy weight sludge fraction from the light weight liquid of carbohydrates using centrifugation; filtering the remaining liquid of carbohydrates, the filter being capa
Large eddy simulation of hydrogen combustion in supersonic flows using an Eulerian stochastic fields method
An Eulerian Monte-Carlo approach, the so-called Eulerian stochastic fields (ESF) method is implemented and evaluated for simulation of non-premixed hydrogen/air combustion in supersonic flows. The ESF method is integrated into a compressible flow large eddy simulation (LES) solver, and validated on a supersonic combustor with a strut as flame-holder. Comparison with experimental data and with resu
Differences in glycemic control across world regions : A post-hoc analysis in patients with type 2 diabetes mellitus on dual antidiabetes drug therapy
Objective:This post-hoc analysis of the EDGE (Effectiveness of Diabetes control with vildaGliptin and vildagliptin/mEtformin) study assessed inter-regional differences in baseline characteristics and response to treatment intensification with dual oral antidiabetes drugs (OADs) in patients with type 2 diabetes mellitus (T2DM).Methods:Patients with T2DM inadequately controlled with first-line monot
Accurate prediction tools in prostate cancer require consistent assessment of included variables
Objective: The aim of this study was to create a preoperative prediction model predicting extraprostatic tumour growth in men with clinically organ-confined disease from a prospectively collected Swedish cohort. Materials and methods: The study used data from 3386 men in the prospective multi-centre Laparoscopic Prostatectomy Robot Open (LAPPRO) trial, with 14 participating urological departments.